Direct comparison of echocardiography speckle tracking and cardiac magnetic resonance feature tracking for quantification of right ventricular strain: a prospective intermodality study in functional mitral regurgitation
Abstract Background Functional mitral regurgitation (FMR) is a known risk factor for right ventricular dysfunction (RVDYS). RV global longitudinal strain (GLS) is an emerging index of RV function; however, the magnitude of agreement between RV GLS by echocardiography (echo) and cardiac magnetic reso...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-11-01
|
| Series: | Echo Research and Practice |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s44156-022-00011-8 |
| _version_ | 1798044420543610880 |
|---|---|
| author | Justin Johannesen Rena Fukuda David T. Zhang Katherine Tak Rachel Meier Hannah Agoglia Evelyn Horn Richard B. Devereux Jonathan W. Weinsaft Jiwon Kim |
| author_facet | Justin Johannesen Rena Fukuda David T. Zhang Katherine Tak Rachel Meier Hannah Agoglia Evelyn Horn Richard B. Devereux Jonathan W. Weinsaft Jiwon Kim |
| author_sort | Justin Johannesen |
| collection | DOAJ |
| description | Abstract Background Functional mitral regurgitation (FMR) is a known risk factor for right ventricular dysfunction (RVDYS). RV global longitudinal strain (GLS) is an emerging index of RV function; however, the magnitude of agreement between RV GLS by echocardiography (echo) and cardiac magnetic resonance (CMR) and the relative utility of each modality for both the diagnosis of RVDYS and prognostication of all-cause mortality and heart failure hospitalization remain unknown. Results 32% of patients had RVDYS (EF < 50%) on CMR, among whom there was more advanced NYHA class and lower LV and RV ejection fraction (all p < 0.05). RV GLS was impaired in patients with RVDYS whether quantified via STE or FT-CMR, with strong correlation between modalities (r = 0.81). Both STE and FT-CMR derived GLS yielded excellent detection of RVDYS (AUC 0.94 for both), paralleling similar performance for free wall strain by both modalities (FT-CMR AUC 0.94, STE AUC 0.92) with lower accuracy demonstrated by STE derived septal strain (STE AUC 0.78 and FT-CMR AUC 0.92). RV S’ and TAPSE showed lower diagnostic accuracy (RV S’ AUC 0.77 and TAPSE AUC 0.81). During median follow up of 51 months (IQR 42, 60 months), all-cause mortality or HF hospitalization occurred in 25% (n = 25). Both STE and FT-CMR derived RV GLS stratified risk for adverse prognosis (STE p = 0.007, FT-CMR p = 0.005) whereas conventional RV indices, TAPSE and RV S’, did not (TAPSE p = 0.30, S’ p = 0.69). Conclusion RV GLS is a robust marker of RVDYS irrespective of modality which provides incremental diagnostic value and improves risk stratification for event free survival beyond conventional RV indices. |
| first_indexed | 2024-04-11T23:03:32Z |
| format | Article |
| id | doaj.art-2d9b08126b024cc9b8994b03d8ee3f47 |
| institution | Directory Open Access Journal |
| issn | 2055-0464 |
| language | English |
| last_indexed | 2024-04-11T23:03:32Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Echo Research and Practice |
| spelling | doaj.art-2d9b08126b024cc9b8994b03d8ee3f472022-12-22T03:58:04ZengBMCEcho Research and Practice2055-04642022-11-019111110.1186/s44156-022-00011-8Direct comparison of echocardiography speckle tracking and cardiac magnetic resonance feature tracking for quantification of right ventricular strain: a prospective intermodality study in functional mitral regurgitationJustin Johannesen0Rena Fukuda1David T. Zhang2Katherine Tak3Rachel Meier4Hannah Agoglia5Evelyn Horn6Richard B. Devereux7Jonathan W. Weinsaft8Jiwon Kim9Division of Cardiology, Department of Medicine, Weill Cornell Medicine/New York Presbyterian HospitalDivision of Cardiology, Department of Medicine, Weill Cornell Medicine/New York Presbyterian HospitalDivision of Cardiology, Department of Medicine, Weill Cornell Medicine/New York Presbyterian HospitalDivision of Cardiology, Department of Medicine, Weill Cornell Medicine/New York Presbyterian HospitalDivision of Cardiology, Department of Medicine, Weill Cornell Medicine/New York Presbyterian HospitalDivision of Cardiology, Department of Medicine, Weill