Re-assessing ZNF331 as a DNA methylation biomarker for colorectal cancer
Abstract We have previously shown that aberrant promoter methylation of ZNF331 is a potential biomarker for colorectal cancer detection with high sensitivity (71%) and specificity (98%). This finding was recently confirmed by others, and it was additionally suggested that promoter methylation of ZNF...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-05-01
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| Series: | Clinical Epigenetics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13148-018-0503-2 |
| _version_ | 1818933003321081856 |
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| author | Hege Marie Vedeld Arild Nesbakken Ragnhild A. Lothe Guro E. Lind |
| author_facet | Hege Marie Vedeld Arild Nesbakken Ragnhild A. Lothe Guro E. Lind |
| author_sort | Hege Marie Vedeld |
| collection | DOAJ |
| description | Abstract We have previously shown that aberrant promoter methylation of ZNF331 is a potential biomarker for colorectal cancer detection with high sensitivity (71%) and specificity (98%). This finding was recently confirmed by others, and it was additionally suggested that promoter methylation of ZNF331 was an independent prognostic biomarker for colorectal cancer (n = 146). In the current study, our initial colorectal cancer sample series was extended to include a total of 423 cancer tissue samples. Aberrant promoter methylation was found in 71% of the samples, thus repeatedly suggesting the biomarker potential of ZNF331 for detection of colorectal cancer. Furthermore, multivariate Cox’s analysis indicated a trend towards inferior overall survival for colorectal cancer patients with aberrant methylation of ZNF331. |
| first_indexed | 2024-12-20T04:41:28Z |
| format | Article |
| id | doaj.art-2d5d6a5262e748b1967fe6a5c5759427 |
| institution | Directory Open Access Journal |
| issn | 1868-7075 1868-7083 |
| language | English |
| last_indexed | 2024-12-20T04:41:28Z |
| publishDate | 2018-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Clinical Epigenetics |
| spelling | doaj.art-2d5d6a5262e748b1967fe6a5c57594272022-12-21T19:53:06ZengBMCClinical Epigenetics1868-70751868-70832018-05-011011410.1186/s13148-018-0503-2Re-assessing ZNF331 as a DNA methylation biomarker for colorectal cancerHege Marie Vedeld0Arild Nesbakken1Ragnhild A. Lothe2Guro E. Lind3Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital–Norwegian Radium HospitalK.G. Jebsen Colorectal Cancer Research Centre, Oslo University HospitalDepartment of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital–Norwegian Radium HospitalDepartment of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital–Norwegian Radium HospitalAbstract We have previously shown that aberrant promoter methylation of ZNF331 is a potential biomarker for colorectal cancer detection with high sensitivity (71%) and specificity (98%). This finding was recently confirmed by others, and it was additionally suggested that promoter methylation of ZNF331 was an independent prognostic biomarker for colorectal cancer (n = 146). In the current study, our initial colorectal cancer sample series was extended to include a total of 423 cancer tissue samples. Aberrant promoter methylation was found in 71% of the samples, thus repeatedly suggesting the biomarker potential of ZNF331 for detection of colorectal cancer. Furthermore, multivariate Cox’s analysis indicated a trend towards inferior overall survival for colorectal cancer patients with aberrant methylation of ZNF331.http://link.springer.com/article/10.1186/s13148-018-0503-2Colorectal cancerDiagnosisDNA methylationPrognosisZNF331 |
| spellingShingle | Hege Marie Vedeld Arild Nesbakken Ragnhild A. Lothe Guro E. Lind Re-assessing ZNF331 as a DNA methylation biomarker for colorectal cancer Clinical Epigenetics Colorectal cancer Diagnosis DNA methylation Prognosis ZNF331 |
| title | Re-assessing ZNF331 as a DNA methylation biomarker for colorectal cancer |
| title_full | Re-assessing ZNF331 as a DNA methylation biomarker for colorectal cancer |
| title_fullStr | Re-assessing ZNF331 as a DNA methylation biomarker for colorectal cancer |
| title_full_unstemmed | Re-assessing ZNF331 as a DNA methylation biomarker for colorectal cancer |
| title_short | Re-assessing ZNF331 as a DNA methylation biomarker for colorectal cancer |
| title_sort | re assessing znf331 as a dna methylation biomarker for colorectal cancer |
| topic | Colorectal cancer Diagnosis DNA methylation Prognosis ZNF331 |
| url | http://link.springer.com/article/10.1186/s13148-018-0503-2 |
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