p53 status modifies cytotoxic activity of lactoferrin under hypoxic conditions

p53 status modifies cytotoxic activity of lactoferrin under hypoxic conditions

Lactoferrin (LF) is an iron binding glycoprotein of the transferrin family with a wide spectrum of biological effects, including anti-cancer activity. However, the detailed molecular mechanisms of anti-cancer activity of LF have not been fully determined. In this study, we tried to clarify cytotoxic...

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Bibliographic Details
Main Authors: Maryami Yuliana Kosim, Takahiro Fukazawa, Mutsumi Miyauchi, Nobuyuki Hirohashi, Keiji Tanimoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
lactoferrin
cytotoxic activity
hypoxia
p53
ferroptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.988335/full

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