Indocyanine green fluorescence-navigated laparoscopic metastasectomy for peritoneal metastasis of hepatocellular carcinoma: a case report
Abstract Background Indocyanine green (ICG) can selectively accumulate in primary hepatocellular carcinoma (HCC) and its extrahepatic metastases. ICG fluorescence imaging is an extremely sensitive intraoperative tool for detecting HCC foci and can be used to detect impalpable tumors in laparoscopic...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2018-11-01
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| Series: | Surgical Case Reports |
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| Online Access: | http://link.springer.com/article/10.1186/s40792-018-0537-x |
| _version_ | 1818602132614414336 |
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| author | Yoshihiro Miyazaki Masanao Kurata Yukio Oshiro Osamu Shimomura Kazuhiro Takahashi Tatsuya Oda Nobuhiro Ohkohchi |
| author_facet | Yoshihiro Miyazaki Masanao Kurata Yukio Oshiro Osamu Shimomura Kazuhiro Takahashi Tatsuya Oda Nobuhiro Ohkohchi |
| author_sort | Yoshihiro Miyazaki |
| collection | DOAJ |
| description | Abstract Background Indocyanine green (ICG) can selectively accumulate in primary hepatocellular carcinoma (HCC) and its extrahepatic metastases. ICG fluorescence imaging is an extremely sensitive intraoperative tool for detecting HCC foci and can be used to detect impalpable tumors in laparoscopic surgery. Here, we report a case of a 75-year-old man who underwent peritoneal metastasis resection of HCC using a laparoscopic near-infrared imaging system and ICG fluorescence-navigated surgery. Case presentation A 75-year-old man was referred to our department for peritoneal metastasis resection of HCC. Two years before admission, he had undergone transarterial embolization and segmentectomy of segment 6 with open surgery for ruptured HCC. Computed tomography revealed a 12-mm peritoneal metastatic lesion on the abdominal wall near the cut surface of the liver. No other metastases were observed; resection of the solitary metastasis was scheduled. ICG (0.5 mg/kg body weight) was intravenously injected, 72 h preoperatively. An endoscopic, ICG near-infrared fluorescence imaging system revealed clear green fluorescence, indicating peritoneal metastasis of HCC on the abdominal wall. The tumor was resected with adequate surgical margin by partially resecting the liver and diaphragm, followed by histological confirmation as peritoneal metastasis of HCC. No recurrence was observed after 12 months of follow-up. Conclusions ICG fluorescence can be useful in laparoscopic surgery for identifying peritoneal metastasis. |
| first_indexed | 2024-12-16T13:02:25Z |
| format | Article |
| id | doaj.art-2d742c59f9d74983b18a8a13aa8a9427 |
| institution | Directory Open Access Journal |
| issn | 2198-7793 |
| language | English |
| last_indexed | 2024-12-16T13:02:25Z |
| publishDate | 2018-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj.art-2d742c59f9d74983b18a8a13aa8a94272022-12-21T22:30:47ZengSpringerOpenSurgical Case Reports2198-77932018-11-01411410.1186/s40792-018-0537-xIndocyanine green fluorescence-navigated laparoscopic metastasectomy for peritoneal metastasis of hepatocellular carcinoma: a case reportYoshihiro Miyazaki0Masanao Kurata1Yukio Oshiro2Osamu Shimomura3Kazuhiro Takahashi4Tatsuya Oda5Nobuhiro Ohkohchi6Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of TsukubaDepartment of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of TsukubaDepartment of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of TsukubaDepartment of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of TsukubaDepartment of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of TsukubaDepartment of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of TsukubaDepartment of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of TsukubaAbstract Background Indocyanine green (ICG) can selectively accumulate in primary hepatocellular carcinoma (HCC) and its extrahepatic metastases. ICG fluorescence imaging is an extremely sensitive intraoperative tool for detecting HCC foci and can be used to detect impalpable tumors in laparoscopic surgery. Here, we report a case of a 75-year-old man who underwent peritoneal metastasis resection of HCC using a laparoscopic near-infrared imaging system and ICG fluorescence-navigated surgery. Case presentation A 75-year-old man was referred to our department for peritoneal metastasis resection of HCC. Two years before admission, he had undergone transarterial embolization and segmentectomy of segment 6 with open surgery for ruptured HCC. Computed tomography revealed a 12-mm peritoneal metastatic lesion on the abdominal wall near the cut surface of the liver. No other metastases were observed; resection of the solitary metastasis was scheduled. ICG (0.5 mg/kg body weight) was intravenously injected, 72 h preoperatively. An endoscopic, ICG near-infrared fluorescence imaging system revealed clear green fluorescence, indicating peritoneal metastasis of HCC on the abdominal wall. The tumor was resected with adequate surgical margin by partially resecting the liver and diaphragm, followed by histological confirmation as peritoneal metastasis of HCC. No recurrence was observed after 12 months of follow-up. Conclusions ICG fluorescence can be useful in laparoscopic surgery for identifying peritoneal metastasis.http://link.springer.com/article/10.1186/s40792-018-0537-xFluorescenceHepatocellular carcinomaIndocyanine greenMetastasis |
| spellingShingle | Yoshihiro Miyazaki Masanao Kurata Yukio Oshiro Osamu Shimomura Kazuhiro Takahashi Tatsuya Oda Nobuhiro Ohkohchi Indocyanine green fluorescence-navigated laparoscopic metastasectomy for peritoneal metastasis of hepatocellular carcinoma: a case report Surgical Case Reports Fluorescence Hepatocellular carcinoma Indocyanine green Metastasis |
| title | Indocyanine green fluorescence-navigated laparoscopic metastasectomy for peritoneal metastasis of hepatocellular carcinoma: a case report |
| title_full | Indocyanine green fluorescence-navigated laparoscopic metastasectomy for peritoneal metastasis of hepatocellular carcinoma: a case report |
| title_fullStr | Indocyanine green fluorescence-navigated laparoscopic metastasectomy for peritoneal metastasis of hepatocellular carcinoma: a case report |
| title_full_unstemmed | Indocyanine green fluorescence-navigated laparoscopic metastasectomy for peritoneal metastasis of hepatocellular carcinoma: a case report |
| title_short | Indocyanine green fluorescence-navigated laparoscopic metastasectomy for peritoneal metastasis of hepatocellular carcinoma: a case report |
| title_sort | indocyanine green fluorescence navigated laparoscopic metastasectomy for peritoneal metastasis of hepatocellular carcinoma a case report |
| topic | Fluorescence Hepatocellular carcinoma Indocyanine green Metastasis |
| url | http://link.springer.com/article/10.1186/s40792-018-0537-x |
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