Antiplatelet aggregation of garlic (Alliun sativum L.) water extract, turmeric (Curcuma domestica Val.) ethanolic extract and its combination to Swiss Webster male mice
Antiplatelet aggregation effect of garlic (Allium sativum L.) water extract, turmeric (Curcuma domestica Val.) ethanolic extract and its combination to Swiss Webster mice has been investigated. The test substances given orally during the period of 28 days. Antiplatelet aggregation effect was tested...
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| Format: | Article |
| Language: | English |
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Universitas Gadjah Mada
2008-01-01
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| Series: | Indonesian Journal of Pharmacy |
| Subjects: | |
| Online Access: | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/289 |
| _version_ | 1818501400116592640 |
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| author | Elin Yulinah Iskandar Joseph I Sigit Nurul Fitriyani |
| author_facet | Elin Yulinah Iskandar Joseph I Sigit Nurul Fitriyani |
| author_sort | Elin Yulinah Iskandar |
| collection | DOAJ |
| description | Antiplatelet aggregation effect of garlic (Allium sativum L.) water extract, turmeric (Curcuma domestica Val.) ethanolic extract and its combination to Swiss Webster mice has been investigated. The test substances given orally during the period of 28 days. Antiplatelet aggregation effect was tested by measuring bleeding time, coagulation time, and
decreasing plasma absorbance to observe platelet aggregation activity before and after addition of ADP as platelet aggregation inducer. Based on the inhibition of plasma abdorbance decrease, turmeric extract at a dose of 100 mg/kg body weight, garlic extract at a dose of 100 mg/kg body weight, combination of turmeric at a dose of 100 mg/kg body weight and garlic extract at a dose of 100 mg/kg body weight as well as combination of turmeric at a dose of 50 mg/kg body weight and garlic extract at a dose of 50 mg/kg body weight showed the effect of platelet aggregation inhibition of 73.67 ± 10.30% (p=0.021); 74.67 ± 25.04% (p=0.018); 77.43 ± 8.09% (p=0.018); and 57.00 ± 23.87% (p=0.047) respectively. The test substances above respectively increased bleeding time of 473.08 ± 56.12% (p<0.000); 427.53 ± 66.89% (p<0.000); 515.73 ± 114.47% (p= 0.001); 481.73 ± 116.51% (p=0.001). Increasing coagulation time only showed by combination of turmeric and garlic extract at a dose of each 100 mg/kg body weight and also of each 50 mg/kg body weight with percentage of 46.67 ± 21.89% (p=0.014) and 40.84 ± 25.80% (p=0.018). |
| first_indexed | 2024-12-10T20:55:39Z |
| format | Article |
| id | doaj.art-2d5c1ce3e5cd4a97a68667b073b395af |
| institution | Directory Open Access Journal |
| issn | 2338-9427 2338-9486 |
| language | English |
| last_indexed | 2024-12-10T20:55:39Z |
| publishDate | 2008-01-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Pharmacy |
| spelling | doaj.art-2d5c1ce3e5cd4a97a68667b073b395af2022-12-22T01:33:57ZengUniversitas Gadjah MadaIndonesian Journal of Pharmacy2338-94272338-94862008-01-01191111http://dx.doi.org/10.14499/indonesianjpharm0iss0pp1-11Antiplatelet aggregation of garlic (Alliun sativum L.) water extract, turmeric (Curcuma domestica Val.) ethanolic extract and its combination to Swiss Webster male miceElin Yulinah Iskandar0Joseph I Sigit1Nurul Fitriyani2http://dx.doi.org/10.14499/indonesianjpharm0iss0pp1-11http://dx.doi.org/10.14499/indonesianjpharm0iss0pp1-11http://dx.doi.org/10.14499/indonesianjpharm0iss0pp1-11Antiplatelet aggregation effect of garlic (Allium sativum L.) water extract, turmeric (Curcuma domestica Val.) ethanolic extract and its combination to Swiss Webster mice has been investigated. The test substances given orally during the period of 28 days. Antiplatelet aggregation effect was tested by measuring bleeding time, coagulation time, and decreasing plasma absorbance to observe platelet aggregation activity before and after addition of ADP as platelet aggregation inducer. Based on the inhibition of plasma abdorbance decrease, turmeric extract at a dose of 100 mg/kg body weight, garlic extract at a dose of 100 mg/kg body weight, combination of turmeric at a dose of 100 mg/kg body weight and garlic extract at a dose of 100 mg/kg body weight as well as combination of turmeric at a dose of 50 mg/kg body weight and garlic extract at a dose of 50 mg/kg body weight showed the effect of platelet aggregation inhibition of 73.67 ± 10.30% (p=0.021); 74.67 ± 25.04% (p=0.018); 77.43 ± 8.09% (p=0.018); and 57.00 ± 23.87% (p=0.047) respectively. The test substances above respectively increased bleeding time of 473.08 ± 56.12% (p<0.000); 427.53 ± 66.89% (p<0.000); 515.73 ± 114.47% (p= 0.001); 481.73 ± 116.51% (p=0.001). Increasing coagulation time only showed by combination of turmeric and garlic extract at a dose of each 100 mg/kg body weight and also of each 50 mg/kg body weight with percentage of 46.67 ± 21.89% (p=0.014) and 40.84 ± 25.80% (p=0.018).http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/289Antiplatelet aggregationturmericgarlicADP |
| spellingShingle | Elin Yulinah Iskandar Joseph I Sigit Nurul Fitriyani Antiplatelet aggregation of garlic (Alliun sativum L.) water extract, turmeric (Curcuma domestica Val.) ethanolic extract and its combination to Swiss Webster male mice Indonesian Journal of Pharmacy Antiplatelet aggregation turmeric garlic ADP |
| title | Antiplatelet aggregation of garlic (Alliun sativum L.) water extract, turmeric (Curcuma domestica Val.) ethanolic extract and its combination to Swiss Webster male mice |
| title_full | Antiplatelet aggregation of garlic (Alliun sativum L.) water extract, turmeric (Curcuma domestica Val.) ethanolic extract and its combination to Swiss Webster male mice |
| title_fullStr | Antiplatelet aggregation of garlic (Alliun sativum L.) water extract, turmeric (Curcuma domestica Val.) ethanolic extract and its combination to Swiss Webster male mice |
| title_full_unstemmed | Antiplatelet aggregation of garlic (Alliun sativum L.) water extract, turmeric (Curcuma domestica Val.) ethanolic extract and its combination to Swiss Webster male mice |
| title_short | Antiplatelet aggregation of garlic (Alliun sativum L.) water extract, turmeric (Curcuma domestica Val.) ethanolic extract and its combination to Swiss Webster male mice |
| title_sort | antiplatelet aggregation of garlic alliun sativum l water extract turmeric curcuma domestica val ethanolic extract and its combination to swiss webster male mice |
| topic | Antiplatelet aggregation turmeric garlic ADP |
| url | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/289 |
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