HLA-DQ2 and -DQ8 genotype frequency in Syrian celiac disease children: HLA-DQ relative risks evaluation
Abstract Background Celiac disease (CD) is a common autoimmune disease in Syria which manifesting with inflammation of the small intestine and with various extra intestinal symptoms. The disease is associated with human HLA-DQ genes encoding HLA-DQ2 and DQ8 proteins. Methods In this study, 49 childr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-05-01
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| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12876-018-0802-2 |
| _version_ | 1818609999475113984 |
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| author | Hossam Murad Batoul Jazairi Issam Khansaa Doaa Olabi Lina Khouri |
| author_facet | Hossam Murad Batoul Jazairi Issam Khansaa Doaa Olabi Lina Khouri |
| author_sort | Hossam Murad |
| collection | DOAJ |
| description | Abstract Background Celiac disease (CD) is a common autoimmune disease in Syria which manifesting with inflammation of the small intestine and with various extra intestinal symptoms. The disease is associated with human HLA-DQ genes encoding HLA-DQ2 and DQ8 proteins. Methods In this study, 49 children patients of CD and 58 healthy control samples were genotyped for HLA-DQ genes using SSP-PCR technique. Relative risks for different genotypes were also evaluated. Results The DQB1*0201 allele was the most common in the patients (77.6%) followed by DQB1*0302 allele (10.2%). The highest HLA-DQB risk for CD development was found in patients carriers a DQ2.5/DQ8 genotype (1/10), followed by the patients carriers DQ2.5/DQ2.5 (1/12). Conclusion The significant differences in the frequency of HLA-DQ2 and HLA-DQ8 in Syrian patients in compared with controls and relative risks predicted demonstrated the importance role of these alleles in the development of CD in Syrian children patients. |
| first_indexed | 2024-12-16T15:07:28Z |
| format | Article |
| id | doaj.art-2d7afcf873c140b1a4ac0e547c293e80 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-16T15:07:28Z |
| publishDate | 2018-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-2d7afcf873c140b1a4ac0e547c293e802022-12-21T22:27:04ZengBMCBMC Gastroenterology1471-230X2018-05-011811410.1186/s12876-018-0802-2HLA-DQ2 and -DQ8 genotype frequency in Syrian celiac disease children: HLA-DQ relative risks evaluationHossam Murad0Batoul Jazairi1Issam Khansaa2Doaa Olabi3Lina Khouri4Molecular Biology and Biotechnology Department, Human Genetics Division, Atomic Energy Commission of SyriaMolecular Biology and Biotechnology Department, Human Genetics Division, Atomic Energy Commission of SyriaMolecular Biology and Biotechnology Department, Human Genetics Division, Atomic Energy Commission of SyriaChildren’s hospitalChildren’s hospitalAbstract Background Celiac disease (CD) is a common autoimmune disease in Syria which manifesting with inflammation of the small intestine and with various extra intestinal symptoms. The disease is associated with human HLA-DQ genes encoding HLA-DQ2 and DQ8 proteins. Methods In this study, 49 children patients of CD and 58 healthy control samples were genotyped for HLA-DQ genes using SSP-PCR technique. Relative risks for different genotypes were also evaluated. Results The DQB1*0201 allele was the most common in the patients (77.6%) followed by DQB1*0302 allele (10.2%). The highest HLA-DQB risk for CD development was found in patients carriers a DQ2.5/DQ8 genotype (1/10), followed by the patients carriers DQ2.5/DQ2.5 (1/12). Conclusion The significant differences in the frequency of HLA-DQ2 and HLA-DQ8 in Syrian patients in compared with controls and relative risks predicted demonstrated the importance role of these alleles in the development of CD in Syrian children patients.http://link.springer.com/article/10.1186/s12876-018-0802-2Celiac diseaseHLAChildrenSyria |
| spellingShingle | Hossam Murad Batoul Jazairi Issam Khansaa Doaa Olabi Lina Khouri HLA-DQ2 and -DQ8 genotype frequency in Syrian celiac disease children: HLA-DQ relative risks evaluation BMC Gastroenterology Celiac disease HLA Children Syria |
| title | HLA-DQ2 and -DQ8 genotype frequency in Syrian celiac disease children: HLA-DQ relative risks evaluation |
| title_full | HLA-DQ2 and -DQ8 genotype frequency in Syrian celiac disease children: HLA-DQ relative risks evaluation |
| title_fullStr | HLA-DQ2 and -DQ8 genotype frequency in Syrian celiac disease children: HLA-DQ relative risks evaluation |
| title_full_unstemmed | HLA-DQ2 and -DQ8 genotype frequency in Syrian celiac disease children: HLA-DQ relative risks evaluation |
| title_short | HLA-DQ2 and -DQ8 genotype frequency in Syrian celiac disease children: HLA-DQ relative risks evaluation |
| title_sort | hla dq2 and dq8 genotype frequency in syrian celiac disease children hla dq relative risks evaluation |
| topic | Celiac disease HLA Children Syria |
| url | http://link.springer.com/article/10.1186/s12876-018-0802-2 |
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