Modulation of BAG-1 Expression Alters the Sensitivity of Breast Cancer Cells to Tamoxifen

Modulation of BAG-1 Expression Alters the Sensitivity of Breast Cancer Cells to Tamoxifen

Background: BAG-1 (bcl-2 associated athanogene) is a multifunctional protein that protects cells from a wide range of apoptotic stimuli including radiation, hypoxia and chemotherapeutic agents. Overexpression of cytoplasmic BAG-1 has been associated with the increased survival and decreased response...

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Bibliographic Details
Main Authors: Hong Liu, Su Lu, Lin Gu, Yongchang Gao, Tong Wang, Jing Zhao, Jianyu Rao, Jun Chen, Xishan Hao, Shou-Ching Tang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-02-01
Series:Cellular Physiology and Biochemistry
Subjects:
Apoptosis
Hormonal therapy
TAM resistance
BAG-1
Breast cancer
Online Access:http://www.karger.com/Article/FullText/356676

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