Treatment of invasive fungal infections: stability of voriconazole infusion solutions in PVC bags
Voriconazole is a novel broad-spectrum antifungal drug, employed in the treatment of invasive fungal infections, and represents an alternative to amphotericin B treatment. The manufacturer recommends that any unused reconstituted product should be stored at 2ºC to 8ºC, for no more than 24 h, but no...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
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| Series: | Brazilian Journal of Infectious Diseases |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500011&lng=en&tlng=en |
| _version_ | 1818294883708829696 |
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| author | Andréa I.H. Adams Lucia N. Morimoto Leonardo Z. Meneghini Ana M. Bergold |
| author_facet | Andréa I.H. Adams Lucia N. Morimoto Leonardo Z. Meneghini Ana M. Bergold |
| author_sort | Andréa I.H. Adams |
| collection | DOAJ |
| description | Voriconazole is a novel broad-spectrum antifungal drug, employed in the treatment of invasive fungal infections, and represents an alternative to amphotericin B treatment. The manufacturer recommends that any unused reconstituted product should be stored at 2ºC to 8ºC, for no more than 24 h, but no recommendations about i.v. infusion solutions are given. Previous works have reported on the stability of voriconazole in polyolefin bags and just one in 5% dextrose polyvinyl chloride (PVC) bags, at a 4 mg.mL-1 concentration. In this work, the stability of voriconazole as an i.v. infusion solution in 0.9% sodium chloride and in 5% dextrose, in PVC bags, at 0.5 mg.mL-1, stored at 4 ºC and at room temperature, protected from light, was evaluated. These infusion solutions were analyzed for a 21-day period. Chemical stability was evaluated by HPLC assay. Visual inspection was performed and pH of the solutions was measured. No color change or precipitation in the solutions was observed. The drug content remained above 90% for 11 days in 0.9% sodium chloride and for 9 days in 5% dextrose solutions. The i.v. infusion solutions stored at room temperature were not stable. At room temperature, the voriconazole content dropped down to 88.3 and 86.6%, in 0.9% sodium chloride or 5% dextrose solutions, respectively, two days after admixture. Assays performed at the end of the study suggest the sorption of voriconazole by the PVC bags. The results of this study allow cost-effective batch production in the hospital pharmacy. |
| first_indexed | 2024-12-13T03:38:50Z |
| format | Article |
| id | doaj.art-2d5aca278e7843b29ec2e7d12b1840ec |
| institution | Directory Open Access Journal |
| issn | 1678-4391 |
| language | English |
| last_indexed | 2024-12-13T03:38:50Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-2d5aca278e7843b29ec2e7d12b1840ec2022-12-22T00:00:59ZengElsevierBrazilian Journal of Infectious Diseases1678-439112540040410.1590/S1413-86702008000500011S1413-86702008000500011Treatment of invasive fungal infections: stability of voriconazole infusion solutions in PVC bagsAndréa I.H. Adams0Lucia N. Morimoto1Leonardo Z. Meneghini2Ana M. Bergold3Universidade Federal do Rio Grande do SulUniversidade Federal do Rio Grande do SulUniversidade Federal do Rio Grande do SulUniversidade Federal do Rio Grande do SulVoriconazole is a novel broad-spectrum antifungal drug, employed in the treatment of invasive fungal infections, and represents an alternative to amphotericin B treatment. The manufacturer recommends that any unused reconstituted product should be stored at 2ºC to 8ºC, for no more than 24 h, but no recommendations about i.v. infusion solutions are given. Previous works have reported on the stability of voriconazole in polyolefin bags and just one in 5% dextrose polyvinyl chloride (PVC) bags, at a 4 mg.mL-1 concentration. In this work, the stability of voriconazole as an i.v. infusion solution in 0.9% sodium chloride and in 5% dextrose, in PVC bags, at 0.5 mg.mL-1, stored at 4 ºC and at room temperature, protected from light, was evaluated. These infusion solutions were analyzed for a 21-day period. Chemical stability was evaluated by HPLC assay. Visual inspection was performed and pH of the solutions was measured. No color change or precipitation in the solutions was observed. The drug content remained above 90% for 11 days in 0.9% sodium chloride and for 9 days in 5% dextrose solutions. The i.v. infusion solutions stored at room temperature were not stable. At room temperature, the voriconazole content dropped down to 88.3 and 86.6%, in 0.9% sodium chloride or 5% dextrose solutions, respectively, two days after admixture. Assays performed at the end of the study suggest the sorption of voriconazole by the PVC bags. The results of this study allow cost-effective batch production in the hospital pharmacy.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500011&lng=en&tlng=enAntifungal drugsvoriconazolevoriconazole stabilityvoriconazole infusion solutionsPVC bags |
| spellingShingle | Andréa I.H. Adams Lucia N. Morimoto Leonardo Z. Meneghini Ana M. Bergold Treatment of invasive fungal infections: stability of voriconazole infusion solutions in PVC bags Brazilian Journal of Infectious Diseases Antifungal drugs voriconazole voriconazole stability voriconazole infusion solutions PVC bags |
| title | Treatment of invasive fungal infections: stability of voriconazole infusion solutions in PVC bags |
| title_full | Treatment of invasive fungal infections: stability of voriconazole infusion solutions in PVC bags |
| title_fullStr | Treatment of invasive fungal infections: stability of voriconazole infusion solutions in PVC bags |
| title_full_unstemmed | Treatment of invasive fungal infections: stability of voriconazole infusion solutions in PVC bags |
| title_short | Treatment of invasive fungal infections: stability of voriconazole infusion solutions in PVC bags |
| title_sort | treatment of invasive fungal infections stability of voriconazole infusion solutions in pvc bags |
| topic | Antifungal drugs voriconazole voriconazole stability voriconazole infusion solutions PVC bags |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500011&lng=en&tlng=en |
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