Comparison of Carotid‐Femoral and Brachial‐Ankle Pulse‐Wave Velocity in Association With Target Organ Damage in the Community‐Dwelling Elderly Chinese: The Northern Shanghai Study
BackgroundCarotid‐femoral pulse‐wave velocity (cf‐PWV) and brachial‐ankle PWV (ba‐PWV) are the 2 most frequently applied PWV measurements. However, little is known about the comparison of hypertensive target organ damage (TOD) with cf‐PWV and ba‐PWV. Methods and ResultsA total of 1599 community‐dwel...
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| Format: | Article |
| Language: | English |
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Wiley
2017-02-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.116.004168 |
| _version_ | 1818328061041442816 |
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| author | Yuyan Lu Mengyun Zhu Bin Bai Chen Chi Shikai Yu Jiadela Teliewubai Henry Xu Kai Wang Jing Xiong Yiwu Zhou Hongwei Ji Ximin Fan Xuejing Yu Jue Li Jacques Blacher Yi Zhang Yawei Xu |
| author_facet | Yuyan Lu Mengyun Zhu Bin Bai Chen Chi Shikai Yu Jiadela Teliewubai Henry Xu Kai Wang Jing Xiong Yiwu Zhou Hongwei Ji Ximin Fan Xuejing Yu Jue Li Jacques Blacher Yi Zhang Yawei Xu |
| author_sort | Yuyan Lu |
| collection | DOAJ |
| description | BackgroundCarotid‐femoral pulse‐wave velocity (cf‐PWV) and brachial‐ankle PWV (ba‐PWV) are the 2 most frequently applied PWV measurements. However, little is known about the comparison of hypertensive target organ damage (TOD) with cf‐PWV and ba‐PWV. Methods and ResultsA total of 1599 community‐dwelling elderly subjects (age >65 years) in northern Shanghai were recruited from June 2014 to August 2015. Both cf‐PWV and ba‐PWV were measured using SphygmoCor and VP1000 systems, respectively. Within the framework of comprehensive cardiovascular examinations, risk factors were assessed, and asymptomatic TOD, including left ventricular mass index, peak transmitral pulsed Doppler velocity/early diastolic tissue Doppler velocity (E/Ea), carotid intima‐media thickness, arterial plaque, creatinine clearance rate, and urinary albumin‐creatinine ratio were all evaluated. Both PWVs were significantly associated with male sex, age, waist/hip circumference, fasting plasma glucose, and systolic blood pressure, and ba‐PWV was also significantly related to body mass index. Both PWVs were significantly correlated with most TOD. When cf‐PWV and ba‐PWV were both or separately put into the stepwise linear regression model together with cardiovascular risk factors and treatment, only cf‐PWV, but not ba‐PWV, was significantly associated with carotid intima‐media thickness and creatinine clearance rate (P<0.05). When cf‐PWV and ba‐PWV were both or separately put into the same full‐mode model after adjustment for confounders, only cf‐PWV, but not ba‐PWV, showed significant association with carotid intima‐media thickness and creatinine clearance rate (P<0.05). Similar results were observed in logistic regression analysis. ConclusionsTaken together, in the community‐dwelling elderly Chinese, cf‐PWV seems to be more closely associated with hypertensive TOD, especially vascular and renal TOD, as compared with ba‐PWV. Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT02368938. |
| first_indexed | 2024-12-13T12:26:10Z |
| format | Article |
| id | doaj.art-2d95d40e9c784bbe887ed5f081a4d639 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-13T12:26:10Z |
| publishDate | 2017-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-2d95d40e9c784bbe887ed5f081a4d6392022-12-21T23:46:18ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802017-02-016210.1161/JAHA.116.004168Comparison of Carotid‐Femoral and Brachial‐Ankle Pulse‐Wave Velocity in Association With Target Organ Damage in the Community‐Dwelling Elderly Chinese: The Northern Shanghai StudyYuyan Lu0Mengyun Zhu1Bin Bai2Chen Chi3Shikai Yu4Jiadela Teliewubai5Henry Xu6Kai Wang7Jing Xiong8Yiwu Zhou9Hongwei Ji10Ximin Fan11Xuejing Yu12Jue Li13Jacques Blacher14Yi Zhang15Yawei Xu16Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Prevention, Tongji University School of Medicine, Shanghai, ChinaDiagnosis and Therapeutic Center, Hôtel‐Dieu, AP‐HP, Paris Descartes