Twists in the fibrodysplasia ossificans progressiva story challenge and expand our understanding of BMP biology
Fibrodysplasia ossificans progressiva (FOP) is an ultrarare, debilitating disease in which heterotopic bone is formed in certain soft tissues. A gain-of-function variant in the cytoplasmic domain of the activin A receptor type I (ACVR1) exists in all patients with FOP. Strikingly, these FOP-causing...
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| Format: | Article |
| Language: | English |
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American Society for Clinical Investigation
2022-06-01
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| Series: | The Journal of Clinical Investigation |
| Online Access: | https://doi.org/10.1172/JCI160773 |