Synthetic Approaches to Diospongins: A Two Decade Journey
Tetrahydropyran units having multiple stereogenic centers serve as excellent building blocks for various active pharmaceutical ingredients (APIs). In particular, the presence of the unique molecular architecture of the trisubstituted tetrahydropyran (THP) unit in diospongins enhances their biologica...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Georg Thieme Verlag KG
2022-07-01
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| Series: | SynOpen |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1720032 |
| _version_ | 1818473792876314624 |
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| author | Krishnaji Tadiparthi Sourav Chatterjee |
| author_facet | Krishnaji Tadiparthi Sourav Chatterjee |
| author_sort | Krishnaji Tadiparthi |
| collection | DOAJ |
| description | Tetrahydropyran units having multiple stereogenic centers serve as excellent building blocks for various active pharmaceutical ingredients (APIs). In particular, the presence of the unique molecular architecture of the trisubstituted tetrahydropyran (THP) unit in diospongins enhances their biological activity due to multiple stereogenic centers and has attracted attention from the synthetic community over the last two decades. In this review, we discuss synthetic approaches to chiral and racemic forms of diospongins during the period 2006–2020 in chronological order. |
| first_indexed | 2024-04-14T04:28:11Z |
| format | Article |
| id | doaj.art-2d99913750c547fc82cb6967ec2a7d5d |
| institution | Directory Open Access Journal |
| issn | 2509-9396 |
| language | English |
| last_indexed | 2024-04-14T04:28:11Z |
| publishDate | 2022-07-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | SynOpen |
| spelling | doaj.art-2d99913750c547fc82cb6967ec2a7d5d2022-12-22T02:12:11ZengGeorg Thieme Verlag KGSynOpen2509-93962022-07-01060314115710.1055/s-0040-1720032Synthetic Approaches to Diospongins: A Two Decade JourneyKrishnaji TadiparthiSourav ChatterjeeTetrahydropyran units having multiple stereogenic centers serve as excellent building blocks for various active pharmaceutical ingredients (APIs). In particular, the presence of the unique molecular architecture of the trisubstituted tetrahydropyran (THP) unit in diospongins enhances their biological activity due to multiple stereogenic centers and has attracted attention from the synthetic community over the last two decades. In this review, we discuss synthetic approaches to chiral and racemic forms of diospongins during the period 2006–2020 in chronological order.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1720032diosponginsdiarylheptanoidstetrahydropyrancross-metathesishetero-diels–alder reactionasymmetric allylationenzyme resolutionoxa-michael additionprins cyclization |
| spellingShingle | Krishnaji Tadiparthi Sourav Chatterjee Synthetic Approaches to Diospongins: A Two Decade Journey SynOpen diospongins diarylheptanoids tetrahydropyran cross-metathesis hetero-diels–alder reaction asymmetric allylation enzyme resolution oxa-michael addition prins cyclization |
| title | Synthetic Approaches to Diospongins: A Two Decade Journey |
| title_full | Synthetic Approaches to Diospongins: A Two Decade Journey |
| title_fullStr | Synthetic Approaches to Diospongins: A Two Decade Journey |
| title_full_unstemmed | Synthetic Approaches to Diospongins: A Two Decade Journey |
| title_short | Synthetic Approaches to Diospongins: A Two Decade Journey |
| title_sort | synthetic approaches to diospongins a two decade journey |
| topic | diospongins diarylheptanoids tetrahydropyran cross-metathesis hetero-diels–alder reaction asymmetric allylation enzyme resolution oxa-michael addition prins cyclization |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1720032 |
| work_keys_str_mv | AT krishnajitadiparthi syntheticapproachestodiosponginsatwodecadejourney AT souravchatterjee syntheticapproachestodiosponginsatwodecadejourney |