Novel, injection molded all-polyethylene composites for potential biomedical implant applications
This study aimed to create a self-reinforced composite material that can be processed by injection molding and other standard thermoplastic processing techniques and can be potentionally used as implant material. Self-reinforcement in biomaterials is desirable because it does not compromise biocompa...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Journal of Materials Research and Technology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2238785422000515 |
| _version_ | 1818772907675877376 |
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| author | László Mészáros Balázs Tatár Krisztina Toth Anna Földes Krisztina S. Nagy Angela Jedlovszky-Hajdu Tünde Tóth Kolos Molnár |
| author_facet | László Mészáros Balázs Tatár Krisztina Toth Anna Földes Krisztina S. Nagy Angela Jedlovszky-Hajdu Tünde Tóth Kolos Molnár |
| author_sort | László Mészáros |
| collection | DOAJ |
| description | This study aimed to create a self-reinforced composite material that can be processed by injection molding and other standard thermoplastic processing techniques and can be potentionally used as implant material. Self-reinforcement in biomaterials is desirable because it does not compromise biocompatibility and improves biofunctionality through improved mechanical performance. Self-reinforced composites can be currently processed by specialized, expensive and unproductive methods; hence we aimed to create a simpler processing alternative that works with biocompatible materials. We combined a high-density polyethylene matrix with high-performance polyethylene (Dyneema®) fibers. Before making the composite structure, the fibers were cross-linked by gamma irradiation to prevent their melting and maintain their structural integrity. The cross-linked fibers withstood the compounding by twin-screw extrusion and the subsequent injection molding. The effect of the irradiation dose on the processability, crystallinity, morphology, mechanical performance and cytotoxicity was investigated. We found that adding 20 m% of 200 kGy irradiated Dyneema® fibers increased the tensile modulus by 22.0%, the tensile strength by 71.1%, while both the composite and its constituents were all found to be biocompatible. The 41.1 MPa tensile strength, the 1.62 GPa tensile modulus, and the 64 Shore D hardness is quite similar to those of ultra-high molecular weight polyethylene, which is widely used in implants. Still, the material introduced in this paper shows no issues with the melt flow characteristics. These achievements are similar to other self-reinforcing methods, but the manufacturing method presented here can be economically realized on widely available processing technologies and machines. |
| first_indexed | 2024-12-18T10:16:49Z |
| format | Article |
| id | doaj.art-2d716ead066246a1bf18450fc56a8ba9 |
| institution | Directory Open Access Journal |
| issn | 2238-7854 |
| language | English |
| last_indexed | 2024-12-18T10:16:49Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Materials Research and Technology |
| spelling | doaj.art-2d716ead066246a1bf18450fc56a8ba92022-12-21T21:11:16ZengElsevierJournal of Materials Research and Technology2238-78542022-03-0117743755Novel, injection molded all-polyethylene composites for potential biomedical implant applicationsLászló Mészáros0Balázs Tatár1Krisztina Toth2Anna Földes3Krisztina S. Nagy4Angela Jedlovszky-Hajdu5Tünde Tóth6Kolos Molnár7Department of Polymer Engineering, Faculty of Mechanical Engineering, Budapest University of Technology and Economics, Műegyetem Rkp. 3, H-1111, Budapest, Hungary; MTA-BME Research Group for Composite Science and Technology, Műegyetem Rkp. 3, H-1111, Budapest, Hungary; Corresponding author.Department of Polymer Engineering, Faculty of Mechanical Engineering, Budapest University of Technology and Economics, Műegyetem Rkp. 3, H-1111, Budapest, HungaryLaboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, Nagyvárad Tér 4, H-1089, Budapest, HungaryDepartment of Oral Biology, Semmelweis University, Nagyvárad Tér 4, H-1089, Budapest, HungaryLaboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, Nagyvárad Tér 4, H-1089, Budapest, HungaryLaboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, Nagyvárad Tér 4, H-1089, Budapest, HungaryInstitute for Energy Security and Environmental Safety, Centre for Energy Research, Konkoly-Thege Miklós út 29-33, H-1121, Budapest, Hungary; Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Szent Gellért Tér 4, H-1111, Budapest, HungaryDepartment of Polymer Engineering, Faculty of Mechanical Engineering, Budapest University of Technology and Economics, Műegyetem Rkp. 3, H-1111, Budapest, Hungary; MTA-BME Research Group for Composite Science and Technology, Műegyetem Rkp. 3, H-1111, Budapest, HungaryThis study aimed to create a self-reinforced composite material that can be processed by injection molding and other standard thermoplastic processing techniques and can be potentionally used as implant material. Self-reinforcement in biomaterials is desirable because it does not compromise biocompatibility and improves biofunctionality through improved mechanical performance. Self-reinforced composites can be currently processed by specialized, expensive and unproductive methods; hence we aimed to create a simpler processing alternative that works with biocompatible materials. We combined a high-density polyethylene matrix with high-performance polyethylene (Dyneema®) fibers. Before making the composite structure, the fibers were cross-linked by gamma irradiation to prevent their melting and maintain their structural integrity. The cross-linked fibers withstood the compounding by twin-screw extrusion and the subsequent injection molding. The effect of the irradiation dose on the processability, crystallinity, morphology, mechanical performance and cytotoxicity was investigated. We found that adding 20 m% of 200 kGy irradiated Dyneema® fibers increased the tensile modulus by 22.0%, the tensile strength by 71.1%, while both the composite and its constituents were all found to be biocompatible. The 41.1 MPa tensile strength, the 1.62 GPa tensile modulus, and the 64 Shore D hardness is quite similar to those of ultra-high molecular weight polyethylene, which is widely used in implants. Still, the material introduced in this paper shows no issues with the melt flow characteristics. These achievements are similar to other self-reinforcing methods, but the manufacturing method presented here can be economically realized on widely available processing technologies and machines.http://www.sciencedirect.com/science/article/pii/S2238785422000515Self-reinforced compositeBiomaterialGamma irradiationInjection moldingCross-linked polyethylene |
| spellingShingle | László Mészáros Balázs Tatár Krisztina Toth Anna Földes Krisztina S. Nagy Angela Jedlovszky-Hajdu Tünde Tóth Kolos Molnár Novel, injection molded all-polyethylene composites for potential biomedical implant applications Journal of Materials Research and Technology Self-reinforced composite Biomaterial Gamma irradiation Injection molding Cross-linked polyethylene |
| title | Novel, injection molded all-polyethylene composites for potential biomedical implant applications |
| title_full | Novel, injection molded all-polyethylene composites for potential biomedical implant applications |
| title_fullStr | Novel, injection molded all-polyethylene composites for potential biomedical implant applications |
| title_full_unstemmed | Novel, injection molded all-polyethylene composites for potential biomedical implant applications |
| title_short | Novel, injection molded all-polyethylene composites for potential biomedical implant applications |
| title_sort | novel injection molded all polyethylene composites for potential biomedical implant applications |
| topic | Self-reinforced composite Biomaterial Gamma irradiation Injection molding Cross-linked polyethylene |
| url | http://www.sciencedirect.com/science/article/pii/S2238785422000515 |
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