Low Cerebrospinal Fluid Levels of Melanotransferrin Are Associated With Conversion of Mild Cognitively Impaired Subjects to Alzheimer’s Disease

Low Cerebrospinal Fluid Levels of Melanotransferrin Are Associated With Conversion of Mild Cognitively Impaired Subjects to Alzheimer’s Disease

The disruption of iron metabolism and iron transport proteins have been implicated in the pathogenesis of Alzheimer’s disease (AD). Serum melanotransferrin (MTf), a transferrin homolog capable of reversibly binding iron, has been proposed as a biochemical marker of AD. MTf has also been shown to be...

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Bibliographic Details
Main Authors: Azhaar Ashraf, Jose Andres Alepuz Guillen, Manal Aljuhani, Chantal Hubens, Po-Wah So
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer’s disease
CSF
iron
MCI
melanotransferrin
microglia
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00181/full

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