Retinal nerve fiber layer thickness in normal Indian pediatric population measured with optical coherence tomography
Purpose: To measure the peripapillary retinal nerve fiber layer (RNFL) thickness in normal Indian pediatric population. Subjects and Methods: 120 normal Indian children ages 5-17 years presenting to the Pediatric Clinic were included in this observational cross-sectional study. RNFL thickness was me...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Indian Journal of Ophthalmology |
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| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2014;volume=62;issue=4;spage=412;epage=418;aulast=Pawar |
| _version_ | 1818365559271587840 |
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| author | Neelam Pawar Devendra Maheshwari Meenakshi Ravindran Renagappa Ramakrishnan |
| author_facet | Neelam Pawar Devendra Maheshwari Meenakshi Ravindran Renagappa Ramakrishnan |
| author_sort | Neelam Pawar |
| collection | DOAJ |
| description | Purpose: To measure the peripapillary retinal nerve fiber layer (RNFL) thickness in normal Indian pediatric population. Subjects and Methods: 120 normal Indian children ages 5-17 years presenting to the Pediatric Clinic were included in this observational cross-sectional study. RNFL thickness was measured with stratus optical coherence tomography (OCT). Children with strabismus or amblyopia, with neurological, metabolic, vascular, or other disorders and those with abnormal optic discs were excluded. One eye of each subject was randomly selected for statistical analysis. The effect of age, refraction and gender on RNFL thickness was investigated statistically. Result: OCT measurements were obtained in 120 of 130 (92.3%) subjects. Mean age was 10.8 ± 3.24 years (range 5-17). Average RNFL thickness was (± SD) 106.11 ± 9.5 μm (range 82.26-146.25). The RNFL was thickest inferiorly (134.10 ± 16.16 μm) and superiorly (133.44 ± 15.50 μm), thinner nasally (84.26 ± 16.43 μm), and thinnest temporally (70.72 ± 14.80 μm). In univariate regression analysis, age had no statistical significant effect on RNFL thickness (P = 0.7249) and refraction had a significant effect on RNFL thickness (P = 0.0008). Conclusion: OCT can be used to measure RNFL thickness in children. Refraction had an effect on RNFL thickness. In normal children, variation in RNFL thickness is large. The normative data provided by this study may assist in identifying changes in RNFL thickness in Indian children. |
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| format | Article |
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| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-12-13T22:22:11Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-2d793f73371e40dd9ff78c182366c3232022-12-21T23:29:20ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892014-01-0162441241810.4103/0301-4738.121185Retinal nerve fiber layer thickness in normal Indian pediatric population measured with optical coherence tomographyNeelam PawarDevendra MaheshwariMeenakshi RavindranRenagappa RamakrishnanPurpose: To measure the peripapillary retinal nerve fiber layer (RNFL) thickness in normal Indian pediatric population. Subjects and Methods: 120 normal Indian children ages 5-17 years presenting to the Pediatric Clinic were included in this observational cross-sectional study. RNFL thickness was measured with stratus optical coherence tomography (OCT). Children with strabismus or amblyopia, with neurological, metabolic, vascular, or other disorders and those with abnormal optic discs were excluded. One eye of each subject was randomly selected for statistical analysis. The effect of age, refraction and gender on RNFL thickness was investigated statistically. Result: OCT measurements were obtained in 120 of 130 (92.3%) subjects. Mean age was 10.8 ± 3.24 years (range 5-17). Average RNFL thickness was (± SD) 106.11 ± 9.5 μm (range 82.26-146.25). The RNFL was thickest inferiorly (134.10 ± 16.16 μm) and superiorly (133.44 ± 15.50 μm), thinner nasally (84.26 ± 16.43 μm), and thinnest temporally (70.72 ± 14.80 μm). In univariate regression analysis, age had no statistical significant effect on RNFL thickness (P = 0.7249) and refraction had a significant effect on RNFL thickness (P = 0.0008). Conclusion: OCT can be used to measure RNFL thickness in children. Refraction had an effect on RNFL thickness. In normal children, variation in RNFL thickness is large. The normative data provided by this study may assist in identifying changes in RNFL thickness in Indian children.http://www.ijo.in/article.asp?issn=0301-4738;year=2014;volume=62;issue=4;spage=412;epage=418;aulast=PawarMean deviationnon-proliferative diabetic retinopathyshort fluctuationsshort wave automated perimetrystandard automated perimetryAntimicrobial effectconventional silicone oilendophthalmitis agentsheavy silicone oilKeratoconusmodified deep anterior lamellar keratoplastysteep corneal curvatureBevacizumabbranch retinal vein occlusionintravitrealmacular edematriamcinoloneBlindnessdisability evaluationquality of lifevisual acuityMitomycin Cpterygium recurrencepterygium surgerysubconjunctival bevacizumab injectionImaging in glaucomaoptical coherence tomographypediatricretinal nerve fiber layer |
| spellingShingle | Neelam Pawar Devendra Maheshwari Meenakshi Ravindran Renagappa Ramakrishnan Retinal nerve fiber layer thickness in normal Indian pediatric population measured with optical coherence tomography Indian Journal of Ophthalmology Mean deviation non-proliferative diabetic retinopathy short fluctuations short wave automated perimetry standard automated perimetry Antimicrobial effect conventional silicone oil endophthalmitis agents heavy silicone oil Keratoconus modified deep anterior lamellar keratoplasty steep corneal curvature Bevacizumab branch retinal vein occlusion intravitreal macular edema triamcinolone Blindness disability evaluation quality of life visual acuity Mitomycin C pterygium recurrence pterygium surgery subconjunctival bevacizumab injection Imaging in glaucoma optical coherence tomography pediatric retinal nerve fiber layer |
| title | Retinal nerve fiber layer thickness in normal Indian pediatric population measured with optical coherence tomography |
| title_full | Retinal nerve fiber layer thickness in normal Indian pediatric population measured with optical coherence tomography |
| title_fullStr | Retinal nerve fiber layer thickness in normal Indian pediatric population measured with optical coherence tomography |
| title_full_unstemmed | Retinal nerve fiber layer thickness in normal Indian pediatric population measured with optical coherence tomography |
| title_short | Retinal nerve fiber layer thickness in normal Indian pediatric population measured with optical coherence tomography |
| title_sort | retinal nerve fiber layer thickness in normal indian pediatric population measured with optical coherence tomography |
| topic | Mean deviation non-proliferative diabetic retinopathy short fluctuations short wave automated perimetry standard automated perimetry Antimicrobial effect conventional silicone oil endophthalmitis agents heavy silicone oil Keratoconus modified deep anterior lamellar keratoplasty steep corneal curvature Bevacizumab branch retinal vein occlusion intravitreal macular edema triamcinolone Blindness disability evaluation quality of life visual acuity Mitomycin C pterygium recurrence pterygium surgery subconjunctival bevacizumab injection Imaging in glaucoma optical coherence tomography pediatric retinal nerve fiber layer |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2014;volume=62;issue=4;spage=412;epage=418;aulast=Pawar |
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