miRNA as a Biomarker for the Early Detection of Colorectal Cancer
MicroRNAs (miRNAs) are short, non-coding RNA segments that can be detected in a variety of clinical samples, including serum, stool, and urine. While miRNAs were initially known for their effect on post-translational gene expression, the last decade of research has shown them to be promising biomark...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Genes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4425/15/3/338 |
| _version_ | 1797240872545288192 |
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| author | David Coleman Scott Kuwada |
| author_facet | David Coleman Scott Kuwada |
| author_sort | David Coleman |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) are short, non-coding RNA segments that can be detected in a variety of clinical samples, including serum, stool, and urine. While miRNAs were initially known for their effect on post-translational gene expression, the last decade of research has shown them to be promising biomarkers for the detection of many types of cancer. This paper explores the use of miRNA detection as a tool for colorectal cancer (CRC) screening. We discuss the current state of miRNA detection, compare it to the existing CRC screening tools, and highlight the advantages and drawbacks of this approach from a clinical and logistical perspective. Our research finds that miRNA-based tests for CRC show great potential, but that widespread clinical adoption will be conditional on future research overcoming key hurdles. |
| first_indexed | 2024-04-24T18:14:20Z |
| format | Article |
| id | doaj.art-2d5b5d37f5f74ad7a751414e826f59e0 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-04-24T18:14:20Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-2d5b5d37f5f74ad7a751414e826f59e02024-03-27T13:43:07ZengMDPI AGGenes2073-44252024-03-0115333810.3390/genes15030338miRNA as a Biomarker for the Early Detection of Colorectal CancerDavid Coleman0Scott Kuwada1John A. Burns School of Medicine, University of Hawaii, 651 Ilalo Street, Honolulu, HI 96813, USAJohn A. Burns School of Medicine, University of Hawaii, 651 Ilalo Street, Honolulu, HI 96813, USAMicroRNAs (miRNAs) are short, non-coding RNA segments that can be detected in a variety of clinical samples, including serum, stool, and urine. While miRNAs were initially known for their effect on post-translational gene expression, the last decade of research has shown them to be promising biomarkers for the detection of many types of cancer. This paper explores the use of miRNA detection as a tool for colorectal cancer (CRC) screening. We discuss the current state of miRNA detection, compare it to the existing CRC screening tools, and highlight the advantages and drawbacks of this approach from a clinical and logistical perspective. Our research finds that miRNA-based tests for CRC show great potential, but that widespread clinical adoption will be conditional on future research overcoming key hurdles.https://www.mdpi.com/2073-4425/15/3/338colorectal cancerCRCmiRNAmicroRNAbiomarkerCRC screening |
| spellingShingle | David Coleman Scott Kuwada miRNA as a Biomarker for the Early Detection of Colorectal Cancer Genes colorectal cancer CRC miRNA microRNA biomarker CRC screening |
| title | miRNA as a Biomarker for the Early Detection of Colorectal Cancer |
| title_full | miRNA as a Biomarker for the Early Detection of Colorectal Cancer |
| title_fullStr | miRNA as a Biomarker for the Early Detection of Colorectal Cancer |
| title_full_unstemmed | miRNA as a Biomarker for the Early Detection of Colorectal Cancer |
| title_short | miRNA as a Biomarker for the Early Detection of Colorectal Cancer |
| title_sort | mirna as a biomarker for the early detection of colorectal cancer |
| topic | colorectal cancer CRC miRNA microRNA biomarker CRC screening |
| url | https://www.mdpi.com/2073-4425/15/3/338 |
| work_keys_str_mv | AT davidcoleman mirnaasabiomarkerfortheearlydetectionofcolorectalcancer AT scottkuwada mirnaasabiomarkerfortheearlydetectionofcolorectalcancer |