Óxido nítrico: propriedades e potenciais usos terapêuticos Nitric oxide: properties and therapeutic use
<abstract language="eng">Nitric oxide (•NO) is a substance that acts as a second-messenger and is associated with a number of important physiological functions such as regulation of the vascular tonus, immune modulation and neurotransmission. As a physiological mediator, alteration o...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2005-12-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422005000600020 |
| _version_ | 1818177002325147648 |
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| author | Ricardo de L. Barreto Carlos Roque D. Correia Marcelo N. Muscará |
| author_facet | Ricardo de L. Barreto Carlos Roque D. Correia Marcelo N. Muscará |
| author_sort | Ricardo de L. Barreto |
| collection | DOAJ |
| description | <abstract language="eng">Nitric oxide (•NO) is a substance that acts as a second-messenger and is associated with a number of important physiological functions such as regulation of the vascular tonus, immune modulation and neurotransmission. As a physiological mediator, alteration of its concentration level may cause pathophysiological disfunctions such as hypertension, septic shock and impotence. Possible therapeutic approaches are being developed to control NO levels in vivo. We review herein the main physical and chemical properties of •NO, its biological functions and available chemical interventions to reduce and increment its physiological concentration levels. Recent developments in the field are also highlighted. |
| first_indexed | 2024-12-11T20:25:09Z |
| format | Article |
| id | doaj.art-2d5998836b5d4d9daf6f3349dba5a8cd |
| institution | Directory Open Access Journal |
| issn | 0100-4042 1678-7064 |
| language | English |
| last_indexed | 2024-12-11T20:25:09Z |
| publishDate | 2005-12-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-2d5998836b5d4d9daf6f3349dba5a8cd2022-12-22T00:51:58ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-70642005-12-012861046105410.1590/S0100-40422005000600020Óxido nítrico: propriedades e potenciais usos terapêuticos Nitric oxide: properties and therapeutic useRicardo de L. BarretoCarlos Roque D. CorreiaMarcelo N. Muscará<abstract language="eng">Nitric oxide (•NO) is a substance that acts as a second-messenger and is associated with a number of important physiological functions such as regulation of the vascular tonus, immune modulation and neurotransmission. As a physiological mediator, alteration of its concentration level may cause pathophysiological disfunctions such as hypertension, septic shock and impotence. Possible therapeutic approaches are being developed to control NO levels in vivo. We review herein the main physical and chemical properties of •NO, its biological functions and available chemical interventions to reduce and increment its physiological concentration levels. Recent developments in the field are also highlighted.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422005000600020nitric oxideNOS inhibitorsNO-donors |
| spellingShingle | Ricardo de L. Barreto Carlos Roque D. Correia Marcelo N. Muscará Óxido nítrico: propriedades e potenciais usos terapêuticos Nitric oxide: properties and therapeutic use Química Nova nitric oxide NOS inhibitors NO-donors |
| title | Óxido nítrico: propriedades e potenciais usos terapêuticos Nitric oxide: properties and therapeutic use |
| title_full | Óxido nítrico: propriedades e potenciais usos terapêuticos Nitric oxide: properties and therapeutic use |
| title_fullStr | Óxido nítrico: propriedades e potenciais usos terapêuticos Nitric oxide: properties and therapeutic use |
| title_full_unstemmed | Óxido nítrico: propriedades e potenciais usos terapêuticos Nitric oxide: properties and therapeutic use |
| title_short | Óxido nítrico: propriedades e potenciais usos terapêuticos Nitric oxide: properties and therapeutic use |
| title_sort | oxido nitrico propriedades e potenciais usos terapeuticos nitric oxide properties and therapeutic use |
| topic | nitric oxide NOS inhibitors NO-donors |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422005000600020 |
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