#166 : Investigating the Effect of Parental Age on Intracytoplasmic Sperm Injection Reproductive Outcomes in Indonesia: Prognostic Tools and Prediction Approaches to Maximize Human Embryo Implantation
Background and Aims: Reproductive issues impact one in eight Indonesian married couples. Intra Cytoplasmic Sperm Injection (ICSI) is still expensive; hence many couples don’t get evaluated or enroll fertility programs. We decided to study the correlation between age, hormonal status, and ICSI embryo...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
World Scientific Publishing
2023-12-01
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| Series: | Fertility & Reproduction |
| Online Access: | https://www.worldscientific.com/doi/10.1142/S2661318223743928 |
| _version_ | 1797237047997497344 |
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| author | Ria Margiana Geraldo Laurus Fatkhurrohmah Leo Amalia Supardi Supardi Muhammad Fadhli Abdullah Maitra Djiang Wen Suwaspodo Henry Wibowo Maya Sri Kamaroekmi |
| author_facet | Ria Margiana Geraldo Laurus Fatkhurrohmah Leo Amalia Supardi Supardi Muhammad Fadhli Abdullah Maitra Djiang Wen Suwaspodo Henry Wibowo Maya Sri Kamaroekmi |
| author_sort | Ria Margiana |
| collection | DOAJ |
| description | Background and Aims: Reproductive issues impact one in eight Indonesian married couples. Intra Cytoplasmic Sperm Injection (ICSI) is still expensive; hence many couples don’t get evaluated or enroll fertility programs. We decided to study the correlation between age, hormonal status, and ICSI embryo quality because Indonesia’s infertility rate is rising. This is the first investigation into the factors behind ICSI outcomes in Indonesia. Method: In 2022, two fertility centers in Surabaya and Tangerang, Indonesia, performed ICSI on couples. 150 couples receiving ICSI at two research sites comprise the sample. Surgically retrieved or frozen sperm cycles and incomplete medical records were excluded. The Spearman test was used to investigate the correlation between parental age, hormonal status, and ICSI embryo quality on day 1 and day 3. (D1 and D3). Results: 150 ICSI cycles were studied. The hormonal baseline varied from normal to subnormal, while paternal and maternal age ± SDs were 37.03 ± 6.08 and 34.28 ± 5.11. The Spearman test demonstrated a significant negative connection between paternal age and embryo quality D1 (p<0.005, r=-0.363) and D3 (good category: p<0.005, r=-0.172; intermediate category: p<0.005, r=-0.250; poor category: p<0.005, r=-0.221). The Spearman test showed a significant negative connection between maternal age and embryo quality D1 (p<0.005, r=-0.413) and D3 (good category: p<0.005, r=-0.231; intermediate category: p<0.005, r=-0.294; poor category: p<0.005, r=-0.291). Conclusion: This study reveals that married couples have a substantial impact on their hormonal condition, the rate of fertilization, the quality of D1 and D3 embryos, and the number of embryos generated following ICSI. To increase the success rate of ICSI procedures, it is necessary to maximize fertility at a younger age. |
| first_indexed | 2024-04-24T17:13:33Z |
| format | Article |
| id | doaj.art-2d652d549f2941219249d3b0ce811b76 |
| institution | Directory Open Access Journal |
| issn | 2661-3182 2661-3174 |
| language | English |
| last_indexed | 2024-04-24T17:13:33Z |
| publishDate | 2023-12-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Fertility & Reproduction |
| spelling | doaj.art-2d652d549f2941219249d3b0ce811b762024-03-28T07:54:17ZengWorld Scientific PublishingFertility & Reproduction2661-31822661-31742023-12-01050467567510.1142/S2661318223743928#166 : Investigating the Effect of Parental Age on Intracytoplasmic Sperm Injection Reproductive Outcomes in Indonesia: Prognostic Tools and Prediction Approaches to Maximize Human Embryo ImplantationRia Margiana0Geraldo Laurus1Fatkhurrohmah Leo Amalia2Supardi Supardi3Muhammad Fadhli Abdullah4Maitra Djiang Wen5Suwaspodo Henry Wibowo6Maya Sri Kamaroekmi7Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Central Jakarta, IndonesiaAndrology Program, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaAndrology