Pharmacoinformatics and Preclinical Studies of NSC765690 and NSC765599, Potential STAT3/CDK2/4/6 Inhibitors with Antitumor Activities against NCI60 Human Tumor Cell Lines
Signal transducer and activator of transcription 3 (STAT3) is a transcriptional regulator of a number of biological processes including cell differentiation, proliferation, survival, and angiogenesis, while cyclin-dependent kinases (CDKs) are a critical regulator of cell cycle progression. These pro...
Main Authors: | Bashir Lawal, Yen-Lin Liu, Ntlotlang Mokgautsi, Harshita Khedkar, Maryam Rachmawati Sumitra, Alexander T. H. Wu, Hsu-Shan Huang |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-01-01
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Series: | Biomedicines |
Subjects: | |
Online Access: | https://www.mdpi.com/2227-9059/9/1/92 |
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