Disrupted interhemispheric coordination of sensory-motor networks and insula in major depressive disorder
ObjectivePrior researches have identified distinct differences in neuroimaging characteristics between healthy controls (HCs) and patients with major depressive disorder (MDD). However, the correlations between homotopic connectivity and clinical characteristics in patients with MDD have yet to be f...
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1135337/full |
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| author | Chunguo Zhang Huan Jing Haohao Yan Xiaoling Li Jiaquan Liang Qinqin Zhang Wenting Liang Yangpan Ou Can Peng Yang Yu Weibin Wu Guojun Xie Wenbin Guo |
| author_facet | Chunguo Zhang Huan Jing Haohao Yan Xiaoling Li Jiaquan Liang Qinqin Zhang Wenting Liang Yangpan Ou Can Peng Yang Yu Weibin Wu Guojun Xie Wenbin Guo |
| author_sort | Chunguo Zhang |
| collection | DOAJ |
| description | ObjectivePrior researches have identified distinct differences in neuroimaging characteristics between healthy controls (HCs) and patients with major depressive disorder (MDD). However, the correlations between homotopic connectivity and clinical characteristics in patients with MDD have yet to be fully understood. The present study aimed to investigate common and unique patterns of homotopic connectivity and their relationships with clinical characteristics in patients with MDD.MethodsWe recruited 42 patients diagnosed with MDD and 42 HCs. We collected a range of clinical variables, as well as exploratory eye movement (EEM), event-related potentials (ERPs) and resting-state functional magnetic resonance imaging (rs-fMRI) data. The data were analyzed using correlation analysis, support vector machine (SVM), and voxel-mirrored homotopic connectivity (VMHC).ResultsCompared with HCs, patients with MDD showed decreased VMHC in the insula, and increased VMHC in the cerebellum 8/vermis 8/vermis 9 and superior/middle occipital gyrus. SVM analysis using VMHC values in the cerebellum 8/vermis 8/vermis 9 and insula, or VMHC values in the superior/middle occipital gyrus and insula as inputs can distinguish HCs and patients with MDD with high accuracy, sensitivity, and specificity.ConclusionThe study demonstrated that decreased VMHC in the insula and increased VMHC values in the sensory-motor networks may be a distinctive neurobiological feature for patients with MDD, which could potentially serve as imaging markers to discriminate HCs and patients with MDD. |
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| language | English |
| last_indexed | 2024-04-10T05:32:10Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-2d5f724966934a89a13db01c4a769fd72023-03-07T05:36:05ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-03-011710.3389/fnins.2023.11353371135337Disrupted interhemispheric coordination of sensory-motor networks and insula in major depressive disorderChunguo Zhang0Huan Jing1Haohao Yan2Xiaoling Li3Jiaquan Liang4Qinqin Zhang5Wenting Liang6Yangpan Ou7Can Peng8Yang Yu9Weibin Wu10Guojun Xie11Wenbin Guo12Department of Psychiatry, The Third People’s Hospital of Foshan, Foshan, Guangdong, ChinaDepartment of Psychiatry, The Third People’s Hospital of Foshan, Foshan, Guangdong, ChinaDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Psychiatry, The Third People’s Hospital of Foshan, Foshan, Guangdong, ChinaDepartment of Psychiatry, The Third People’s Hospital of Foshan, Foshan, Guangdong, ChinaDepartment of Psychiatry, The Third People’s Hospital of Foshan, Foshan, Guangdong, ChinaDepartment of Psychiatry, The Third People’s Hospital of Foshan, Foshan, Guangdong, ChinaDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Psychiatry, The Third People’s Hospital of Foshan, Foshan, Guangdong, ChinaDepartment of Psychiatry, The Third People’s Hospital of Foshan, Foshan, Guangdong, ChinaDepartment of Psychiatry, The Third People’s Hospital of Foshan, Foshan, Guangdong, ChinaDepartment of Psychiatry, The Third People’s Hospital of Foshan, Foshan, Guangdong, ChinaDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaObjectivePrior researches have identified distinct differences in neuroimaging characteristics between healthy controls (HCs) and patients with major depressive disorder (MDD). However, the correlations between homotopic connectivity and clinical characteristics in patients with MDD have yet to be fully understood. The present study aimed to investigate common and unique patterns of homotopic connectivity and their relationships with clinical characteristics in patients with MDD.MethodsWe recruited 42 patients diagnosed with MDD and 42 HCs. We collected a range of clinical variables, as well as exploratory eye movement (EEM), event-related potentials (ERPs) and resting-state functional magnetic resonance imaging (rs-fMRI) data. The data were analyzed using correlation analysis, support vector machine (SVM), and voxel-mirrored homotopic connectivity (VMHC).ResultsCompared with HCs, patients with MDD showed decreased VMHC in the insula, and increased VMHC in the cerebellum 8/vermis 8/vermis 9 and superior/middle occipital gyrus. SVM analysis using VMHC values in the cerebellum 8/vermis 8/vermis 9 and insula, or VMHC values in the superior/middle occipital gyrus and insula as inputs can distinguish HCs and patients with MDD with high accuracy, sensitivity, and specificity.ConclusionThe study demonstrated that decreased VMHC in the insula and increased VMHC values in the sensory-motor networks may be a distinctive neurobiological feature for patients with MDD, which could potentially serve as imaging markers to discriminate HCs and patients with MDD.https://www.frontiersin.org/articles/10.3389/fnins.2023.1135337/fullmajor depressive disordervoxel-mirrored homotopic connectivitysupport vector machinemagnetic resonance imagingbrain |
| spellingShingle | Chunguo Zhang Huan Jing Haohao Yan Xiaoling Li Jiaquan Liang Qinqin Zhang Wenting Liang Yangpan Ou Can Peng Yang Yu Weibin Wu Guojun Xie Wenbin Guo Disrupted interhemispheric coordination of sensory-motor networks and insula in major depressive disorder Frontiers in Neuroscience major depressive disorder voxel-mirrored homotopic connectivity support vector machine magnetic resonance imaging brain |
| title | Disrupted interhemispheric coordination of sensory-motor networks and insula in major depressive disorder |
| title_full | Disrupted interhemispheric coordination of sensory-motor networks and insula in major depressive disorder |
| title_fullStr | Disrupted interhemispheric coordination of sensory-motor networks and insula in major depressive disorder |
| title_full_unstemmed | Disrupted interhemispheric coordination of sensory-motor networks and insula in major depressive disorder |
| title_short | Disrupted interhemispheric coordination of sensory-motor networks and insula in major depressive disorder |
| title_sort | disrupted interhemispheric coordination of sensory motor networks and insula in major depressive disorder |
| topic | major depressive disorder voxel-mirrored homotopic connectivity support vector machine magnetic resonance imaging brain |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1135337/full |
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