The Small GTPase Rab7 Regulates Antigen Processing in B Cells in a Possible Interplay with Autophagy Machinery

The Small GTPase Rab7 Regulates Antigen Processing in B Cells in a Possible Interplay with Autophagy Machinery

In B cells, antigen processing and peptide-antigen (pAg) presentation is essential to ignite high-affinity antibody responses with the help of cognate T cells. B cells efficiently internalize and direct specific antigens for processing and loading onto MHCII. This critical step, which enables pAg pr...

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Bibliographic Details
Main Authors: Marika Runsala, Elina Kuokkanen, Eveliina Uski, Vid Šuštar, Meryem Özge Balci, Johanna Rajala, Vilma Paavola, Pieta K. Mattila
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cells
Subjects:
adaptive immune system
B cell activation
antigen processing
vesicle traffic
B cell receptor
BCR
Online Access:https://www.mdpi.com/2073-4409/12/21/2566

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