Case Report: Management of Malignancy-Exacerbated Pemphigus Vulgaris During COVID-19 Pandemic
Pemphigus vulgaris is an intraepidermal autoimmune mucocutaneous blistering disease whose etiopathogenesis includes various trigger factors, i.e., drugs and malignancies. We present a case of malignancy-exacerbated pemphigus vulgaris which required a careful diagnostic process in order to rule out p...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-08-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.708284/full |
| _version_ | 1818572232969945088 |
|---|---|
| author | Alberto Corrà Francesca Cammelli Lavinia Quintarelli Lavinia Quintarelli Giuseppe Barbato Ornella Le Rose Adele Salemme Giovanni Di Zenzo Francesco Coratti Alice Verdelli Alice Verdelli Cristina Aimo Elena Biancamaria Mariotti Beatrice Bianchi Fabio Cianchi Marzia Caproni Marzia Caproni |
| author_facet | Alberto Corrà Francesca Cammelli Lavinia Quintarelli Lavinia Quintarelli Giuseppe Barbato Ornella Le Rose Adele Salemme Giovanni Di Zenzo Francesco Coratti Alice Verdelli Alice Verdelli Cristina Aimo Elena Biancamaria Mariotti Beatrice Bianchi Fabio Cianchi Marzia Caproni Marzia Caproni |
| author_sort | Alberto Corrà |
| collection | DOAJ |
| description | Pemphigus vulgaris is an intraepidermal autoimmune mucocutaneous blistering disease whose etiopathogenesis includes various trigger factors, i.e., drugs and malignancies. We present a case of malignancy-exacerbated pemphigus vulgaris which required a careful diagnostic process in order to rule out paraneoplastic pemphigus, along with the challenges posed by the need of treating both cutaneous and oncologic diseases. Possible post-operative complications post-poned the start of first-line immunosuppressive treatment of pemphigus. Moreover, the infective risks had to be minimized during the peak of the COVID-19 pandemic in Italy. Intravenous immunoglobulins were chosen as “bridge” therapy before the tumor surgical excision, followed by rituximab in post-operative phase. |
| first_indexed | 2024-12-14T18:54:22Z |
| format | Article |
| id | doaj.art-2d65d3c84aff4d40a802be21dfdf44bd |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-14T18:54:22Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-2d65d3c84aff4d40a802be21dfdf44bd2022-12-21T22:51:09ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-08-01810.3389/fmed.2021.708284708284Case Report: Management of Malignancy-Exacerbated Pemphigus Vulgaris During COVID-19 PandemicAlberto Corrà0Francesca Cammelli1Lavinia Quintarelli2Lavinia Quintarelli3Giuseppe Barbato4Ornella Le Rose5Adele Salemme6Giovanni Di Zenzo7Francesco Coratti8Alice Verdelli9Alice Verdelli10Cristina Aimo11Elena Biancamaria Mariotti12Beatrice Bianchi13Fabio Cianchi14Marzia Caproni15Marzia Caproni16Section of Dermatology, Department of Health Sciences, University of Florence, Florence, ItalyDivision of Gastrointestinal Surgery, Careggi University Hospital, Azienda Ospedaliero-Universitaria Careggi, Florence, ItalySection of Dermatology, Department of Health Sciences, University of Florence, Florence, ItalyRare Diseases Unit, Section of Dermatology, Department of Health Sciences, Azienda USL Toscana Centro, University of Florence, European Reference Network-Skin Member, Florence, ItalyDivision of Gastrointestinal Surgery, Careggi University Hospital, Azienda Ospedaliero-Universitaria Careggi, Florence, ItalySection of Radiology, Unità Sanitaria Locale Toscana Centro, “Piero Palagi” Hospital, Florence, ItalyMolecular and Cell Biology Laboratory, Istituto Dermopatico dell'Immacolata - Istituto di Ricovero e Cura a Carattere Scientifico, Rome, ItalyMolecular and Cell Biology Laboratory, Istituto Dermopatico dell'Immacolata - Istituto di Ricovero e Cura a Carattere Scientifico, Rome, ItalyDivision of Gastrointestinal Surgery, Careggi University Hospital, Azienda Ospedaliero-Universitaria Careggi, Florence, ItalySection of Dermatology, Department of Health Sciences, University of Florence, Florence, ItalyRare Diseases Unit, Section of Dermatology, Department of Health Sciences, Azienda USL Toscana Centro, University of Florence, European Reference Network-Skin Member, Florence, ItalySection of Dermatology, Department of Health Sciences, University of Florence, Florence, ItalySection of Dermatology, Department of Health Sciences, University of Florence, Florence, ItalySection of Dermatology, Department of Health Sciences, University of Florence, Florence, ItalyDivision