Flavopiridol Protects Bone Tissue by Attenuating RANKL Induced Osteoclast Formation

Flavopiridol Protects Bone Tissue by Attenuating RANKL Induced Osteoclast Formation

Bone resorption and homeostasis is carried out by osteoclasts, whose differentiation and activity are regulated by the RANK/RANKL axis. Our previous studies using a mouse model of joint injury show that joint trauma induces local inflammation followed by bone remodeling. The transcription factor cyc...

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Bibliographic Details
Main Authors: Zi’ang Hu, Yilei Chen, Lijiang Song, Jasper H. N. Yik, Dominik R. Haudenschild, Shunwu Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Pharmacology
Subjects:
flavopiridol
CDK9
osteoclast
bone resorption
NF-κB
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00174/full

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