Program, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaAndrology Program, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaAndrology Program, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaBocah Indonesia Fertility Center, Primaya Hospital, Tangerang, IndonesiaSignum Fertility Centre, Husada Utama Hospital, Surabaya, IndonesiaSignum Fertility Centre, Husada Utama Hospital, Surabaya, IndonesiaBackground and Aims: Reproductive issues impact one in eight Indonesian married couples. Intra Cytoplasmic Sperm Injection (ICSI) is still expensive; hence many couples don’t get evaluated or enroll fertility programs. We decided to study the correlation between age, hormonal status, and ICSI embryo quality because Indonesia’s infertility rate is rising. This is the first investigation into the factors behind ICSI outcomes in Indonesia. Method: In 2022, two fertility centers in Surabaya and Tangerang, Indonesia, performed ICSI on couples. 150 couples receiving ICSI at two research sites comprise the sample. Surgically retrieved or frozen sperm cycles and incomplete medical records were excluded. The Spearman test was used to investigate the correlation between parental age, hormonal status, and ICSI embryo quality on day 1 and day 3. (D1 and D3). Results: 150 ICSI cycles were studied. The hormonal baseline varied from normal to subnormal, while paternal and maternal age ± SDs were 37.03 ± 6.08 and 34.28 ± 5.11. The Spearman test demonstrated a significant negative connection between paternal age and embryo quality D1 (p<0.005, r=-0.363) and D3 (good category: p<0.005, r=-0.172; intermediate category: p<0.005, r=-0.250; poor category: p<0.005, r=-0.221). The Spearman test showed a significant negative connection between maternal age and embryo quality D1 (p<0.005, r=-0.413) and D3 (good category: p<0.005, r=-0.231; intermediate category: p<0.005, r=-0.294; poor category: p<0.005, r=-0.291). Conclusion: This study reveals that married couples have a substantial impact on their hormonal condition, the rate of fertilization, the quality of D1 and D3 embryos, and the number of embryos generated following ICSI. To increase the success rate of ICSI procedures, it is necessary to maximize fertility at a younger age.https://www.worldscientific.com/doi/10.1142/S2661318223743928 |
| spellingShingle | Ria Margiana Geraldo Laurus Fatkhurrohmah Leo Amalia Supardi Supardi Muhammad Fadhli Abdullah Maitra Djiang Wen Suwaspodo Henry Wibowo Maya Sri Kamaroekmi #166 : Investigating the Effect of Parental Age on Intracytoplasmic Sperm Injection Reproductive Outcomes in Indonesia: Prognostic Tools and Prediction Approaches to Maximize Human Embryo Implantation Fertility & Reproduction |
| title | #166 : Investigating the Effect of Parental Age on Intracytoplasmic Sperm Injection Reproductive Outcomes in Indonesia: Prognostic Tools and Prediction Approaches to Maximize Human Embryo Implantation |
| title_full | #166 : Investigating the Effect of Parental Age on Intracytoplasmic Sperm Injection Reproductive Outcomes in Indonesia: Prognostic Tools and Prediction Approaches to Maximize Human Embryo Implantation |
| title_fullStr | #166 : Investigating the Effect of Parental Age on Intracytoplasmic Sperm Injection Reproductive Outcomes in Indonesia: Prognostic Tools and Prediction Approaches to Maximize Human Embryo Implantation |
| title_full_unstemmed | #166 : Investigating the Effect of Parental Age on Intracytoplasmic Sperm Injection Reproductive Outcomes in Indonesia: Prognostic Tools and Prediction Approaches to Maximize Human Embryo Implantation |
| title_short | #166 : Investigating the Effect of Parental Age on Intracytoplasmic Sperm Injection Reproductive Outcomes in Indonesia: Prognostic Tools and Prediction Approaches to Maximize Human Embryo Implantation |
| title_sort | 166 investigating the effect of parental age on intracytoplasmic sperm injection reproductive outcomes in indonesia prognostic tools and prediction approaches to maximize human embryo implantation |
| url | https://www.worldscientific.com/doi/10.1142/S2661318223743928 |
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