The BDNF Val66Met Polymorphism Has No Effect on Encoding-Related Hippocampal Response But Influences Recall in Remitted Patients With Bipolar Disorder
Background: Cognitive impairments in bipolar disorder (BD) such as memory deficits are associated with poor functional outcomes and it has been suggested that the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism contributes to individual variability in memory function in BD. The curren...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-12-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00845/full |
| _version_ | 1818018911536283648 |
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| author | Lone Diana Hørlyck Lone Diana Hørlyck Julian Macoveanu Maj Vinberg Lars Vedel Kessing Hartwig Roman Siebner Hartwig Roman Siebner Kamilla Woznica Miskowiak Kamilla Woznica Miskowiak |
| author_facet | Lone Diana Hørlyck Lone Diana Hørlyck Julian Macoveanu Maj Vinberg Lars Vedel Kessing Hartwig Roman Siebner Hartwig Roman Siebner Kamilla Woznica Miskowiak Kamilla Woznica Miskowiak |
| author_sort | Lone Diana Hørlyck |
| collection | DOAJ |
| description | Background: Cognitive impairments in bipolar disorder (BD) such as memory deficits are associated with poor functional outcomes and it has been suggested that the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism contributes to individual variability in memory function in BD. The current study investigated the relationship between the BDNF Val66Met polymorphism, neural activity during a picture-encoding task, and subsequent memory recall.Methods: A total of 70 patients with BD grouped according to genotype [ValVal or Met carriers (MetVal/MetMet)] underwent fMRI while performing a picture-encoding task. Memory for the encoded pictures was tested with a subsequent free recall memory task.Results: There was no difference between the ValVal homozygotes and Met carriers in the involvement of hypothesized memory encoding regions i.e. hippocampus and dorsal prefrontal cortex (dPFC). However, an exploratory whole-brain analysis showed greater encoding-related lateral occipital cortex activity in Met carriers. Behaviorally, Met carriers also showed better free recall of the encoded pictures.Conclusions: We found no effect of the BDNF genotype on encoding-related hippocampal and dPFC activity in BD, although Met carriers showed superior memory performance after the scan, which could be related to more efficient perceptual processing during encoding. |
| first_indexed | 2024-04-14T07:45:50Z |
| format | Article |
| id | doaj.art-2d5b9fbbe6c3407e8fe5d6b6a7d7097c |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-14T07:45:50Z |
| publishDate | 2019-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-2d5b9fbbe6c3407e8fe5d6b6a7d7097c2022-12-22T02:05:20ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402019-12-011010.3389/fpsyt.2019.00845472784The BDNF Val66Met Polymorphism Has No Effect on Encoding-Related Hippocampal Response But Influences Recall in Remitted Patients With Bipolar DisorderLone Diana Hørlyck0Lone Diana Hørlyck1Julian Macoveanu2Maj Vinberg3Lars Vedel Kessing4Hartwig Roman Siebner5Hartwig Roman Siebner6Kamilla Woznica Miskowiak7Kamilla Woznica Miskowiak8Neurocognition and Emotion in Affective Disorders (NEAD) Group, Copenhagen Affective Disorder Research Centre (CADIC), Copenhagen Psychiatric Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, DenmarkDepartment of Psychology, University of Copenhagen, Copenhagen, DenmarkNeurocognition and Emotion in Affective Disorders (NEAD) Group, Copenhagen Affective Disorder Research Centre (CADIC), Copenhagen Psychiatric Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, DenmarkCADIC, Copenhagen Psychiatric Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, DenmarkCADIC, Copenhagen Psychiatric Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, DenmarkDanish Research Centre for Magnetic Resonance (DRCMR), Centre for Functional and Diagnostic Imaging and Research, Hvidovre Hospital, University of Copenhagen, Copenhagen, DenmarkDepartment of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, DenmarkNeurocognition and Emotion in Affective Disorders (NEAD) Group, Copenhagen Affective Disorder Research Centre (CADIC), Copenhagen Psychiatric Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, DenmarkDepartment of Psychology, University of Copenhagen, Copenhagen, DenmarkBackground: Cognitive impairments in bipolar disorder (BD) such as memory deficits are associated with poor functional outcomes and it has been suggested that the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism contributes to individual variability in memory function in BD. The current study investigated the relationship between the BDNF Val66Met polymorphism, neural activity during a picture-encoding task, and subsequent memory recall.Methods: A total of 70 patients with BD grouped according to genotype [ValVal or Met carriers (MetVal/MetMet)] underwent fMRI while performing a picture-encoding task. Memory for the encoded pictures was tested with a subsequent free recall memory task.Results: There was no difference between the ValVal homozygotes and Met carriers in the involvement of hypothesized memory encoding regions i.e. hippocampus and dorsal prefrontal cortex (dPFC). However, an exploratory whole-brain analysis showed greater encoding-related lateral occipital cortex activity in Met carriers. Behaviorally, Met carriers also showed better free recall of the encoded pictures.Conclusions: We found no effect of the BDNF genotype on encoding-related hippocampal and dPFC activity in BD, although Met carriers showed superior memory performance after the scan, which could be related to more efficient perceptual processing during encoding.https://www.frontiersin.org/article/10.3389/fpsyt.2019.00845/fullhippocampuscognitive impairmentaffective disordersfMRIBDNF val66met genotype |
| spellingShingle | Lone Diana Hørlyck Lone Diana Hørlyck Julian Macoveanu Maj Vinberg Lars Vedel Kessing Hartwig Roman Siebner Hartwig Roman Siebner Kamilla Woznica Miskowiak Kamilla Woznica Miskowiak The BDNF Val66Met Polymorphism Has No Effect on Encoding-Related Hippocampal Response But Influences Recall in Remitted Patients With Bipolar Disorder Frontiers in Psychiatry hippocampus cognitive impairment affective disorders fMRI BDNF val66met genotype |
| title | The BDNF Val66Met Polymorphism Has No Effect on Encoding-Related Hippocampal Response But Influences Recall in Remitted Patients With Bipolar Disorder |
| title_full | The BDNF Val66Met Polymorphism Has No Effect on Encoding-Related Hippocampal Response But Influences Recall in Remitted Patients With Bipolar Disorder |
| title_fullStr | The BDNF Val66Met Polymorphism Has No Effect on Encoding-Related Hippocampal Response But Influences Recall in Remitted Patients With Bipolar Disorder |
| title_full_unstemmed | The BDNF Val66Met Polymorphism Has No Effect on Encoding-Related Hippocampal Response But Influences Recall in Remitted Patients With Bipolar Disorder |
| title_short | The BDNF Val66Met Polymorphism Has No Effect on Encoding-Related Hippocampal Response But Influences Recall in Remitted Patients With Bipolar Disorder |
| title_sort | bdnf val66met polymorphism has no effect on encoding related hippocampal response but influences recall in remitted patients with bipolar disorder |
| topic | hippocampus cognitive impairment affective disorders fMRI BDNF val66met genotype |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00845/full |
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