Retrospective Evaluation of New Chinese Diagnostic Scoring System for Disseminated Intravascular Coagulation.
<h4>Objectives</h4>To retrospectively validate the new Chinese DIC scoring system (CDSS).<h4>Methods</h4>This study retrospectively collected the information of 619 patients (371 cases with non-hematologic malignancies, 248 cases with hematologic malignancies) who suspected o...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0129170 |
| _version_ | 1818589473632419840 |
|---|---|
| author | Manzhi Wang Haiming Kou Jun Deng Huafang Wang Tao Guo Heng Mei Yu Hu |
| author_facet | Manzhi Wang Haiming Kou Jun Deng Huafang Wang Tao Guo Heng Mei Yu Hu |
| author_sort | Manzhi Wang |
| collection | DOAJ |
| description | <h4>Objectives</h4>To retrospectively validate the new Chinese DIC scoring system (CDSS).<h4>Methods</h4>This study retrospectively collected the information of 619 patients (371 cases with non-hematologic malignancies, 248 cases with hematologic malignancies) who suspected of DIC in Wuhan Union Hospital during 2013-4 to 2014-6. We validated CDSS by comparing it with three leading scoring systems, from International Society on Thrombosis and Haemostasis (ISTH), Japanese Association for Acute Medicine (JAAM) and Japanese Ministry of Health and Welfare (JMHW), and evaluated its prognostic value by 28 days mortality, APACHE II and SOFA score.<h4>Results</h4>In non-hematologic malignancies, CDSS was more specific than JAAM (72.55% vs. 50.49%, p<0.05) and more sensitive than ISTH (77.07% vs. 62.03%, p<0.05). In hematologic malignancies, the area under the ROC curve of CDSS was larger than ISTH and JMHW (0.933 vs. 0.889, p<0.01 with ISTH, 0.944 vs. 0.845, p<0.01 with JMHW). In addition, the 28-day mortality rate, SOFA scores, APACHE II scores of DIC patients diagnosed by CDSS were significantly greater than non-DIC (P <0.05).<h4>Conclusions</h4>We are the first group to propose CDSS. It emphasized the values of the clinical manifestations, the rapidly declining platelet count, APTT in the diagnosis of DIC and used D-dimer as the fibrin-related maker. DIC with hematological malignancies was treated as a special part. In this study we can see that CDSS displayed an acceptable property for the diagnosis of DIC with appropriate sensitivity and specificity, and also had a good prognostic value for DIC patients. |
| first_indexed | 2024-12-16T09:41:13Z |
| format | Article |
| id | doaj.art-2d74045b14924220ae1cffd01c879a24 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T09:41:13Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-2d74045b14924220ae1cffd01c879a242022-12-21T22:36:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01106e012917010.1371/journal.pone.0129170Retrospective Evaluation of New Chinese Diagnostic Scoring System for Disseminated Intravascular Coagulation.Manzhi WangHaiming KouJun DengHuafang WangTao GuoHeng MeiYu Hu<h4>Objectives</h4>To retrospectively validate the new Chinese DIC scoring system (CDSS).<h4>Methods</h4>This study retrospectively collected the information of 619 patients (371 cases with non-hematologic malignancies, 248 cases with hematologic malignancies) who suspected of DIC in Wuhan Union Hospital during 2013-4 to 2014-6. We validated CDSS by comparing it with three leading scoring systems, from International Society on Thrombosis and Haemostasis (ISTH), Japanese Association for Acute Medicine (JAAM) and Japanese Ministry of Health and Welfare (JMHW), and evaluated its prognostic value by 28 days mortality, APACHE II and SOFA score.<h4>Results</h4>In non-hematologic malignancies, CDSS was more specific than JAAM (72.55% vs. 50.49%, p<0.05) and more sensitive than ISTH (77.07% vs. 62.03%, p<0.05). In hematologic malignancies, the area under the ROC curve of CDSS was larger than ISTH and JMHW (0.933 vs. 0.889, p<0.01 with ISTH, 0.944 vs. 0.845, p<0.01 with JMHW). In addition, the 28-day mortality rate, SOFA scores, APACHE II scores of DIC patients diagnosed by CDSS were significantly greater than non-DIC (P <0.05).<h4>Conclusions</h4>We are the first group to propose CDSS. It emphasized the values of the clinical manifestations, the rapidly declining platelet count, APTT in the diagnosis of DIC and used D-dimer as the fibrin-related maker. DIC with hematological malignancies was treated as a special part. In this study we can see that CDSS displayed an acceptable property for the diagnosis of DIC with appropriate sensitivity and specificity, and also had a good prognostic value for DIC patients.https://doi.org/10.1371/journal.pone.0129170 |
| spellingShingle | Manzhi Wang Haiming Kou Jun Deng Huafang Wang Tao Guo Heng Mei Yu Hu Retrospective Evaluation of New Chinese Diagnostic Scoring System for Disseminated Intravascular Coagulation. PLoS ONE |
| title | Retrospective Evaluation of New Chinese Diagnostic Scoring System for Disseminated Intravascular Coagulation. |
| title_full | Retrospective Evaluation of New Chinese Diagnostic Scoring System for Disseminated Intravascular Coagulation. |
| title_fullStr | Retrospective Evaluation of New Chinese Diagnostic Scoring System for Disseminated Intravascular Coagulation. |
| title_full_unstemmed | Retrospective Evaluation of New Chinese Diagnostic Scoring System for Disseminated Intravascular Coagulation. |
| title_short | Retrospective Evaluation of New Chinese Diagnostic Scoring System for Disseminated Intravascular Coagulation. |
| title_sort | retrospective evaluation of new chinese diagnostic scoring system for disseminated intravascular coagulation |
| url | https://doi.org/10.1371/journal.pone.0129170 |
| work_keys_str_mv | AT manzhiwang retrospectiveevaluationofnewchinesediagnosticscoringsystemfordisseminatedintravascularcoagulation AT haimingkou retrospectiveevaluationofnewchinesediagnosticscoringsystemfordisseminatedintravascularcoagulation AT jundeng retrospectiveevaluationofnewchinesediagnosticscoringsystemfordisseminatedintravascularcoagulation AT huafangwang retrospectiveevaluationofnewchinesediagnosticscoringsystemfordisseminatedintravascularcoagulation AT taoguo retrospectiveevaluationofnewchinesediagnosticscoringsystemfordisseminatedintravascularcoagulation AT hengmei retrospectiveevaluationofnewchinesediagnosticscoringsystemfordisseminatedintravascularcoagulation AT yuhu retrospectiveevaluationofnewchinesediagnosticscoringsystemfordisseminatedintravascularcoagulation |