Structural Basis for Unusual TCR CDR3β Usage Against an Immunodominant HIV-1 Gag Protein Peptide Restricted to an HLA-B*81:01 Molecule

Structural Basis for Unusual TCR CDR3β Usage Against an Immunodominant HIV-1 Gag Protein Peptide Restricted to an HLA-B*81:01 Molecule

In HIV infection, some closely associated human leukocyte antigen (HLA) alleles are correlated with distinct clinical outcomes although presenting the same HIV epitopes. The mechanism that underpins this observation is still unknown, but may be due to the essential features of HLA alleles or T cell...

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Bibliographic Details
Main Authors: Yang Liu, Jun Lei, Dan San, Yi Yang, Chonil Paek, Zixiong Xia, Yongshun Chen, Lei Yin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
HIV
T cell receptor
CD8+ T cells
HLA
antigen presentation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.822210/full

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