Temporal Progression of Aortic Valve Pathogenesis in a Mouse Model of Osteogenesis Imperfecta

Temporal Progression of Aortic Valve Pathogenesis in a Mouse Model of Osteogenesis Imperfecta

Organization of extracellular matrix (ECM) components, including collagens, proteoglycans, and elastin, is essential for maintaining the structure and function of heart valves throughout life. Mutations in ECM genes cause connective tissue disorders, including Osteogenesis Imperfecta (OI), and progr...

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Bibliographic Details
Main Authors: Kaitlyn Thatcher, Carol R. Mattern, Daniel Chaparro, Veronica Goveas, Michael R. McDermott, Jessica Fulton, Joshua D. Hutcheson, Brian R. Hoffmann, Joy Lincoln
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
aortic valve disease
extracellular matrix
connective tissue disorder
Online Access:https://www.mdpi.com/2308-3425/10/8/355

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