Biogenesis, function, and landscape of tsRNAs in central nervous system diseases
Abstract Transfer RNA‐derived small RNAs (tsRNAs) are fragments that originate from mature or precursor tRNAs and are a subclass of sRNAs. With the development of high‐throughput sequencing techniques, the real feature of tsRNAs has gradually been revealed. tsRNAs are functional fragments of distinc...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-08-01
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| Series: | Clinical and Translational Discovery |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ctd2.221 |
| _version_ | 1797736126041030656 |
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| author | Kaiying Yang Yu Sun Jie Zhao Chang He Xudong Pan Xiaoyan Zhu |
| author_facet | Kaiying Yang Yu Sun Jie Zhao Chang He Xudong Pan Xiaoyan Zhu |
| author_sort | Kaiying Yang |
| collection | DOAJ |
| description | Abstract Transfer RNA‐derived small RNAs (tsRNAs) are fragments that originate from mature or precursor tRNAs and are a subclass of sRNAs. With the development of high‐throughput sequencing techniques, the real feature of tsRNAs has gradually been revealed. tsRNAs are functional fragments of distinct lengths produced by the cleavage of mature or precursor tRNAs by different ribonuclease enzymes. tsRNAs exert extensive functions, including gene silencing, translational regulation, and reverse transcriptional regulation, affecting cell viability and differentiation and participating in pathological processes of various diseases, including central nervous system (CNS) diseases. Emerging sequencing evidence indicates that tsRNAs are expressed differently in various CNS diseases, preliminary suggesting that tsRNAs are involved in the occurrence and progression of neurodegenerative diseases, stroke, glioma, epilepsy, and other CNS diseases. In addition, significant differences expression of extracellular tsRNAs in circulating or cerebrospinal fluid between patients and normal individuals have demonstrated the diagnostic and prognostic value of tsRNAs as biomarkers for liquid biopsy. In this review, we provide a detailed summary of the biogenesis, function, and chemical modification of tsRNAs, focusing on the current status and prospects of research on tsRNAs in neurodegenerative diseases, stroke, glioma, epilepsy, and others. |
| first_indexed | 2024-03-12T13:09:04Z |
| format | Article |
| id | doaj.art-2d5cb517d37f4261b6f3b1a84ff9f87e |
| institution | Directory Open Access Journal |
| issn | 2768-0622 |
| language | English |
| last_indexed | 2024-03-12T13:09:04Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Discovery |
| spelling | doaj.art-2d5cb517d37f4261b6f3b1a84ff9f87e2023-08-28T06:44:32ZengWileyClinical and Translational Discovery2768-06222023-08-0134n/an/a10.1002/ctd2.221Biogenesis, function, and landscape of tsRNAs in central nervous system diseasesKaiying Yang0Yu Sun1Jie Zhao2Chang He3Xudong Pan4Xiaoyan Zhu5Department of Neurology The Affiliated Hospital of Qingdao University QingdaoChinaDepartment of Neurology The Affiliated Hospital of Qingdao University QingdaoChinaDepartment of Neurology The Affiliated Hospital of Qingdao University QingdaoChinaDepartment of Critical Care Medicine The Affiliated Hospital of Qingdao University QingdaoChinaDepartment of Neurology The Affiliated Hospital of Qingdao University QingdaoChinaDepartment of Critical Care Medicine The Affiliated Hospital of Qingdao University QingdaoChinaAbstract Transfer RNA‐derived small RNAs (tsRNAs) are fragments that originate from mature or precursor tRNAs and are a subclass of sRNAs. With the development of high‐throughput sequencing techniques, the real feature of tsRNAs has gradually been revealed. tsRNAs are functional fragments of distinct lengths produced by the cleavage of mature or precursor tRNAs by different ribonuclease enzymes. tsRNAs exert extensive functions, including gene silencing, translational regulation, and reverse transcriptional regulation, affecting cell viability and differentiation and participating in pathological processes of various diseases, including central nervous system (CNS) diseases. Emerging sequencing evidence indicates that tsRNAs are expressed differently in various CNS diseases, preliminary suggesting that tsRNAs are involved in the occurrence and progression of neurodegenerative diseases, stroke, glioma, epilepsy, and other CNS diseases. In addition, significant differences expression of extracellular tsRNAs in circulating or cerebrospinal fluid between patients and normal individuals have demonstrated the diagnostic and prognostic value of tsRNAs as biomarkers for liquid biopsy. In this review, we provide a detailed summary of the biogenesis, function, and chemical modification of tsRNAs, focusing on the current status and prospects of research on tsRNAs in neurodegenerative diseases, stroke, glioma, epilepsy, and others.https://doi.org/10.1002/ctd2.221biomarkerepilepsygliomaneurodegenerative diseasesstroketsRNA |
| spellingShingle | Kaiying Yang Yu Sun Jie Zhao Chang He Xudong Pan Xiaoyan Zhu Biogenesis, function, and landscape of tsRNAs in central nervous system diseases Clinical and Translational Discovery biomarker epilepsy glioma neurodegenerative diseases stroke tsRNA |
| title | Biogenesis, function, and landscape of tsRNAs in central nervous system diseases |
| title_full | Biogenesis, function, and landscape of tsRNAs in central nervous system diseases |
| title_fullStr | Biogenesis, function, and landscape of tsRNAs in central nervous system diseases |
| title_full_unstemmed | Biogenesis, function, and landscape of tsRNAs in central nervous system diseases |
| title_short | Biogenesis, function, and landscape of tsRNAs in central nervous system diseases |
| title_sort | biogenesis function and landscape of tsrnas in central nervous system diseases |
| topic | biomarker epilepsy glioma neurodegenerative diseases stroke tsRNA |
| url | https://doi.org/10.1002/ctd2.221 |
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