Systematic analyses of the factors influencing sperm quality in patients with SARS-CoV-2 infection
Abstract To figure out how does SARS-CoV-2 affect sperm parameters and what influencing factors affect the recovery of sperm quality after infection? We conducted a prospective cohort study and initially included 122 men with SARS-CoV-2 infection. The longest time to track semen quality after infect...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-04-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-58797-y |
| _version_ | 1797219851279794176 |
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| author | Guohui Zhang Weiwei Zhi Fei Ye Dongsheng Xiong Yanan Zhang Fulin Liu Yuhong Zhao Xinrong Du Yang Wu Mingxia Hou Jiu Liu Jiajing Wei Yangzhong Silang Wenming Xu Jiuzhi Zeng Shiqi Chen Weixin Liu |
| author_facet | Guohui Zhang Weiwei Zhi Fei Ye Dongsheng Xiong Yanan Zhang Fulin Liu Yuhong Zhao Xinrong Du Yang Wu Mingxia Hou Jiu Liu Jiajing Wei Yangzhong Silang Wenming Xu Jiuzhi Zeng Shiqi Chen Weixin Liu |
| author_sort | Guohui Zhang |
| collection | DOAJ |
| description | Abstract To figure out how does SARS-CoV-2 affect sperm parameters and what influencing factors affect the recovery of sperm quality after infection? We conducted a prospective cohort study and initially included 122 men with SARS-CoV-2 infection. The longest time to track semen quality after infection is 112 days and 58 eligible patients were included in our study eventually. We subsequently exploited a linear mixed-effects model to statistically analyze their semen parameters at different time points before and after SARS-CoV-2 infection. Semen parameters were significantly reduced after SARS-CoV-2 infection, including total sperm count (211 [147; 347] to 167 [65.0; 258], P < 0.001), sperm concentration (69.0 [38.8; 97.0] to 51.0 [25.5; 71.5], P < 0.001), total sperm motility (57.5 [52.3; 65.0] to 51.0 [38.5; 56.8], P < 0.001), progressive motility (50.0 [46.2; 58.0] to 45.0 [31.5; 52.8], P < 0.001). The parameters displayed the greatest diminution within 30 days after SARS-CoV-2 infection, gradually recovered thereafter, and exhibited no significant difference after 90 days compared with prior to COVID-19 infection. In addition, the patients in the group with a low-grade fever showed a declining tendency in semen parameters, but not to a significant degree, whereas those men with a moderate or high fever produced a significant drop in the same parameters. Semen parameters were significantly reduced after SARS-CoV-2 infection, and fever severity during SARS-CoV-2 infection may constitute the main influencing factor in reducing semen parameters in patients after recovery, but the effect is reversible and the semen parameters gradually return to normal with the realization of a new spermatogenic cycle. |
| first_indexed | 2024-04-24T12:40:13Z |
| format | Article |
| id | doaj.art-2d7d2ea50d8e4f519fb4cdc4d2085fe1 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T12:40:13Z |
| publishDate | 2024-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-2d7d2ea50d8e4f519fb4cdc4d2085fe12024-04-07T11:17:26ZengNature PortfolioScientific Reports2045-23222024-04-0114111710.1038/s41598-024-58797-ySystematic analyses of the factors influencing sperm quality in patients with SARS-CoV-2 infectionGuohui Zhang0Weiwei Zhi1Fei Ye2Dongsheng Xiong3Yanan Zhang4Fulin Liu5Yuhong Zhao6Xinrong Du7Yang Wu8Mingxia Hou9Jiu Liu10Jiajing Wei11Yangzhong Silang12Wenming Xu13Jiuzhi Zeng14Shiqi Chen15Weixin Liu16Key Laboratory of Reproductive Medicine, Sichuan Provincial Maternity and Child Health Care HospitalKey Laboratory of Reproductive Medicine, Sichuan Provincial Maternity and Child Health Care HospitalKey Laboratory of Reproductive Medicine, Sichuan Provincial Maternity and Child Health Care HospitalKey Laboratory of Reproductive Medicine, Sichuan Provincial Maternity and Child Health Care HospitalKey Laboratory of Reproductive Medicine, Sichuan Provincial Maternity and Child Health Care HospitalSichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, University of Electronic Science and TechnologySchool of Laboratory