Characteristics of Multiple Acute Concomitant Cerebral Infarcts Involving Different Arterial Territories
(1) Background: Multiple acute concomitant cerebral infarcts (MACCI) are relatively uncommon. Data regarding the characteristics and outcomes of patients with MACCI are lacking. We, therefore, aimed to characterize the clinical features of MACCI. (2) Methods: Patients with MACCI were identified from...
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| Format: | Article |
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MDPI AG
2023-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/12/3973 |
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| author | Naaem Simaan Leen Fahoum Andrei Filioglo Shorooq Aladdin Karine Wiegler Beiruti Asaf Honig Ronen Leker |
| author_facet | Naaem Simaan Leen Fahoum Andrei Filioglo Shorooq Aladdin Karine Wiegler Beiruti Asaf Honig Ronen Leker |
| author_sort | Naaem Simaan |
| collection | DOAJ |
| description | (1) Background: Multiple acute concomitant cerebral infarcts (MACCI) are relatively uncommon. Data regarding the characteristics and outcomes of patients with MACCI are lacking. We, therefore, aimed to characterize the clinical features of MACCI. (2) Methods: Patients with MACCI were identified from a prospective registry of stroke patients admitted to a tertiary teaching center. Patients with an acute single embolic stroke (ASES) involving only one vascular bed served as controls. (3) Results: MACCI was diagnosed in 103 patients who were compared to 150 patients with ASES. MACCI patients were significantly older (<i>p</i> = 0.010), more often had a history of diabetes (<i>p</i> = 0.011) and had lower rates of ischemic heart disease (<i>p</i> = 0.022). On admission, MACCI patients had significantly higher rates of focal signs (<i>p</i> < 0.001), an altered mental state (<i>p</i> < 0.001) and seizures (<i>p</i> = 0.036). The favorable functional outcome was significantly less common in patients with MACCI (<i>p</i> = 0.006). In the multivariable analysis, MACCI was associated with lower chances of achieving favorable outcomes (odds ratio: 0.190, 95% CI: 0.070–0.502). (4) Conclusions: There are important differences in clinical presentation, comorbidities and outcomes between MACCI and ASES. MACCI is less often associated with favorable outcomes and could represent a more severe form of a stroke compared with a single embolic stroke. |
| first_indexed | 2024-03-11T02:18:08Z |
| format | Article |
| id | doaj.art-2d827d6bf7344e4dad791d049866775a |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T02:18:08Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-2d827d6bf7344e4dad791d049866775a2023-11-18T10:59:12ZengMDPI AGJournal of Clinical Medicine2077-03832023-06-011212397310.3390/jcm12123973Characteristics of Multiple Acute Concomitant Cerebral Infarcts Involving Different Arterial TerritoriesNaaem Simaan0Leen Fahoum1Andrei Filioglo2Shorooq Aladdin3Karine Wiegler Beiruti4Asaf Honig5Ronen Leker6Department of Neurology, Ziv Medical Center, Safed 13100, IsraelDepartment of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, IsraelDepartment of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, IsraelDepartment of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, IsraelResearch Wing, Ziv Medical Center, Safed 13100, IsraelDepartment of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, IsraelDepartment of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel(1) Background: Multiple acute concomitant cerebral infarcts (MACCI) are relatively uncommon. Data regarding the characteristics and outcomes of patients with MACCI are lacking. We, therefore, aimed to characterize the clinical features of MACCI. (2) Methods: Patients with MACCI were identified from a prospective registry of stroke patients admitted to a tertiary teaching center. Patients with an acute single embolic stroke (ASES) involving only one vascular bed served as controls. (3) Results: MACCI was diagnosed in 103 patients who were compared to 150 patients with ASES. MACCI patients were significantly older (<i>p</i> = 0.010), more often had a history of diabetes (<i>p</i> = 0.011) and had lower rates of ischemic heart disease (<i>p</i> = 0.022). On admission, MACCI patients had significantly higher rates of focal signs (<i>p</i> < 0.001), an altered mental state (<i>p</i> < 0.001) and seizures (<i>p</i> = 0.036). The favorable functional outcome was significantly less common in patients with MACCI (<i>p</i> = 0.006). In the multivariable analysis, MACCI was associated with lower chances of achieving favorable outcomes (odds ratio: 0.190, 95% CI: 0.070–0.502). (4) Conclusions: There are important differences in clinical presentation, comorbidities and outcomes between MACCI and ASES. MACCI is less often associated with favorable outcomes and could represent a more severe form of a stroke compared with a single embolic stroke.https://www.mdpi.com/2077-0383/12/12/3973cerebral infarctsacute single embolic strokeshower of emboliarterial territoriesencephalopathy |
| spellingShingle | Naaem Simaan Leen Fahoum Andrei Filioglo Shorooq Aladdin Karine Wiegler Beiruti Asaf Honig Ronen Leker Characteristics of Multiple Acute Concomitant Cerebral Infarcts Involving Different Arterial Territories Journal of Clinical Medicine cerebral infarcts acute single embolic stroke shower of emboli arterial territories encephalopathy |
| title | Characteristics of Multiple Acute Concomitant Cerebral Infarcts Involving Different Arterial Territories |
| title_full | Characteristics of Multiple Acute Concomitant Cerebral Infarcts Involving Different Arterial Territories |
| title_fullStr | Characteristics of Multiple Acute Concomitant Cerebral Infarcts Involving Different Arterial Territories |
| title_full_unstemmed | Characteristics of Multiple Acute Concomitant Cerebral Infarcts Involving Different Arterial Territories |
| title_short | Characteristics of Multiple Acute Concomitant Cerebral Infarcts Involving Different Arterial Territories |
| title_sort | characteristics of multiple acute concomitant cerebral infarcts involving different arterial territories |
| topic | cerebral infarcts acute single embolic stroke shower of emboli arterial territories encephalopathy |
| url | https://www.mdpi.com/2077-0383/12/12/3973 |
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