Immunobiological Characteristics of the Attenuated African Swine Fever Virus Strain Katanga-350
The African swine fever virus (ASFV) is the cause of a recent pandemic that is threatening the global pig industry. The virus infects domestic and wild pigs and manifests with a variety of clinical symptoms, depending on the strain. No commercial vaccine is currently available to protect animals fro...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/8/1630 |
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| author | Alexey D. Sereda Mikhail E. Vlasov Galina S. Koltsova Sergey Y. Morgunov Dmitry A. Kudrjashov Irina P. Sindryakova Olga L. Kolbasova Valentina M. Lyska Andrei Y. Koltsov Sergey P. Zhivoderov Elena Y. Pivova Vladimir M. Baluishev Andrey E. Gogin Denis V. Kolbasov |
| author_facet | Alexey D. Sereda Mikhail E. Vlasov Galina S. Koltsova Sergey Y. Morgunov Dmitry A. Kudrjashov Irina P. Sindryakova Olga L. Kolbasova Valentina M. Lyska Andrei Y. Koltsov Sergey P. Zhivoderov Elena Y. Pivova Vladimir M. Baluishev Andrey E. Gogin Denis V. Kolbasov |
| author_sort | Alexey D. Sereda |
| collection | DOAJ |
| description | The African swine fever virus (ASFV) is the cause of a recent pandemic that is threatening the global pig industry. The virus infects domestic and wild pigs and manifests with a variety of clinical symptoms, depending on the strain. No commercial vaccine is currently available to protect animals from this virus, but some attenuated and recombinant live vaccine candidates might be effective against the disease. This article describes the immunobiological characteristics of one such candidate—the laboratory-attenuated ASFV strain, Katanga-350—which belongs to genotype I. In this study, we assessed clinical signs and post-mortem changes, the levels of viremia and the presence of viral DNA caused by injection of ASF virus strains Katanga-350, Lisbon-57, and Stavropol 08/01. Intramuscular injection of this strain protected 80% of pigs from a virulent strain of the same genotype and seroimmunotype (Lisbon-57). At least 50% of the surviving pigs received protection from subsequent intramuscular infection with a heterologous (genotype II, seroimmunotype VIII) virulent strain (Stavropol 08/01). Virus-specific antibodies were detectable in serum and saliva samples between 8–78 days after the first inoculation of the Katanga-350 strain (the observational period). The results suggested that this strain could serve as a basis for the development of a recombinant vaccine against ASF viruses belonging to seroimmunotype I. |
| first_indexed | 2024-03-09T03:43:11Z |
| format | Article |
| id | doaj.art-2d6067b4860c4840a3b3b3f9085be917 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T03:43:11Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-2d6067b4860c4840a3b3b3f9085be9172023-12-03T14:37:25ZengMDPI AGViruses1999-49152022-07-01148163010.3390/v14081630Immunobiological Characteristics of the Attenuated African Swine Fever Virus Strain Katanga-350Alexey D. Sereda0Mikhail E. Vlasov1Galina S. Koltsova2Sergey Y. Morgunov3Dmitry A. Kudrjashov4Irina P. Sindryakova5Olga L. Kolbasova6Valentina M. Lyska7Andrei Y. Koltsov8Sergey P. Zhivoderov9Elena Y. Pivova10Vladimir M. Baluishev11Andrey E. Gogin12Denis V. Kolbasov13Federal Research Center for Virology and Microbiology (FRCVIM), Petushki District, Vladimir Region, 601125 Volginsky, RussiaFederal Research Center for Virology and Microbiology (FRCVIM), Petushki District, Vladimir Region, 601125 Volginsky, RussiaFederal Research Center for Virology and Microbiology (FRCVIM), Petushki District, Vladimir Region, 601125 Volginsky, RussiaFederal Research Center for Virology and Microbiology (FRCVIM), Petushki District, Vladimir Region, 601125 Volginsky, RussiaFederal Research Center for Virology and Microbiology (FRCVIM), Petushki District, Vladimir Region, 601125 Volginsky, RussiaFederal Research Center for Virology and Microbiology (FRCVIM), Petushki District, Vladimir Region, 601125 Volginsky, RussiaFederal