Caffeic Acid Enhances the Anti-Leukemic Effect of Imatinib on Chronic Myeloid Leukemia Cells and Triggers Apoptosis in Cells Sensitive and Resistant to Imatinib

Caffeic Acid Enhances the Anti-Leukemic Effect of Imatinib on Chronic Myeloid Leukemia Cells and Triggers Apoptosis in Cells Sensitive and Resistant to Imatinib

Among the phenolic acids tested on the K562 cell line, a model of chronic myeloid leukemia (CML), caffeic acid (CA) was biologically active on sensitive and imatinib (IM)-resistant cells at micro-molar concentration, either in terms of reduction of cell proliferation or triggering of apoptosis. The...

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Bibliographic Details
Main Authors: Giordana Feriotto, Federico Tagliati, Riccardo Giriolo, Fabio Casciano, Claudio Tabolacci, Simone Beninati, Mahmud Tareq Hassan Khan, Carlo Mischiati
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
caffeic acid
apoptosis
chronic myeloid leukemia
imatinib
resistance
Online Access:https://www.mdpi.com/1422-0067/22/4/1644

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