Medicine, Chengdu Medical CollegeChengdu University of Traditional Chinese MedicineKey Laboratory of Reproductive Medicine, Sichuan Provincial Maternity and Child Health Care HospitalKey Laboratory of Reproductive Medicine, Sichuan Provincial Maternity and Child Health Care HospitalKey Laboratory of Reproductive Medicine, Sichuan Provincial Maternity and Child Health Care HospitalKey Laboratory of Reproductive Medicine, Sichuan Provincial Maternity and Child Health Care HospitalKey Laboratory of Reproductive Medicine, Sichuan Provincial Maternity and Child Health Care HospitalDepartment of Obstetrics and Gynecology, Joint Laboratory of Reproductive Medicine (SCU-CUHK), Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan UniversityKey Laboratory of Reproductive Medicine, Sichuan Provincial Maternity and Child Health Care HospitalKey Laboratory of Reproductive Medicine, Sichuan Provincial Maternity and Child Health Care HospitalKey Laboratory of Reproductive Medicine, Sichuan Provincial Maternity and Child Health Care HospitalAbstract To figure out how does SARS-CoV-2 affect sperm parameters and what influencing factors affect the recovery of sperm quality after infection? We conducted a prospective cohort study and initially included 122 men with SARS-CoV-2 infection. The longest time to track semen quality after infection is 112 days and 58 eligible patients were included in our study eventually. We subsequently exploited a linear mixed-effects model to statistically analyze their semen parameters at different time points before and after SARS-CoV-2 infection. Semen parameters were significantly reduced after SARS-CoV-2 infection, including total sperm count (211 [147; 347] to 167 [65.0; 258], P < 0.001), sperm concentration (69.0 [38.8; 97.0] to 51.0 [25.5; 71.5], P < 0.001), total sperm motility (57.5 [52.3; 65.0] to 51.0 [38.5; 56.8], P < 0.001), progressive motility (50.0 [46.2; 58.0] to 45.0 [31.5; 52.8], P < 0.001). The parameters displayed the greatest diminution within 30 days after SARS-CoV-2 infection, gradually recovered thereafter, and exhibited no significant difference after 90 days compared with prior to COVID-19 infection. In addition, the patients in the group with a low-grade fever showed a declining tendency in semen parameters, but not to a significant degree, whereas those men with a moderate or high fever produced a significant drop in the same parameters. Semen parameters were significantly reduced after SARS-CoV-2 infection, and fever severity during SARS-CoV-2 infection may constitute the main influencing factor in reducing semen parameters in patients after recovery, but the effect is reversible and the semen parameters gradually return to normal with the realization of a new spermatogenic cycle.https://doi.org/10.1038/s41598-024-58797-ySemen parametersSARS-CoV-2FeverLinear mixed-effects model |
| spellingShingle | Guohui Zhang Weiwei Zhi Fei Ye Dongsheng Xiong Yanan Zhang Fulin Liu Yuhong Zhao Xinrong Du Yang Wu Mingxia Hou Jiu Liu Jiajing Wei Yangzhong Silang Wenming Xu Jiuzhi Zeng Shiqi Chen Weixin Liu Systematic analyses of the factors influencing sperm quality in patients with SARS-CoV-2 infection Scientific Reports Semen parameters SARS-CoV-2 Fever Linear mixed-effects model |
| title | Systematic analyses of the factors influencing sperm quality in patients with SARS-CoV-2 infection |
| title_full | Systematic analyses of the factors influencing sperm quality in patients with SARS-CoV-2 infection |
| title_fullStr | Systematic analyses of the factors influencing sperm quality in patients with SARS-CoV-2 infection |
| title_full_unstemmed | Systematic analyses of the factors influencing sperm quality in patients with SARS-CoV-2 infection |
| title_short | Systematic analyses of the factors influencing sperm quality in patients with SARS-CoV-2 infection |
| title_sort | systematic analyses of the factors influencing sperm quality in patients with sars cov 2 infection |
| topic | Semen parameters SARS-CoV-2 Fever Linear mixed-effects model |
| url | https://doi.org/10.1038/s41598-024-58797-y |
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