Therapeutic role of flavonoids and flavones in cancer prevention: Current trends and future perspectives
Cancer is one of notorious diseases across the globe.Therapeutic approaches for cancer are often expensive and develop severe side effects, and usually result comorbidities among the cancer survivors. Identifying novel therapies for treatment will reduce comorbidities in curing these diseases. It ha...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | European Journal of Medicinal Chemistry Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772417421000108 |
| _version_ | 1818852321429291008 |
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| author | Azhar U. Khan Hanuman S. Dagur Masudulla Khan Nazia Malik Mahboob Alam Md Mushtaque |
| author_facet | Azhar U. Khan Hanuman S. Dagur Masudulla Khan Nazia Malik Mahboob Alam Md Mushtaque |
| author_sort | Azhar U. Khan |
| collection | DOAJ |
| description | Cancer is one of notorious diseases across the globe.Therapeutic approaches for cancer are often expensive and develop severe side effects, and usually result comorbidities among the cancer survivors. Identifying novel therapies for treatment will reduce comorbidities in curing these diseases. It has been reported that flavones, a sub-class of flavonoid can act as a potent anticancer agent. Many experimental results displayed that flavones modulate signal transduction pathways in carcinogenesis. Flavones have been found to control cell cycle progression, oxidative stress, angiogenesis and metastasis alongwith some molecular pathways that ultimately prevent the progression of the diseases. Flavones have shown to possess a considerable as cancer preventive agents. As per the reports, flavones rich diet is beneficial, decreased risk of breast cancer, skin, digestive system, certain hematological malignancies and prostate cancer. Apart from cancer, flavones are also effective in improving other disease conditions such as cardiovascular and neurological diseases. Hence, these are the prime target in natural product and drug discovery research. Based on existing findings, it can concluded that more extensive research is needed to understand detailed beneficial properties of flavones along with biochemical mechanisms that drive these medicinal properties. |
| first_indexed | 2024-12-19T07:19:04Z |
| format | Article |
| id | doaj.art-2d58fa02d5664160a49f6bcb46329cad |
| institution | Directory Open Access Journal |
| issn | 2772-4174 |
| language | English |
| last_indexed | 2024-12-19T07:19:04Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Medicinal Chemistry Reports |
| spelling | doaj.art-2d58fa02d5664160a49f6bcb46329cad2022-12-21T20:30:59ZengElsevierEuropean Journal of Medicinal Chemistry Reports2772-41742021-12-013100010Therapeutic role of flavonoids and flavones in cancer prevention: Current trends and future perspectivesAzhar U. Khan0Hanuman S. Dagur1Masudulla Khan2Nazia Malik3Mahboob Alam4Md Mushtaque5School of Life and Basic Sciences, Department of Chemistry, SIILAS Campus Jaipur National University, Jaipur, 302017, Rajasthan, IndiaDepartment of Biotechnology, Indian Institute of Technology, Hyderabad, Telangana, IndiaDepartment of Botany, Aligarh Muslim University, Aligarh, 202002, U.P, IndiaDepartment of Chemistry, Aligarh Muslim University, Aligarh, 202002, U.P, IndiaDivision of Chemistry and Biotechnology, Dongguk University, 123 Dongdae-ro, Gyeongju, 780-714, Republic of KoreaDepartment of Chemistry, School of Physical and Molecular Science, AL-Falah University, Dhauj Faridabad, 121004, Haryana, India; Corresponding author.Cancer is one of notorious diseases across the globe.Therapeutic approaches for cancer are often expensive and develop severe side effects, and usually result comorbidities among the cancer survivors. Identifying novel therapies for treatment will reduce comorbidities in curing these diseases. It has been reported that flavones, a sub-class of flavonoid can act as a potent anticancer agent. Many experimental results displayed that flavones modulate signal transduction pathways in carcinogenesis. Flavones have been found to control cell cycle progression, oxidative stress, angiogenesis and metastasis alongwith some molecular pathways that ultimately prevent the progression of the diseases. Flavones have shown to possess a considerable as cancer preventive agents. As per the reports, flavones rich diet is beneficial, decreased risk of breast cancer, skin, digestive system, certain hematological malignancies and prostate cancer. Apart from cancer, flavones are also effective in improving other disease conditions such as cardiovascular and neurological diseases. Hence, these are the prime target in natural product and drug discovery research. Based on existing findings, it can concluded that more extensive research is needed to understand detailed beneficial properties of flavones along with biochemical mechanisms that drive these medicinal properties.http://www.sciencedirect.com/science/article/pii/S2772417421000108CancerFlavoneFlavonoidsChemopreventionAngiogenesis |
| spellingShingle | Azhar U. Khan Hanuman S. Dagur Masudulla Khan Nazia Malik Mahboob Alam Md Mushtaque Therapeutic role of flavonoids and flavones in cancer prevention: Current trends and future perspectives European Journal of Medicinal Chemistry Reports Cancer Flavone Flavonoids Chemoprevention Angiogenesis |
| title | Therapeutic role of flavonoids and flavones in cancer prevention: Current trends and future perspectives |
| title_full | Therapeutic role of flavonoids and flavones in cancer prevention: Current trends and future perspectives |
| title_fullStr | Therapeutic role of flavonoids and flavones in cancer prevention: Current trends and future perspectives |
| title_full_unstemmed | Therapeutic role of flavonoids and flavones in cancer prevention: Current trends and future perspectives |
| title_short | Therapeutic role of flavonoids and flavones in cancer prevention: Current trends and future perspectives |
| title_sort | therapeutic role of flavonoids and flavones in cancer prevention current trends and future perspectives |
| topic | Cancer Flavone Flavonoids Chemoprevention Angiogenesis |
| url | http://www.sciencedirect.com/science/article/pii/S2772417421000108 |
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