Immunohistological Analysis of Lichen Sclerosus of the Foreskin in Pediatric Age: Could It Be Considered a Premalignant Lesion?

Immunohistological Analysis of Lichen Sclerosus of the Foreskin in Pediatric Age: Could It Be Considered a Premalignant Lesion?

Background: A major worry of juvenile penile LS is potential malignant degeneration to spinocellular carcinoma (SCC) in adulthood. LS is characterized by increased CD8+ and CD57+ cells, dermal sclerosis, epidermal atrophy, and hyperkeratosis. p53 and Ki67 are reliable premalignant markers. Our aim w...

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Bibliographic Details
Main Authors: Salvatore Arena, Antonio Ieni, Monica Currò, Mario Vaccaro, Donatella Di Fabrizio, Fabiola Cassaro, Roberta Bonfiglio, Angela Simona Montalto, Giovanni Tuccari, Angela Alibrandi, Pietro Impellizzeri, Carmelo Romeo
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Biomedicines
Subjects:
lichen sclerosus
foreskin
spinocellular carcinoma
children
immunohistology
Online Access:https://www.mdpi.com/2227-9059/11/7/1986

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