The role and therapeutic potential of nuclear factor κB (NF-κB) in ischemic stroke
Stroke is a prevalent cerebrovascular condition with a global impact, causing significant rates of illness and death. Despite extensive research, the available treatment options for stroke remain restricted. Hence, it is crucial to gain a deeper understanding of the molecular mechanisms associated w...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332224000210 |
| _version_ | 1797324320834322432 |
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| author | Guangyu Xu Fang Dong Lei Su Zi-Xuan Tan Mingcheng Lei Lina Li Di Wen Feng Zhang |
| author_facet | Guangyu Xu Fang Dong Lei Su Zi-Xuan Tan Mingcheng Lei Lina Li Di Wen Feng Zhang |
| author_sort | Guangyu Xu |
| collection | DOAJ |
| description | Stroke is a prevalent cerebrovascular condition with a global impact, causing significant rates of illness and death. Despite extensive research, the available treatment options for stroke remain restricted. Hence, it is crucial to gain a deeper understanding of the molecular mechanisms associated with the onset and advancement of stroke in order to establish a theoretical foundation for novel preventive and therapeutic approaches. NF-κB, also known as nuclear factor κB, is a transcription factor responsible for controlling the expression of numerous genes and plays a crucial role in diverse physiological processes. NF-κB is triggered and regulates neuroinflammation and other processes after stroke, promoting the generation of cytokine storms and contributing to the advancement of ischemic stroke (IS). Therefore, NF-κB could potentially play a vital role in stroke by regulating diverse pathophysiological processes. This review provides an overview of the functions of NF-κB in stroke and its governing mechanisms. In addition, our attention is directed towards various potential therapies that aim to inhibit the NF-κB signaling pathway in order to offer valuable insights for the advancement of innovative treatment approaches for stroke. |
| first_indexed | 2024-03-08T05:55:25Z |
| format | Article |
| id | doaj.art-2d74a04a76b54c63b52e06a80f40173c |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-08T05:55:25Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-2d74a04a76b54c63b52e06a80f40173c2024-02-05T04:31:15ZengElsevierBiomedicine & Pharmacotherapy0753-33222024-02-01171116140The role and therapeutic potential of nuclear factor κB (NF-κB) in ischemic strokeGuangyu Xu0Fang Dong1Lei Su2Zi-Xuan Tan3Mingcheng Lei4Lina Li5Di Wen6Feng Zhang7Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR ChinaDepartment of Clinical Laboratory Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR ChinaDepartment of Radiotherapy, Affiliated Hospital of Hebei University, Baoding 071000, PR ChinaDepartment of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR ChinaDepartment of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR ChinaDepartment of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR ChinaCollege of Forensic Medicine, Hebei Medical University, Shijiazhuang 050017, PR China; Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Shijiazhuang 050017, PR China; Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang 050017, PR China; Correspondence to: Department of Forensic Medicine, Hebei Medical University, No. 361 East Zhongshan Road, 050017 Shijiazhuang, PR China.Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR China; Correspondence to: Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, No. 139 Ziqiang Road, 050051 Shijiazhuang, Hebei, PR China.Stroke is a prevalent cerebrovascular condition with a global impact, causing significant rates of illness and death. Despite extensive research, the available treatment options for stroke remain restricted. Hence, it is crucial to gain a deeper understanding of the molecular mechanisms associated with the onset and advancement of stroke in order to establish a theoretical foundation for novel preventive and therapeutic approaches. NF-κB, also known as nuclear factor κB, is a transcription factor responsible for controlling the expression of numerous genes and plays a crucial role in diverse physiological processes. NF-κB is triggered and regulates neuroinflammation and other processes after stroke, promoting the generation of cytokine storms and contributing to the advancement of ischemic stroke (IS). Therefore, NF-κB could potentially play a vital role in stroke by regulating diverse pathophysiological processes. This review provides an overview of the functions of NF-κB in stroke and its governing mechanisms. In addition, our attention is directed towards various potential therapies that aim to inhibit the NF-κB signaling pathway in order to offer valuable insights for the advancement of innovative treatment approaches for stroke.http://www.sciencedirect.com/science/article/pii/S0753332224000210Nuclear factor κBIschemic strokeNeuroinflammationBlood-brain-barrier |
| spellingShingle | Guangyu Xu Fang Dong Lei Su Zi-Xuan Tan Mingcheng Lei Lina Li Di Wen Feng Zhang The role and therapeutic potential of nuclear factor κB (NF-κB) in ischemic stroke Biomedicine & Pharmacotherapy Nuclear factor κB Ischemic stroke Neuroinflammation Blood-brain-barrier |
| title | The role and therapeutic potential of nuclear factor κB (NF-κB) in ischemic stroke |
| title_full | The role and therapeutic potential of nuclear factor κB (NF-κB) in ischemic stroke |
| title_fullStr | The role and therapeutic potential of nuclear factor κB (NF-κB) in ischemic stroke |
| title_full_unstemmed | The role and therapeutic potential of nuclear factor κB (NF-κB) in ischemic stroke |
| title_short | The role and therapeutic potential of nuclear factor κB (NF-κB) in ischemic stroke |
| title_sort | role and therapeutic potential of nuclear factor κb nf κb in ischemic stroke |
| topic | Nuclear factor κB Ischemic stroke Neuroinflammation Blood-brain-barrier |
| url | http://www.sciencedirect.com/science/article/pii/S0753332224000210 |
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