of Gastrointestinal Surgery, Careggi University Hospital, Azienda Ospedaliero-Universitaria Careggi, Florence, ItalySection of Dermatology, Department of Health Sciences, University of Florence, Florence, ItalyRare Diseases Unit, Section of Dermatology, Department of Health Sciences, Azienda USL Toscana Centro, University of Florence, European Reference Network-Skin Member, Florence, ItalyPemphigus vulgaris is an intraepidermal autoimmune mucocutaneous blistering disease whose etiopathogenesis includes various trigger factors, i.e., drugs and malignancies. We present a case of malignancy-exacerbated pemphigus vulgaris which required a careful diagnostic process in order to rule out paraneoplastic pemphigus, along with the challenges posed by the need of treating both cutaneous and oncologic diseases. Possible post-operative complications post-poned the start of first-line immunosuppressive treatment of pemphigus. Moreover, the infective risks had to be minimized during the peak of the COVID-19 pandemic in Italy. Intravenous immunoglobulins were chosen as “bridge” therapy before the tumor surgical excision, followed by rituximab in post-operative phase.https://www.frontiersin.org/articles/10.3389/fmed.2021.708284/fullesophageal cancerpemphigus vulgarisrituximabintravenous immunoglobulinimmunoblotparaneoplastic pemphigus |
| spellingShingle | Alberto Corrà Francesca Cammelli Lavinia Quintarelli Lavinia Quintarelli Giuseppe Barbato Ornella Le Rose Adele Salemme Giovanni Di Zenzo Francesco Coratti Alice Verdelli Alice Verdelli Cristina Aimo Elena Biancamaria Mariotti Beatrice Bianchi Fabio Cianchi Marzia Caproni Marzia Caproni Case Report: Management of Malignancy-Exacerbated Pemphigus Vulgaris During COVID-19 Pandemic Frontiers in Medicine esophageal cancer pemphigus vulgaris rituximab intravenous immunoglobulin immunoblot paraneoplastic pemphigus |
| title | Case Report: Management of Malignancy-Exacerbated Pemphigus Vulgaris During COVID-19 Pandemic |
| title_full | Case Report: Management of Malignancy-Exacerbated Pemphigus Vulgaris During COVID-19 Pandemic |
| title_fullStr | Case Report: Management of Malignancy-Exacerbated Pemphigus Vulgaris During COVID-19 Pandemic |
| title_full_unstemmed | Case Report: Management of Malignancy-Exacerbated Pemphigus Vulgaris During COVID-19 Pandemic |
| title_short | Case Report: Management of Malignancy-Exacerbated Pemphigus Vulgaris During COVID-19 Pandemic |
| title_sort | case report management of malignancy exacerbated pemphigus vulgaris during covid 19 pandemic |
| topic | esophageal cancer pemphigus vulgaris rituximab intravenous immunoglobulin immunoblot paraneoplastic pemphigus |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.708284/full |
| work_keys_str_mv | AT albertocorra casereportmanagementofmalignancyexacerbatedpemphigusvulgarisduringcovid19pandemic AT francescacammelli casereportmanagementofmalignancyexacerbatedpemphigusvulgarisduringcovid19pandemic AT laviniaquintarelli casereportmanagementofmalignancyexacerbatedpemphigusvulgarisduringcovid19pandemic AT laviniaquintarelli casereportmanagementofmalignancyexacerbatedpemphigusvulgarisduringcovid19pandemic AT giuseppebarbato casereportmanagementofmalignancyexacerbatedpemphigusvulgarisduringcovid19pandemic AT ornellalerose casereportmanagementofmalignancyexacerbatedpemphigusvulgarisduringcovid19pandemic AT adelesalemme casereportmanagementofmalignancyexacerbatedpemphigusvulgarisduringcovid19pandemic AT giovannidizenzo casereportmanagementofmalignancyexacerbatedpemphigusvulgarisduringcovid19pandemic AT francescocoratti casereportmanagementofmalignancyexacerbatedpemphigusvulgarisduringcovid19pandemic AT aliceverdelli casereportmanagementofmalignancyexacerbatedpemphigusvulgarisduringcovid19pandemic AT aliceverdelli casereportmanagementofmalignancyexacerbatedpemphigusvulgarisduringcovid19pandemic AT cristinaaimo casereportmanagementofmalignancyexacerbatedpemphigusvulgarisduringcovid19pandemic AT elenabiancamariamariotti casereportmanagementofmalignancyexacerbatedpemphigusvulgarisduringcovid19pandemic AT beatricebianchi casereportmanagementofmalignancyexacerbatedpemphigusvulgarisduringcovid19pandemic AT fabiocianchi casereportmanagementofmalignancyexacerbatedpemphigusvulgarisduringcovid19pandemic AT marziacaproni casereportmanagementofmalignancyexacerbatedpemphigusvulgarisduringcovid19pandemic AT marziacaproni casereportmanagementofmalignancyexacerbatedpemphigusvulgarisduringcovid19pandemic |