Regulatory T cell frequency in patients with melanoma with different disease stage and course, and modulating effects of high-dose interferon-α 2b treatment

Regulatory T cell frequency in patients with melanoma with different disease stage and course, and modulating effects of high-dose interferon-α 2b treatment

<p>Abstract</p> <p>Background</p> <p>High-dose interferon-alpha 2b (IFN-α 2b) is the only approved systemic therapy in the United States for the adjuvant treatment of melanoma. The study objective was to explore the immunomodulatory mechanism of action for IFN-α 2b by m...

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Main Authors: Ascierto Paolo A, Napolitano Maria, Celentano Egidio, Simeone Ester, Gentilcore Giusy, Daponte Antonio, Capone Mariaelena, Caracò Corrado, Calemma Rosa, Beneduce Gerardo, Cerrone Margherita, De Rosa Vincenzo, Palmieri Giuseppe, Castello Giuseppe, Kirkwood John M, Marincola Francesco M, Mozzillo Nicola
Format: Article
Language:English
Published: BMC 2010-08-01
Series:Journal of Translational Medicine
Online Access:http://www.translational-medicine.com/content/8/1/76

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