Neuroglobin – recent developments
Neuroglobin (Ngb), a monomeric hexacoordinated heme protein of 17 kDa, was identified in 2000 in the nervous system. Accumulative evidence has proved that Ngb is an endogenous neuroprotective molecule against ischemic/hypoxic insults and oxidative stresses, and in most ischemic conditions, Ngb is up...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2014-06-01
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| Series: | Biomolecular Concepts |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/bmc-2014-0011 |
| Summary: | Neuroglobin (Ngb), a monomeric hexacoordinated heme protein of 17 kDa, was identified in 2000 in the nervous system. Accumulative evidence has proved that Ngb is an endogenous neuroprotective molecule against ischemic/hypoxic insults and oxidative stresses, and in most ischemic conditions, Ngb is up-regulated. The underlying mechanisms, however, are not fully clarified. Here we review the recent experimental findings, mainly focusing on the mechanisms of Ngb’s protection and induction during ischemic/hypoxic conditions, the roles of Ngb in astrocytes and tumors, as well as Ngb’s function in neurite outgrowth. |
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| ISSN: | 1868-5021 1868-503X |