Neuroglobin – recent developments
Neuroglobin (Ngb), a monomeric hexacoordinated heme protein of 17 kDa, was identified in 2000 in the nervous system. Accumulative evidence has proved that Ngb is an endogenous neuroprotective molecule against ischemic/hypoxic insults and oxidative stresses, and in most ischemic conditions, Ngb is up...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2014-06-01
|
| Series: | Biomolecular Concepts |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/bmc-2014-0011 |
| _version_ | 1819101939047071744 |
|---|---|
| author | Qiu Xin Yao Chen Xiao Qian |
| author_facet | Qiu Xin Yao Chen Xiao Qian |
| author_sort | Qiu Xin Yao |
| collection | DOAJ |
| description | Neuroglobin (Ngb), a monomeric hexacoordinated heme protein of 17 kDa, was identified in 2000 in the nervous system. Accumulative evidence has proved that Ngb is an endogenous neuroprotective molecule against ischemic/hypoxic insults and oxidative stresses, and in most ischemic conditions, Ngb is up-regulated. The underlying mechanisms, however, are not fully clarified. Here we review the recent experimental findings, mainly focusing on the mechanisms of Ngb’s protection and induction during ischemic/hypoxic conditions, the roles of Ngb in astrocytes and tumors, as well as Ngb’s function in neurite outgrowth. |
| first_indexed | 2024-12-22T01:26:38Z |
| format | Article |
| id | doaj.art-2d95d8c4b5f8410496718c8032835777 |
| institution | Directory Open Access Journal |
| issn | 1868-5021 1868-503X |
| language | English |
| last_indexed | 2024-12-22T01:26:38Z |
| publishDate | 2014-06-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Biomolecular Concepts |
| spelling | doaj.art-2d95d8c4b5f8410496718c80328357772022-12-21T18:43:35ZengDe GruyterBiomolecular Concepts1868-50211868-503X2014-06-015319520810.1515/bmc-2014-0011Neuroglobin – recent developmentsQiu Xin Yao0Chen Xiao Qian1Department of Pathophysiology, School of Basic Medicine; Key Laboratory of Neurological Diseases, Ministry of Education; Hubei Provincial Key Laboratory of Neurological Diseases; Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Pathophysiology, School of Basic Medicine; Key Laboratory of Neurological Diseases, Ministry of Education; Hubei Provincial Key Laboratory of Neurological Diseases; Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaNeuroglobin (Ngb), a monomeric hexacoordinated heme protein of 17 kDa, was identified in 2000 in the nervous system. Accumulative evidence has proved that Ngb is an endogenous neuroprotective molecule against ischemic/hypoxic insults and oxidative stresses, and in most ischemic conditions, Ngb is up-regulated. The underlying mechanisms, however, are not fully clarified. Here we review the recent experimental findings, mainly focusing on the mechanisms of Ngb’s protection and induction during ischemic/hypoxic conditions, the roles of Ngb in astrocytes and tumors, as well as Ngb’s function in neurite outgrowth.https://doi.org/10.1515/bmc-2014-0011astrocytecancerhypoxia-inducible factor-1αneuronneuroprotection |
| spellingShingle | Qiu Xin Yao Chen Xiao Qian Neuroglobin – recent developments Biomolecular Concepts astrocyte cancer hypoxia-inducible factor-1α neuron neuroprotection |
| title | Neuroglobin – recent developments |
| title_full | Neuroglobin – recent developments |
| title_fullStr | Neuroglobin – recent developments |
| title_full_unstemmed | Neuroglobin – recent developments |
| title_short | Neuroglobin – recent developments |
| title_sort | neuroglobin recent developments |
| topic | astrocyte cancer hypoxia-inducible factor-1α neuron neuroprotection |
| url | https://doi.org/10.1515/bmc-2014-0011 |
| work_keys_str_mv | AT qiuxinyao neuroglobinrecentdevelopments AT chenxiaoqian neuroglobinrecentdevelopments |