Homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of Aspergillus against hypersensitivity responses
Summary: Fungi cause various forms of invasive fungal disease (IFD), and fungal sensitization can contribute to the development of asthma, asthma severity, and other hypersensitivity diseases, such as atopic dermatitis (AD). In this study, we introduce a facile and controllable approach, using homob...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222021952 |
| _version_ | 1797903364645715968 |
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| author | Huifang Liu KeLun Zhang Yoon Ok Jang Zhen Qiao Jie Jin Thuy Nguyen Thi Dao Bonhan Koo Chang Ook Park Yong Shin |
| author_facet | Huifang Liu KeLun Zhang Yoon Ok Jang Zhen Qiao Jie Jin Thuy Nguyen Thi Dao Bonhan Koo Chang Ook Park Yong Shin |
| author_sort | Huifang Liu |
| collection | DOAJ |
| description | Summary: Fungi cause various forms of invasive fungal disease (IFD), and fungal sensitization can contribute to the development of asthma, asthma severity, and other hypersensitivity diseases, such as atopic dermatitis (AD). In this study, we introduce a facile and controllable approach, using homobifunctional imidoester-modified zinc nano-spindle (HINS), for attenuating hyphae growth of fungi and reducing the hypersensitivity response complications in fungi-infected mice. To extend the study of the specificity and immune mechanisms, we used HINS-cultured Aspergillus extract (HI-AsE) and common agar-cultured Aspergillus extract (Con-AsE) as the refined mouse models. HINS composites within the safe concentration range inhibited the hyphae growth of fungi but also reduce the number of fungal pathogens. Through the evaluation of lung and skin tissues from the mice, asthma pathogenesis (lung) and the hypersensitivity response (skin) to invasive aspergillosis were least severe in HI-AsE-infected mice. Therefore, HINS composites attenuate asthma and the hypersensitivity response to invasive aspergillosis. |
| first_indexed | 2024-04-10T09:31:44Z |
| format | Article |
| id | doaj.art-2d5a13c11c294bddb1a3d4b4c07b9a3f |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-10T09:31:44Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-2d5a13c11c294bddb1a3d4b4c07b9a3f2023-02-19T04:26:33ZengElsevieriScience2589-00422023-02-01262105922Homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of Aspergillus against hypersensitivity responsesHuifang Liu0KeLun Zhang1Yoon Ok Jang2Zhen Qiao3Jie Jin4Thuy Nguyen Thi Dao5Bonhan Koo6Chang Ook Park7Yong Shin8Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of KoreaDepartment of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, KoreaDepartment of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of KoreaDepartment of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of KoreaDepartment of Chemical and Biomolecular Engineering, Yonsei University, Seoul 03722, Republic of KoreaDepartment of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of KoreaDepartment of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of KoreaDepartment of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea; Corresponding authorDepartment of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea; Corresponding authorSummary: Fungi cause various forms of invasive fungal disease (IFD), and fungal sensitization can contribute to the development of asthma, asthma severity, and other hypersensitivity diseases, such as atopic dermatitis (AD). In this study, we introduce a facile and controllable approach, using homobifunctional imidoester-modified zinc nano-spindle (HINS), for attenuating hyphae growth of fungi and reducing the hypersensitivity response complications in fungi-infected mice. To extend the study of the specificity and immune mechanisms, we used HINS-cultured Aspergillus extract (HI-AsE) and common agar-cultured Aspergillus extract (Con-AsE) as the refined mouse models. HINS composites within the safe concentration range inhibited the hyphae growth of fungi but also reduce the number of fungal pathogens. Through the evaluation of lung and skin tissues from the mice, asthma pathogenesis (lung) and the hypersensitivity response (skin) to invasive aspergillosis were least severe in HI-AsE-infected mice. Therefore, HINS composites attenuate asthma and the hypersensitivity response to invasive aspergillosis.http://www.sciencedirect.com/science/article/pii/S2589004222021952Pathogenic organismTreatmentNanomaterials |
| spellingShingle | Huifang Liu KeLun Zhang Yoon Ok Jang Zhen Qiao Jie Jin Thuy Nguyen Thi Dao Bonhan Koo Chang Ook Park Yong Shin Homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of Aspergillus against hypersensitivity responses iScience Pathogenic organism Treatment Nanomaterials |
| title | Homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of Aspergillus against hypersensitivity responses |
| title_full | Homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of Aspergillus against hypersensitivity responses |
| title_fullStr | Homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of Aspergillus against hypersensitivity responses |
| title_full_unstemmed | Homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of Aspergillus against hypersensitivity responses |
| title_short | Homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of Aspergillus against hypersensitivity responses |
| title_sort | homobifunctional imidoester modified zinc nano spindle attenuated hyphae growth of aspergillus against hypersensitivity responses |
| topic | Pathogenic organism Treatment Nanomaterials |
| url | http://www.sciencedirect.com/science/article/pii/S2589004222021952 |
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