Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia.
Twelve-hour (12 h) ultradian rhythms are a well-known phenomenon in coastal marine organisms. While 12 h cycles are observed in human behavior and physiology, no study has measured 12 h rhythms in the human brain. Here, we identify 12 h rhythms in transcripts that either peak at sleep/wake transitio...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3001688 |
| _version_ | 1827922402498052096 |
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| author | Madeline R Scott Wei Zong Kyle D Ketchesin Marianne L Seney George C Tseng Bokai Zhu Colleen A McClung |
| author_facet | Madeline R Scott Wei Zong Kyle D Ketchesin Marianne L Seney George C Tseng Bokai Zhu Colleen A McClung |
| author_sort | Madeline R Scott |
| collection | DOAJ |
| description | Twelve-hour (12 h) ultradian rhythms are a well-known phenomenon in coastal marine organisms. While 12 h cycles are observed in human behavior and physiology, no study has measured 12 h rhythms in the human brain. Here, we identify 12 h rhythms in transcripts that either peak at sleep/wake transitions (approximately 9 AM/PM) or static times (approximately 3 PM/AM) in the dorsolateral prefrontal cortex, a region involved in cognition. Subjects with schizophrenia (SZ) lose 12 h rhythms in genes associated with the unfolded protein response and neuronal structural maintenance. Moreover, genes involved in mitochondrial function and protein translation, which normally peak at sleep/wake transitions, peak instead at static times in SZ, suggesting suboptimal timing of these essential processes. |
| first_indexed | 2024-03-13T04:42:09Z |
| format | Article |
| id | doaj.art-2d696377f12e4c7ea7023dba6e4fe7d5 |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-03-13T04:42:09Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-2d696377f12e4c7ea7023dba6e4fe7d52023-06-19T05:30:30ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852023-01-01211e300168810.1371/journal.pbio.3001688Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia.Madeline R ScottWei ZongKyle D KetchesinMarianne L SeneyGeorge C TsengBokai ZhuColleen A McClungTwelve-hour (12 h) ultradian rhythms are a well-known phenomenon in coastal marine organisms. While 12 h cycles are observed in human behavior and physiology, no study has measured 12 h rhythms in the human brain. Here, we identify 12 h rhythms in transcripts that either peak at sleep/wake transitions (approximately 9 AM/PM) or static times (approximately 3 PM/AM) in the dorsolateral prefrontal cortex, a region involved in cognition. Subjects with schizophrenia (SZ) lose 12 h rhythms in genes associated with the unfolded protein response and neuronal structural maintenance. Moreover, genes involved in mitochondrial function and protein translation, which normally peak at sleep/wake transitions, peak instead at static times in SZ, suggesting suboptimal timing of these essential processes.https://doi.org/10.1371/journal.pbio.3001688 |
| spellingShingle | Madeline R Scott Wei Zong Kyle D Ketchesin Marianne L Seney George C Tseng Bokai Zhu Colleen A McClung Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia. PLoS Biology |
| title | Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia. |
| title_full | Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia. |
| title_fullStr | Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia. |
| title_full_unstemmed | Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia. |
| title_short | Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia. |
| title_sort | twelve hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia |
| url | https://doi.org/10.1371/journal.pbio.3001688 |
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