Epithelial-to-Mesenchymal Transition in Metastasis: Focus on Laryngeal Carcinoma
In epithelial neoplasms, such as laryngeal carcinoma, the survival indexes deteriorate abruptly when the tumor becomes metastatic. A molecular phenomenon that normally appears during embryogenesis, epithelial-to-mesenchymal transition (EMT), is reactivated at the initial stage of metastasis when tum...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/9/2148 |
| _version_ | 1797490856267087872 |
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| author | Anastasios Goulioumis Kostis Gyftopoulos |
| author_facet | Anastasios Goulioumis Kostis Gyftopoulos |
| author_sort | Anastasios Goulioumis |
| collection | DOAJ |
| description | In epithelial neoplasms, such as laryngeal carcinoma, the survival indexes deteriorate abruptly when the tumor becomes metastatic. A molecular phenomenon that normally appears during embryogenesis, epithelial-to-mesenchymal transition (EMT), is reactivated at the initial stage of metastasis when tumor cells invade the adjacent stroma. The hallmarks of this phenomenon are the abolishment of the epithelial and acquisition of mesenchymal traits by tumor cells which enhance their migratory capacity. EMT signaling is mediated by complex molecular pathways that regulate the expression of crucial molecules contributing to the tumor’s metastatic potential. Effectors of EMT include loss of adhesion, cytoskeleton remodeling, evasion of apoptosis and immune surveillance, upregulation of metalloproteinases, neovascularization, acquisition of stem-cell properties, and the activation of tumor stroma. However, the current approach to EMT involves a holistic model that incorporates the acquisition of potentials beyond mesenchymal transition. As EMT is inevitably associated with a reverse mesenchymal-to-epithelial transition (MET), a model of partial EMT is currently accepted, signifying the cell plasticity associated with invasion and metastasis. In this review, we identify the cumulative evidence which suggests that various aspects of EMT theory apply to laryngeal carcinoma, a tumor of significant morbidity and mortality, introducing novel molecular targets with prognostic and therapeutic potential. |
| first_indexed | 2024-03-10T00:39:02Z |
| format | Article |
| id | doaj.art-2d7b3a47d3c74c5585d5b51029511e46 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T00:39:02Z |
| publishDate | 2022-09-01 |
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| series | Biomedicines |
| spelling | doaj.art-2d7b3a47d3c74c5585d5b51029511e462023-11-23T15:09:56ZengMDPI AGBiomedicines2227-90592022-09-01109214810.3390/biomedicines10092148Epithelial-to-Mesenchymal Transition in Metastasis: Focus on Laryngeal CarcinomaAnastasios Goulioumis0Kostis Gyftopoulos1Department of Anatomy, University of Patras School of Medicine, 26504 Patras, GreeceDepartment of Anatomy, University of Patras School of Medicine, 26504 Patras, GreeceIn epithelial neoplasms, such as laryngeal carcinoma, the survival indexes deteriorate abruptly when the tumor becomes metastatic. A molecular phenomenon that normally appears during embryogenesis, epithelial-to-mesenchymal transition (EMT), is reactivated at the initial stage of metastasis when tumor cells invade the adjacent stroma. The hallmarks of this phenomenon are the abolishment of the epithelial and acquisition of mesenchymal traits by tumor cells which enhance their migratory capacity. EMT signaling is mediated by complex molecular pathways that regulate the expression of crucial molecules contributing to the tumor’s metastatic potential. Effectors of EMT include loss of adhesion, cytoskeleton remodeling, evasion of apoptosis and immune surveillance, upregulation of metalloproteinases, neovascularization, acquisition of stem-cell properties, and the activation of tumor stroma. However, the current approach to EMT involves a holistic model that incorporates the acquisition of potentials beyond mesenchymal transition. As EMT is inevitably associated with a reverse mesenchymal-to-epithelial transition (MET), a model of partial EMT is currently accepted, signifying the cell plasticity associated with invasion and metastasis. In this review, we identify the cumulative evidence which suggests that various aspects of EMT theory apply to laryngeal carcinoma, a tumor of significant morbidity and mortality, introducing novel molecular targets with prognostic and therapeutic potential.https://www.mdpi.com/2227-9059/10/9/2148epithelial to mesenchymal transition (EMT)laryngeal carcinomametastasis |
| spellingShingle | Anastasios Goulioumis Kostis Gyftopoulos Epithelial-to-Mesenchymal Transition in Metastasis: Focus on Laryngeal Carcinoma Biomedicines epithelial to mesenchymal transition (EMT) laryngeal carcinoma metastasis |
| title | Epithelial-to-Mesenchymal Transition in Metastasis: Focus on Laryngeal Carcinoma |
| title_full | Epithelial-to-Mesenchymal Transition in Metastasis: Focus on Laryngeal Carcinoma |
| title_fullStr | Epithelial-to-Mesenchymal Transition in Metastasis: Focus on Laryngeal Carcinoma |
| title_full_unstemmed | Epithelial-to-Mesenchymal Transition in Metastasis: Focus on Laryngeal Carcinoma |
| title_short | Epithelial-to-Mesenchymal Transition in Metastasis: Focus on Laryngeal Carcinoma |
| title_sort | epithelial to mesenchymal transition in metastasis focus on laryngeal carcinoma |
| topic | epithelial to mesenchymal transition (EMT) laryngeal carcinoma metastasis |
| url | https://www.mdpi.com/2227-9059/10/9/2148 |
| work_keys_str_mv | AT anastasiosgoulioumis epithelialtomesenchymaltransitioninmetastasisfocusonlaryngealcarcinoma AT kostisgyftopoulos epithelialtomesenchymaltransitioninmetastasisfocusonlaryngealcarcinoma |