Alarmin Cytokines as Central Regulators of Cutaneous Immunity
Skin acts as the primary interface between the body and the environment. The skin immune system is composed of a complex network of immune cells and factors that provide the first line of defense against microbial pathogens and environmental insults. Alarmin cytokines mediate an intricate intercellu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.876515/full |
| _version_ | 1818286656080314368 |
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| author | Tatsuya Hasegawa Tomonori Oka Shadmehr Demehri |
| author_facet | Tatsuya Hasegawa Tomonori Oka Shadmehr Demehri |
| author_sort | Tatsuya Hasegawa |
| collection | DOAJ |
| description | Skin acts as the primary interface between the body and the environment. The skin immune system is composed of a complex network of immune cells and factors that provide the first line of defense against microbial pathogens and environmental insults. Alarmin cytokines mediate an intricate intercellular communication between keratinocytes and immune cells to regulate cutaneous immune responses. Proper functions of the type 2 alarmin cytokines, thymic stromal lymphopoietin (TSLP), interleukin (IL)-25, and IL-33, are paramount to the maintenance of skin homeostasis, and their dysregulation is commonly associated with allergic inflammation. In this review, we discuss recent findings on the complex regulatory network of type 2 alarmin cytokines that control skin immunity and highlight the mechanisms by which these cytokines regulate skin immune responses in host defense, chronic inflammation, and cancer. |
| first_indexed | 2024-12-13T01:28:03Z |
| format | Article |
| id | doaj.art-2d779832846841e0981a006ebe2a4dab |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T01:28:03Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-2d779832846841e0981a006ebe2a4dab2022-12-22T00:04:04ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-03-011310.3389/fimmu.2022.876515876515Alarmin Cytokines as Central Regulators of Cutaneous ImmunityTatsuya Hasegawa0Tomonori Oka1Shadmehr Demehri2Shiseido Global Innovation Center, Yokohama, JapanCenter for Cancer Immunology and Cutaneous Biology Research Center, Department of Dermatology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United StatesCenter for Cancer Immunology and Cutaneous Biology Research Center, Department of Dermatology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United StatesSkin acts as the primary interface between the body and the environment. The skin immune system is composed of a complex network of immune cells and factors that provide the first line of defense against microbial pathogens and environmental insults. Alarmin cytokines mediate an intricate intercellular communication between keratinocytes and immune cells to regulate cutaneous immune responses. Proper functions of the type 2 alarmin cytokines, thymic stromal lymphopoietin (TSLP), interleukin (IL)-25, and IL-33, are paramount to the maintenance of skin homeostasis, and their dysregulation is commonly associated with allergic inflammation. In this review, we discuss recent findings on the complex regulatory network of type 2 alarmin cytokines that control skin immunity and highlight the mechanisms by which these cytokines regulate skin immune responses in host defense, chronic inflammation, and cancer.https://www.frontiersin.org/articles/10.3389/fimmu.2022.876515/fullTSLPIL-33IL-25skin immunlogyallergic inflammationcancer |
| spellingShingle | Tatsuya Hasegawa Tomonori Oka Shadmehr Demehri Alarmin Cytokines as Central Regulators of Cutaneous Immunity Frontiers in Immunology TSLP IL-33 IL-25 skin immunlogy allergic inflammation cancer |
| title | Alarmin Cytokines as Central Regulators of Cutaneous Immunity |
| title_full | Alarmin Cytokines as Central Regulators of Cutaneous Immunity |
| title_fullStr | Alarmin Cytokines as Central Regulators of Cutaneous Immunity |
| title_full_unstemmed | Alarmin Cytokines as Central Regulators of Cutaneous Immunity |
| title_short | Alarmin Cytokines as Central Regulators of Cutaneous Immunity |
| title_sort | alarmin cytokines as central regulators of cutaneous immunity |
| topic | TSLP IL-33 IL-25 skin immunlogy allergic inflammation cancer |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.876515/full |
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