Research Center for Virology and Microbiology (FRCVIM), Petushki District, Vladimir Region, 601125 Volginsky, RussiaFederal Research Center for Virology and Microbiology (FRCVIM), Petushki District, Vladimir Region, 601125 Volginsky, RussiaFederal Research Center for Virology and Microbiology (FRCVIM), Petushki District, Vladimir Region, 601125 Volginsky, RussiaFederal Research Center for Virology and Microbiology (FRCVIM), Petushki District, Vladimir Region, 601125 Volginsky, RussiaFederal Research Center for Virology and Microbiology (FRCVIM), Petushki District, Vladimir Region, 601125 Volginsky, RussiaFederal Research Center for Virology and Microbiology (FRCVIM), Petushki District, Vladimir Region, 601125 Volginsky, RussiaFederal Research Center for Virology and Microbiology (FRCVIM), Petushki District, Vladimir Region, 601125 Volginsky, RussiaFederal Research Center for Virology and Microbiology (FRCVIM), Petushki District, Vladimir Region, 601125 Volginsky, RussiaThe African swine fever virus (ASFV) is the cause of a recent pandemic that is threatening the global pig industry. The virus infects domestic and wild pigs and manifests with a variety of clinical symptoms, depending on the strain. No commercial vaccine is currently available to protect animals from this virus, but some attenuated and recombinant live vaccine candidates might be effective against the disease. This article describes the immunobiological characteristics of one such candidate—the laboratory-attenuated ASFV strain, Katanga-350—which belongs to genotype I. In this study, we assessed clinical signs and post-mortem changes, the levels of viremia and the presence of viral DNA caused by injection of ASF virus strains Katanga-350, Lisbon-57, and Stavropol 08/01. Intramuscular injection of this strain protected 80% of pigs from a virulent strain of the same genotype and seroimmunotype (Lisbon-57). At least 50% of the surviving pigs received protection from subsequent intramuscular infection with a heterologous (genotype II, seroimmunotype VIII) virulent strain (Stavropol 08/01). Virus-specific antibodies were detectable in serum and saliva samples between 8–78 days after the first inoculation of the Katanga-350 strain (the observational period). The results suggested that this strain could serve as a basis for the development of a recombinant vaccine against ASF viruses belonging to seroimmunotype I.https://www.mdpi.com/1999-4915/14/8/1630African swine fever virusseroimmunotypegenotypeattenuated strainsimmunobiological characteristicsprotective immunity |
| spellingShingle | Alexey D. Sereda Mikhail E. Vlasov Galina S. Koltsova Sergey Y. Morgunov Dmitry A. Kudrjashov Irina P. Sindryakova Olga L. Kolbasova Valentina M. Lyska Andrei Y. Koltsov Sergey P. Zhivoderov Elena Y. Pivova Vladimir M. Baluishev Andrey E. Gogin Denis V. Kolbasov Immunobiological Characteristics of the Attenuated African Swine Fever Virus Strain Katanga-350 Viruses African swine fever virus seroimmunotype genotype attenuated strains immunobiological characteristics protective immunity |
| title | Immunobiological Characteristics of the Attenuated African Swine Fever Virus Strain Katanga-350 |
| title_full | Immunobiological Characteristics of the Attenuated African Swine Fever Virus Strain Katanga-350 |
| title_fullStr | Immunobiological Characteristics of the Attenuated African Swine Fever Virus Strain Katanga-350 |
| title_full_unstemmed | Immunobiological Characteristics of the Attenuated African Swine Fever Virus Strain Katanga-350 |
| title_short | Immunobiological Characteristics of the Attenuated African Swine Fever Virus Strain Katanga-350 |
| title_sort | immunobiological characteristics of the attenuated african swine fever virus strain katanga 350 |
| topic | African swine fever virus seroimmunotype genotype attenuated strains immunobiological characteristics protective immunity |
| url | https://www.mdpi.com/1999-4915/14/8/1630 |
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