Molecular networking as a natural products discovery strategy

The rapid development of bioinformatics tools has recently broken through the bottleneck in natural products research. These advances have enabled natural products researchers to rapidly separate and efficiently target and discover previously undescribed molecules. Among these advances, tandem mass...

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Main Authors: Mi Zhang, Kouharu Otsuki, Wei Li
Format: Article
Language:English
Published: Compuscript Ltd 2023-04-01
Series:Acta Materia Medica
Subjects:
Online Access:https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2023-0007
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author Mi Zhang
Kouharu Otsuki
Wei Li
author_facet Mi Zhang
Kouharu Otsuki
Wei Li
author_sort Mi Zhang
collection DOAJ
description The rapid development of bioinformatics tools has recently broken through the bottleneck in natural products research. These advances have enabled natural products researchers to rapidly separate and efficiently target and discover previously undescribed molecules. Among these advances, tandem mass spectrometry molecular networking is a promising method for rapidly de-replicating complex natural mixtures, thus leading to an accelerated revolution in the “art of natural products isolation” field. In this review we describe the current molecular networking-based metabolite analysis methods that are widely applied or implementable in natural products discovery research, metabolomics, and related fields. The main objective of this review was to summarize strategies that can be rapidly implemented as alternative de-replication approaches for efficient natural products discovery and to list examples of successful applications that combine networking with other techniques.
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spelling doaj.art-2d5db65c52004d4d920999030d832d3d2023-09-26T08:59:51ZengCompuscript LtdActa Materia Medica2737-79462023-04-012212614110.15212/AMM-2023-0007Molecular networking as a natural products discovery strategyMi Zhang0Kouharu Otsuki1Wei Li2Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, JapanFaculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, JapanFaculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, JapanThe rapid development of bioinformatics tools has recently broken through the bottleneck in natural products research. These advances have enabled natural products researchers to rapidly separate and efficiently target and discover previously undescribed molecules. Among these advances, tandem mass spectrometry molecular networking is a promising method for rapidly de-replicating complex natural mixtures, thus leading to an accelerated revolution in the “art of natural products isolation” field. In this review we describe the current molecular networking-based metabolite analysis methods that are widely applied or implementable in natural products discovery research, metabolomics, and related fields. The main objective of this review was to summarize strategies that can be rapidly implemented as alternative de-replication approaches for efficient natural products discovery and to list examples of successful applications that combine networking with other techniques.https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2023-0007molecular networkingnatural productsde-replication strategies
spellingShingle Mi Zhang
Kouharu Otsuki
Wei Li
Molecular networking as a natural products discovery strategy
Acta Materia Medica
molecular networking
natural products
de-replication strategies
title Molecular networking as a natural products discovery strategy
title_full Molecular networking as a natural products discovery strategy
title_fullStr Molecular networking as a natural products discovery strategy
title_full_unstemmed Molecular networking as a natural products discovery strategy
title_short Molecular networking as a natural products discovery strategy
title_sort molecular networking as a natural products discovery strategy
topic molecular networking
natural products
de-replication strategies
url https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2023-0007
work_keys_str_mv AT mizhang molecularnetworkingasanaturalproductsdiscoverystrategy
AT kouharuotsuki molecularnetworkingasanaturalproductsdiscoverystrategy
AT weili molecularnetworkingasanaturalproductsdiscoverystrategy