Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps
Efflux transporters of the RND family confer resistance to multiple antibiotics in Gram-negative bacteria. Here, the authors identify pyridylpiperazine-based compounds that potentiate antibiotic activity in E. coli through allosteric inhibition of its primary RND transporter.
Bibliographic Details
| Main Authors: |
Coline Plé,
Heng-Keat Tam,
Anais Vieira Da Cruz,
Nina Compagne,
Juan-Carlos Jiménez-Castellanos,
Reinke T. Müller,
Elizabeth Pradel,
Wuen Ee Foong,
Giuliano Malloci,
Alexia Ballée,
Moritz A. Kirchner,
Parisa Moshfegh,
Adrien Herledan,
Andrea Herrmann,
Benoit Deprez,
Nicolas Willand,
Attilio Vittorio Vargiu,
Klaas M. Pos,
Marion Flipo,
Ruben C. Hartkoorn |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-27726-2
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