Transcriptomic and lipidomic profiling of subcutaneous and visceral adipose tissues in 15 vertebrates
Abstract The storage of lipids as energy in adipose tissue (AT) has been conserved over the course of evolution. However, substantial differences in ATs physiological activities were reported among species. Hence, establishing the mechanisms shaping evolutionarily divergence in ATs transcriptomes co...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-07-01
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| Series: | Scientific Data |
| Online Access: | https://doi.org/10.1038/s41597-023-02360-3 |
| _version_ | 1797779038389927936 |
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| author | Pengliang Liu Diyan Li Jiaman Zhang Mengnan He Yan Li Rui Liu Mingzhou Li |
| author_facet | Pengliang Liu Diyan Li Jiaman Zhang Mengnan He Yan Li Rui Liu Mingzhou Li |
| author_sort | Pengliang Liu |
| collection | DOAJ |
| description | Abstract The storage of lipids as energy in adipose tissue (AT) has been conserved over the course of evolution. However, substantial differences in ATs physiological activities were reported among species. Hence, establishing the mechanisms shaping evolutionarily divergence in ATs transcriptomes could provide a deeper understanding of AT regulation and its roles in obesity-related diseases. While previous studies performed anatomical, physiological and morphological comparisons between ATs across different species, little is currently understood at the molecular phenotypic levels. Here, we characterized transcriptional and lipidomic profiles of available subcutaneous and visceral ATs samples across 15 vertebrate species, spanning more than 300 million years of evolution, including placental mammals, birds and reptiles. We provide detailed descriptions of the datasets produced in this study and report gene expression and lipid profiles across samples. We demonstrate these data are robust and reveal the AT transcriptome and lipidome vary greater among species than within the same species. These datasets may serve as a resource for future studies on the functional differences among ATs in vertebrate species. |
| first_indexed | 2024-03-12T23:25:58Z |
| format | Article |
| id | doaj.art-2d74233091d84494ac110baa59a75a61 |
| institution | Directory Open Access Journal |
| issn | 2052-4463 |
| language | English |
| last_indexed | 2024-03-12T23:25:58Z |
| publishDate | 2023-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Data |
| spelling | doaj.art-2d74233091d84494ac110baa59a75a612023-07-16T11:09:12ZengNature PortfolioScientific Data2052-44632023-07-0110111010.1038/s41597-023-02360-3Transcriptomic and lipidomic profiling of subcutaneous and visceral adipose tissues in 15 vertebratesPengliang Liu0Diyan Li1Jiaman Zhang2Mengnan He3Yan Li4Rui Liu5Mingzhou Li6School of Pharmacy, Chengdu UniversitySchool of Pharmacy, Chengdu UniversityLivestock and Poultry Multi-omics Key Laboratory of Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural UniversityChengdu Research Base of Giant Panda BreedingChengdu Research Base of Giant Panda BreedingLivestock and Poultry Multi-omics Key Laboratory of Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural UniversityLivestock and Poultry Multi-omics Key Laboratory of Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural UniversityAbstract The storage of lipids as energy in adipose tissue (AT) has been conserved over the course of evolution. However, substantial differences in ATs physiological activities were reported among species. Hence, establishing the mechanisms shaping evolutionarily divergence in ATs transcriptomes could provide a deeper understanding of AT regulation and its roles in obesity-related diseases. While previous studies performed anatomical, physiological and morphological comparisons between ATs across different species, little is currently understood at the molecular phenotypic levels. Here, we characterized transcriptional and lipidomic profiles of available subcutaneous and visceral ATs samples across 15 vertebrate species, spanning more than 300 million years of evolution, including placental mammals, birds and reptiles. We provide detailed descriptions of the datasets produced in this study and report gene expression and lipid profiles across samples. We demonstrate these data are robust and reveal the AT transcriptome and lipidome vary greater among species than within the same species. These datasets may serve as a resource for future studies on the functional differences among ATs in vertebrate species.https://doi.org/10.1038/s41597-023-02360-3 |
| spellingShingle | Pengliang Liu Diyan Li Jiaman Zhang Mengnan He Yan Li Rui Liu Mingzhou Li Transcriptomic and lipidomic profiling of subcutaneous and visceral adipose tissues in 15 vertebrates Scientific Data |
| title | Transcriptomic and lipidomic profiling of subcutaneous and visceral adipose tissues in 15 vertebrates |
| title_full | Transcriptomic and lipidomic profiling of subcutaneous and visceral adipose tissues in 15 vertebrates |
| title_fullStr | Transcriptomic and lipidomic profiling of subcutaneous and visceral adipose tissues in 15 vertebrates |
| title_full_unstemmed | Transcriptomic and lipidomic profiling of subcutaneous and visceral adipose tissues in 15 vertebrates |
| title_short | Transcriptomic and lipidomic profiling of subcutaneous and visceral adipose tissues in 15 vertebrates |
| title_sort | transcriptomic and lipidomic profiling of subcutaneous and visceral adipose tissues in 15 vertebrates |
| url | https://doi.org/10.1038/s41597-023-02360-3 |
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