Hyperconnectivity of the lateral amygdala in long-term methamphetamine abstainers negatively correlated with withdrawal duration
Introduction: Several studies have reported structural and functional abnormalities of the amygdala caused by methamphetamine addiction. However, it is unknown whether abnormalities in amygdala function persist in long-term methamphetamine abstainers.Methods: In this study, 38 long-term male methamp...
| Main Authors: | , , , , , , , , , , , , , |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1138704/full |
| _version_ | 1797629404365455360 |
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| author | Yifan Li Xuhao Wang Shucai Huang Qiuping Huang Ru Yang Zhenjiang Liao Xinxin Chen Shuhong Lin Yongyan Shi Chenhan Wang Ying Tang Jingyue Hao Jie Yang Hongxian Shen |
| author_facet | Yifan Li Xuhao Wang Shucai Huang Qiuping Huang Ru Yang Zhenjiang Liao Xinxin Chen Shuhong Lin Yongyan Shi Chenhan Wang Ying Tang Jingyue Hao Jie Yang Hongxian Shen |
| author_sort | Yifan Li |
| collection | DOAJ |
| description | Introduction: Several studies have reported structural and functional abnormalities of the amygdala caused by methamphetamine addiction. However, it is unknown whether abnormalities in amygdala function persist in long-term methamphetamine abstainers.Methods: In this study, 38 long-term male methamphetamine abstainers (>12 months) and 40 demographically matched male healthy controls (HCs) were recruited. Considering the heterogeneous nature of the amygdala structure and function, we chose 4 amygdala subregions (i.e., left lateral, left medial, right lateral, and right medial) as regions of interest (ROI) and compared the ROI-based resting-state functional connectivity (FC) at the whole-brain voxel-wise between the two groups. We explored the relationship between the detected abnormal connectivity, methamphetamine use factors, and the duration of withdrawal using correlation analyses. We also examined the effect of methamphetamine use factors, months of withdrawal, and sociodemographic data on detected abnormal connectivity through multiple linear regressions.Results: Compared with HCs, long-term methamphetamine abstainers showed significant hyperconnectivity between the left lateral amygdala and a continuous area extending to the left inferior/middle occipital gyrus and left middle/superior temporal gyrus. Abnormal connections negatively correlated with methamphetamine withdrawal time (r = −0.85, p < 0.001). The linear regression model further demonstrated that the months of withdrawal could identify the abnormal connectivity (βadj = −0.86, 95%CI: −1.06 to −0.65, p < 0.001).Discussion: The use of methamphetamine can impair the neural sensory system, including the visual and auditory systems, but this abnormal connectivity can gradually recover after prolonged withdrawal of methamphetamine. From a neuroimaging perspective, our results suggest that withdrawal is an effective treatment for methamphetamine. |
| first_indexed | 2024-03-11T10:53:51Z |
| format | Article |
| id | doaj.art-2d62ffef6d6a4951af9d19852f0b1915 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-11T10:53:51Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-2d62ffef6d6a4951af9d19852f0b19152023-11-13T12:25:38ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-11-011410.3389/fphar.2023.11387041138704Hyperconnectivity of the lateral amygdala in long-term methamphetamine abstainers negatively correlated with withdrawal durationYifan Li0Xuhao Wang1Shucai Huang2Qiuping Huang3Ru Yang4Zhenjiang Liao5Xinxin Chen6Shuhong Lin7Yongyan Shi8Chenhan Wang9Ying Tang10Jingyue Hao11Jie Yang12Hongxian Shen13Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Psychiatry, The Fourth People’s Hospital of Wuhu, Wuhu, Anhui, ChinaDepartment of Applied Psychology, School of Humanities and Management, Hunan University of Chinese Medicine, Changsha, ChinaDepartment of Radiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaThe First Clinical Medical College of Lanzhou University, Lanzhou, ChinaDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaIntroduction: Several studies have reported structural and functional abnormalities of the amygdala caused by methamphetamine addiction. However, it is unknown whether abnormalities in amygdala function persist in long-term methamphetamine abstainers.Methods: In this study, 38 long-term male methamphetamine abstainers (>12 months) and 40 demographically matched male healthy controls (HCs) were recruited. Considering the heterogeneous nature of the amygdala structure and function, we chose 4 amygdala subregions (i.e., left lateral, left medial, right lateral, and right medial) as regions of interest (ROI) and compared the ROI-based resting-state functional connectivity (FC) at the whole-brain voxel-wise between the two groups. We explored the relationship between the detected abnormal connectivity, methamphetamine use factors, and the duration of withdrawal using correlation analyses. We also examined the effect of methamphetamine use factors, months of withdrawal, and sociodemographic data on detected abnormal connectivity through multiple linear regressions.Results: Compared with HCs, long-term methamphetamine abstainers showed significant hyperconnectivity between the left lateral amygdala and a continuous area extending to the left inferior/middle occipital gyrus and left middle/superior temporal gyrus. Abnormal connections negatively correlated with methamphetamine withdrawal time (r = −0.85, p < 0.001). The linear regression model further demonstrated that the months of withdrawal could identify the abnormal connectivity (βadj = −0.86, 95%CI: −1.06 to −0.65, p < 0.001).Discussion: The use of methamphetamine can impair the neural sensory system, including the visual and auditory systems, but this abnormal connectivity can gradually recover after prolonged withdrawal of methamphetamine. From a neuroimaging perspective, our results suggest that withdrawal is an effective treatment for methamphetamine.https://www.frontiersin.org/articles/10.3389/fphar.2023.1138704/fulllong-term withdrawalfunctional connectivityamygdalaoccipital gyrustemporal gyrus |
| spellingShingle | Yifan Li Xuhao Wang Shucai Huang Qiuping Huang Ru Yang Zhenjiang Liao Xinxin Chen Shuhong Lin Yongyan Shi Chenhan Wang Ying Tang Jingyue Hao Jie Yang Hongxian Shen Hyperconnectivity of the lateral amygdala in long-term methamphetamine abstainers negatively correlated with withdrawal duration Frontiers in Pharmacology long-term withdrawal functional connectivity amygdala occipital gyrus temporal gyrus |
| title | Hyperconnectivity of the lateral amygdala in long-term methamphetamine abstainers negatively correlated with withdrawal duration |
| title_full | Hyperconnectivity of the lateral amygdala in long-term methamphetamine abstainers negatively correlated with withdrawal duration |
| title_fullStr | Hyperconnectivity of the lateral amygdala in long-term methamphetamine abstainers negatively correlated with withdrawal duration |
| title_full_unstemmed | Hyperconnectivity of the lateral amygdala in long-term methamphetamine abstainers negatively correlated with withdrawal duration |
| title_short | Hyperconnectivity of the lateral amygdala in long-term methamphetamine abstainers negatively correlated with withdrawal duration |
| title_sort | hyperconnectivity of the lateral amygdala in long term methamphetamine abstainers negatively correlated with withdrawal duration |
| topic | long-term withdrawal functional connectivity amygdala occipital gyrus temporal gyrus |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1138704/full |
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