University, Paris, FranceDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, ChinaBackgroundCarotid‐femoral pulse‐wave velocity (cf‐PWV) and brachial‐ankle PWV (ba‐PWV) are the 2 most frequently applied PWV measurements. However, little is known about the comparison of hypertensive target organ damage (TOD) with cf‐PWV and ba‐PWV. Methods and ResultsA total of 1599 community‐dwelling elderly subjects (age >65 years) in northern Shanghai were recruited from June 2014 to August 2015. Both cf‐PWV and ba‐PWV were measured using SphygmoCor and VP1000 systems, respectively. Within the framework of comprehensive cardiovascular examinations, risk factors were assessed, and asymptomatic TOD, including left ventricular mass index, peak transmitral pulsed Doppler velocity/early diastolic tissue Doppler velocity (E/Ea), carotid intima‐media thickness, arterial plaque, creatinine clearance rate, and urinary albumin‐creatinine ratio were all evaluated. Both PWVs were significantly associated with male sex, age, waist/hip circumference, fasting plasma glucose, and systolic blood pressure, and ba‐PWV was also significantly related to body mass index. Both PWVs were significantly correlated with most TOD. When cf‐PWV and ba‐PWV were both or separately put into the stepwise linear regression model together with cardiovascular risk factors and treatment, only cf‐PWV, but not ba‐PWV, was significantly associated with carotid intima‐media thickness and creatinine clearance rate (P<0.05). When cf‐PWV and ba‐PWV were both or separately put into the same full‐mode model after adjustment for confounders, only cf‐PWV, but not ba‐PWV, showed significant association with carotid intima‐media thickness and creatinine clearance rate (P<0.05). Similar results were observed in logistic regression analysis. ConclusionsTaken together, in the community‐dwelling elderly Chinese, cf‐PWV seems to be more closely associated with hypertensive TOD, especially vascular and renal TOD, as compared with ba‐PWV. Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT02368938.https://www.ahajournals.org/doi/10.1161/JAHA.116.004168brachial‐ankle pulse‐wave velocitycardiovascular disease risk factorscarotid‐femoral pulse‐wave velocitytarget organ damage |
| spellingShingle | Yuyan Lu Mengyun Zhu Bin Bai Chen Chi Shikai Yu Jiadela Teliewubai Henry Xu Kai Wang Jing Xiong Yiwu Zhou Hongwei Ji Ximin Fan Xuejing Yu Jue Li Jacques Blacher Yi Zhang Yawei Xu Comparison of Carotid‐Femoral and Brachial‐Ankle Pulse‐Wave Velocity in Association With Target Organ Damage in the Community‐Dwelling Elderly Chinese: The Northern Shanghai Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease brachial‐ankle pulse‐wave velocity cardiovascular disease risk factors carotid‐femoral pulse‐wave velocity target organ damage |
| title | Comparison of Carotid‐Femoral and Brachial‐Ankle Pulse‐Wave Velocity in Association With Target Organ Damage in the Community‐Dwelling Elderly Chinese: The Northern Shanghai Study |
| title_full | Comparison of Carotid‐Femoral and Brachial‐Ankle Pulse‐Wave Velocity in Association With Target Organ Damage in the Community‐Dwelling Elderly Chinese: The Northern Shanghai Study |
| title_fullStr | Comparison of Carotid‐Femoral and Brachial‐Ankle Pulse‐Wave Velocity in Association With Target Organ Damage in the Community‐Dwelling Elderly Chinese: The Northern Shanghai Study |
| title_full_unstemmed | Comparison of Carotid‐Femoral and Brachial‐Ankle Pulse‐Wave Velocity in Association With Target Organ Damage in the Community‐Dwelling Elderly Chinese: The Northern Shanghai Study |
| title_short | Comparison of Carotid‐Femoral and Brachial‐Ankle Pulse‐Wave Velocity in Association With Target Organ Damage in the Community‐Dwelling Elderly Chinese: The Northern Shanghai Study |
| title_sort | comparison of carotid femoral and brachial ankle pulse wave velocity in association with target organ damage in the community dwelling elderly chinese the northern shanghai study |
| topic | brachial‐ankle pulse‐wave velocity cardiovascular disease risk factors carotid‐femoral pulse‐wave velocity target organ damage |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.116.004168 |
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