Structural basis for the toxicity of Legionella pneumophila effector SidH

Structural basis for the toxicity of Legionella pneumophila effector SidH

Abstract Legionella pneumophila (LP) secretes more than 300 effectors into the host cytosol to facilitate intracellular replication. One of these effectors, SidH, 253 kDa in size with no sequence similarity to proteins of known function is toxic when overexpressed in host cells. SidH is regulated by...

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Bibliographic Details
Main Authors: Rahul Sharma, Michael Adams, Simonne Griffith-Jones, Tobias Sahr, Laura Gomez-Valero, Felix Weis, Michael Hons, Sarah Gharbi, Rayene Berkane, Alexandra Stolz, Carmen Buchrieser, Sagar Bhogaraju
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42683-8

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