A Potential Synbiotic Strategy for the Prevention of Type 2 Diabetes: <i>Lactobacillus paracasei</i> JY062 and Exopolysaccharide Isolated from <i>Lactobacillus plantarum</i> JY039
The disturbance of intestinal microorganisms and the exacerbation of type 2 diabetes (T2D) are mutually influenced. In this study, the effect of exopolysaccharides (EPS) from <i>Lactobacillus plantarum</i> JY039 on the adhesion of <i>Lactobacillus paracasei</i> JY062 was inve...
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| Format: | Article |
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MDPI AG
2022-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/2/377 |
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| author | Jiayuan Zhao Lihan Wang Shasha Cheng Yu Zhang Mo Yang Ruxue Fang Hongxuan Li Chaoxin Man Yujun Jiang |
| author_facet | Jiayuan Zhao Lihan Wang Shasha Cheng Yu Zhang Mo Yang Ruxue Fang Hongxuan Li Chaoxin Man Yujun Jiang |
| author_sort | Jiayuan Zhao |
| collection | DOAJ |
| description | The disturbance of intestinal microorganisms and the exacerbation of type 2 diabetes (T2D) are mutually influenced. In this study, the effect of exopolysaccharides (EPS) from <i>Lactobacillus plantarum</i> JY039 on the adhesion of <i>Lactobacillus paracasei</i> JY062 was investigated, as well as their preventive efficacy against T2D. The results showed that the EPS isolated from <i>L. plantarum</i> JY039 effectively improved the adhesion rate of <i>L. paracasei</i> JY062 to Caco-2 cells (1.8 times) and promoted the proliferation of <i>L. paracasei</i> JY062. In the mice experiment, EPS, <i>L. paracasei</i> JY062 and their complex altered the structure of the intestinal microbiota, which elevated the proportion of <i>Bifidobacterium</i>, <i>Faecalibaculum</i>, while inversely decreasing the proportion of <i>Firmicutes</i>, <i>Muribaculaceae, Lachnospiraceae</i> and other bacteria involved in energy metabolism (<i>p</i> < 0.01; <i>p</i> < 0.05); enhanced the intestinal barrier function; promoted secretion of the gut hormone peptide YY (PYY) and glucagon-like peptide-1 (GLP-1); and reduced inflammation by balancing pro-inflammatory factors IL-6, TNF-α and anti-inflammatory factor IL-10 (<i>p</i> < 0.01; <i>p</i> < 0.05). These results illustrate that EPS and <i>L. paracasei</i> JY062 have the synbiotic potential to prevent and alleviate T2D. |
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| series | Nutrients |
| spelling | doaj.art-2d641ccba3ec45c6a4aaec8a862864e02023-11-23T14:58:29ZengMDPI AGNutrients2072-66432022-01-0114237710.3390/nu14020377A Potential Synbiotic Strategy for the Prevention of Type 2 Diabetes: <i>Lactobacillus paracasei</i> JY062 and Exopolysaccharide Isolated from <i>Lactobacillus plantarum</i> JY039Jiayuan Zhao0Lihan Wang1Shasha Cheng2Yu Zhang3Mo Yang4Ruxue Fang5Hongxuan Li6Chaoxin Man7Yujun Jiang8Key Lab of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin 150030, ChinaKey Lab of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin 150030, ChinaKey Lab of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin 150030, ChinaKey Lab of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin 150030, ChinaKey Lab of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin 150030, ChinaKey Lab of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin 150030, ChinaKey Lab of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin 150030, ChinaKey Lab of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin 150030, ChinaKey Lab of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin 150030, ChinaThe disturbance of intestinal microorganisms and the exacerbation of type 2 diabetes (T2D) are mutually influenced. In this study, the effect of exopolysaccharides (EPS) from <i>Lactobacillus plantarum</i> JY039 on the adhesion of <i>Lactobacillus paracasei</i> JY062 was investigated, as well as their preventive efficacy against T2D. The results showed that the EPS isolated from <i>L. plantarum</i> JY039 effectively improved the adhesion rate of <i>L. paracasei</i> JY062 to Caco-2 cells (1.8 times) and promoted the proliferation of <i>L. paracasei</i> JY062. In the mice experiment, EPS, <i>L. paracasei</i> JY062 and their complex altered the structure of the intestinal microbiota, which elevated the proportion of <i>Bifidobacterium</i>, <i>Faecalibaculum</i>, while inversely decreasing the proportion of <i>Firmicutes</i>, <i>Muribaculaceae, Lachnospiraceae</i> and other bacteria involved in energy metabolism (<i>p</i> < 0.01; <i>p</i> < 0.05); enhanced the intestinal barrier function; promoted secretion of the gut hormone peptide YY (PYY) and glucagon-like peptide-1 (GLP-1); and reduced inflammation by balancing pro-inflammatory factors IL-6, TNF-α and anti-inflammatory factor IL-10 (<i>p</i> < 0.01; <i>p</i> < 0.05). These results illustrate that EPS and <i>L. paracasei</i> JY062 have the synbiotic potential to prevent and alleviate T2D.https://www.mdpi.com/2072-6643/14/2/377type 2 diabetesexopolysaccharidesynbioticintestinal microorganismintestinal barrier functioninflammation |
| spellingShingle | Jiayuan Zhao Lihan Wang Shasha Cheng Yu Zhang Mo Yang Ruxue Fang Hongxuan Li Chaoxin Man Yujun Jiang A Potential Synbiotic Strategy for the Prevention of Type 2 Diabetes: <i>Lactobacillus paracasei</i> JY062 and Exopolysaccharide Isolated from <i>Lactobacillus plantarum</i> JY039 Nutrients type 2 diabetes exopolysaccharide synbiotic intestinal microorganism intestinal barrier function inflammation |
| title | A Potential Synbiotic Strategy for the Prevention of Type 2 Diabetes: <i>Lactobacillus paracasei</i> JY062 and Exopolysaccharide Isolated from <i>Lactobacillus plantarum</i> JY039 |
| title_full | A Potential Synbiotic Strategy for the Prevention of Type 2 Diabetes: <i>Lactobacillus paracasei</i> JY062 and Exopolysaccharide Isolated from <i>Lactobacillus plantarum</i> JY039 |
| title_fullStr | A Potential Synbiotic Strategy for the Prevention of Type 2 Diabetes: <i>Lactobacillus paracasei</i> JY062 and Exopolysaccharide Isolated from <i>Lactobacillus plantarum</i> JY039 |
| title_full_unstemmed | A Potential Synbiotic Strategy for the Prevention of Type 2 Diabetes: <i>Lactobacillus paracasei</i> JY062 and Exopolysaccharide Isolated from <i>Lactobacillus plantarum</i> JY039 |
| title_short | A Potential Synbiotic Strategy for the Prevention of Type 2 Diabetes: <i>Lactobacillus paracasei</i> JY062 and Exopolysaccharide Isolated from <i>Lactobacillus plantarum</i> JY039 |
| title_sort | potential synbiotic strategy for the prevention of type 2 diabetes i lactobacillus paracasei i jy062 and exopolysaccharide isolated from i lactobacillus plantarum i jy039 |
| topic | type 2 diabetes exopolysaccharide synbiotic intestinal microorganism intestinal barrier function inflammation |
| url | https://www.mdpi.com/2072-6643/14/2/377 |
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