Arousal-Mediated Sleep Disturbance Persists During Cocaine Abstinence in Male Mice
Acute cocaine disturbs sleep on a dose-dependent basis; however, the consequences of chronic cocaine remain unclear. While the arousal promotion following cocaine has been well-established, effects of cocaine on sleep after termination of chronic cocaine exposure appear variable in human subjects wi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.868049/full |
| _version_ | 1811343680322142208 |
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| author | Theresa E. Bjorness Theresa E. Bjorness Robert W. Greene Robert W. Greene Robert W. Greene |
| author_facet | Theresa E. Bjorness Theresa E. Bjorness Robert W. Greene Robert W. Greene Robert W. Greene |
| author_sort | Theresa E. Bjorness |
| collection | DOAJ |
| description | Acute cocaine disturbs sleep on a dose-dependent basis; however, the consequences of chronic cocaine remain unclear. While the arousal promotion following cocaine has been well-established, effects of cocaine on sleep after termination of chronic cocaine exposure appear variable in human subjects with few studies in non-human subjects. Here, a within-subjects design (outcomes normalized to baseline, undisturbed behavior) and between-subjects design (repeated experimenter-administered cocaine vs. experimenter-administered saline) was used to investigate sleep homeostasis and sleep/waking under repeated cocaine/saline exposure and prolonged forced abstinence conditions in mice. Overall, during the forced abstinence period increases in arousal, as determined by sleep latency and gamma energy, persisted for 2 weeks. However, the sleep response to externally enforced sleep deprivation was unchanged suggesting that sleep disruptions during the forced abstinence period were driven by enhancement of arousal in the absence of changes in sleep homeostatic responses. |
| first_indexed | 2024-04-13T19:34:14Z |
| format | Article |
| id | doaj.art-2d86c45068874857b07bee7a39748e14 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-13T19:34:14Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-2d86c45068874857b07bee7a39748e142022-12-22T02:33:06ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-06-011610.3389/fnins.2022.868049868049Arousal-Mediated Sleep Disturbance Persists During Cocaine Abstinence in Male MiceTheresa E. Bjorness0Theresa E. Bjorness1Robert W. Greene2Robert W. Greene3Robert W. Greene4Research Service, Veterans Affairs (VA) North Texas Health Care System, Dallas, TX, United StatesDepartment of Psychiatry, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern, Dallas, TX, United StatesDepartment of Psychiatry, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern, Dallas, TX, United StatesDepartment of Neuroscience, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, United StatesInternational Institute for Integrative Sleep Medicine, University of Tsukuba, Tsukuba, JapanAcute cocaine disturbs sleep on a dose-dependent basis; however, the consequences of chronic cocaine remain unclear. While the arousal promotion following cocaine has been well-established, effects of cocaine on sleep after termination of chronic cocaine exposure appear variable in human subjects with few studies in non-human subjects. Here, a within-subjects design (outcomes normalized to baseline, undisturbed behavior) and between-subjects design (repeated experimenter-administered cocaine vs. experimenter-administered saline) was used to investigate sleep homeostasis and sleep/waking under repeated cocaine/saline exposure and prolonged forced abstinence conditions in mice. Overall, during the forced abstinence period increases in arousal, as determined by sleep latency and gamma energy, persisted for 2 weeks. However, the sleep response to externally enforced sleep deprivation was unchanged suggesting that sleep disruptions during the forced abstinence period were driven by enhancement of arousal in the absence of changes in sleep homeostatic responses.https://www.frontiersin.org/articles/10.3389/fnins.2022.868049/fullsleepcocaineslow wave activityarousalmouse |
| spellingShingle | Theresa E. Bjorness Theresa E. Bjorness Robert W. Greene Robert W. Greene Robert W. Greene Arousal-Mediated Sleep Disturbance Persists During Cocaine Abstinence in Male Mice Frontiers in Neuroscience sleep cocaine slow wave activity arousal mouse |
| title | Arousal-Mediated Sleep Disturbance Persists During Cocaine Abstinence in Male Mice |
| title_full | Arousal-Mediated Sleep Disturbance Persists During Cocaine Abstinence in Male Mice |
| title_fullStr | Arousal-Mediated Sleep Disturbance Persists During Cocaine Abstinence in Male Mice |
| title_full_unstemmed | Arousal-Mediated Sleep Disturbance Persists During Cocaine Abstinence in Male Mice |
| title_short | Arousal-Mediated Sleep Disturbance Persists During Cocaine Abstinence in Male Mice |
| title_sort | arousal mediated sleep disturbance persists during cocaine abstinence in male mice |
| topic | sleep cocaine slow wave activity arousal mouse |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.868049/full |
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