Plasmodium male gametocyte development and transmission are critically regulated by the two putative deadenylases of the CAF1/CCR4/NOT complex.
With relatively few known specific transcription factors to control the abundance of specific mRNAs, Plasmodium parasites may rely more on the regulation of transcript stability and turnover to provide sufficient gene regulation. Plasmodium transmission stages impose translational repression on spec...
Main Authors: | Kevin J Hart, Jenna Oberstaller, Michael P Walker, Allen M Minns, Mark F Kennedy, Ian Padykula, John H Adams, Scott E Lindner |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2019-01-01
|
Series: | PLoS Pathogens |
Online Access: | https://doi.org/10.1371/journal.ppat.1007164 |
Similar Items
-
Targeting Gametocytes of the Malaria Parasite <i>Plasmodium falciparum</i> in a Functional Genomics Era: Next Steps
by: Jyotsna Chawla, et al.
Published: (2021-03-01) -
The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.
by: Rachel Doidge, et al.
Published: (2012-01-01) -
Human Ccr4 and Caf1 Deadenylases Regulate Proliferation and Tumorigenicity of Human Gastric Cancer Cells via Modulating Cell Cycle Progression
by: Xiao-Hui Song, et al.
Published: (2021-02-01) -
Biochemical and biophysical characterization of the deadenylase CrCaf1 from Chlamydomonas reinhardtii.
by: Jia-Quan Zhang, et al.
Published: (2013-01-01) -
MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment.
by: Marchese, F, et al.
Published: (2010)