Cornell Medicine/New York Presbyterian HospitalDivision of Cardiology, Department of Medicine, Weill Cornell Medicine/New York Presbyterian HospitalDivision of Cardiology, Department of Medicine, Weill Cornell Medicine/New York Presbyterian HospitalDivision of Cardiology, Department of Medicine, Weill Cornell Medicine/New York Presbyterian HospitalDivision of Cardiology, Department of Medicine, Weill Cornell Medicine/New York Presbyterian HospitalAbstract Background Functional mitral regurgitation (FMR) is a known risk factor for right ventricular dysfunction (RVDYS). RV global longitudinal strain (GLS) is an emerging index of RV function; however, the magnitude of agreement between RV GLS by echocardiography (echo) and cardiac magnetic resonance (CMR) and the relative utility of each modality for both the diagnosis of RVDYS and prognostication of all-cause mortality and heart failure hospitalization remain unknown. Results 32% of patients had RVDYS (EF < 50%) on CMR, among whom there was more advanced NYHA class and lower LV and RV ejection fraction (all p < 0.05). RV GLS was impaired in patients with RVDYS whether quantified via STE or FT-CMR, with strong correlation between modalities (r = 0.81). Both STE and FT-CMR derived GLS yielded excellent detection of RVDYS (AUC 0.94 for both), paralleling similar performance for free wall strain by both modalities (FT-CMR AUC 0.94, STE AUC 0.92) with lower accuracy demonstrated by STE derived septal strain (STE AUC 0.78 and FT-CMR AUC 0.92). RV S’ and TAPSE showed lower diagnostic accuracy (RV S’ AUC 0.77 and TAPSE AUC 0.81). During median follow up of 51 months (IQR 42, 60 months), all-cause mortality or HF hospitalization occurred in 25% (n = 25). Both STE and FT-CMR derived RV GLS stratified risk for adverse prognosis (STE p = 0.007, FT-CMR p = 0.005) whereas conventional RV indices, TAPSE and RV S’, did not (TAPSE p = 0.30, S’ p = 0.69). Conclusion RV GLS is a robust marker of RVDYS irrespective of modality which provides incremental diagnostic value and improves risk stratification for event free survival beyond conventional RV indices.https://doi.org/10.1186/s44156-022-00011-8Right ventricular strainGlobal longitudinal strainSpeckle trackingFeature trackingCardiac magnetic resonance |
| spellingShingle | Justin Johannesen Rena Fukuda David T. Zhang Katherine Tak Rachel Meier Hannah Agoglia Evelyn Horn Richard B. Devereux Jonathan W. Weinsaft Jiwon Kim Direct comparison of echocardiography speckle tracking and cardiac magnetic resonance feature tracking for quantification of right ventricular strain: a prospective intermodality study in functional mitral regurgitation Echo Research and Practice Right ventricular strain Global longitudinal strain Speckle tracking Feature tracking Cardiac magnetic resonance |
| title | Direct comparison of echocardiography speckle tracking and cardiac magnetic resonance feature tracking for quantification of right ventricular strain: a prospective intermodality study in functional mitral regurgitation |
| title_full | Direct comparison of echocardiography speckle tracking and cardiac magnetic resonance feature tracking for quantification of right ventricular strain: a prospective intermodality study in functional mitral regurgitation |
| title_fullStr | Direct comparison of echocardiography speckle tracking and cardiac magnetic resonance feature tracking for quantification of right ventricular strain: a prospective intermodality study in functional mitral regurgitation |
| title_full_unstemmed | Direct comparison of echocardiography speckle tracking and cardiac magnetic resonance feature tracking for quantification of right ventricular strain: a prospective intermodality study in functional mitral regurgitation |
| title_short | Direct comparison of echocardiography speckle tracking and cardiac magnetic resonance feature tracking for quantification of right ventricular strain: a prospective intermodality study in functional mitral regurgitation |
| title_sort | direct comparison of echocardiography speckle tracking and cardiac magnetic resonance feature tracking for quantification of right ventricular strain a prospective intermodality study in functional mitral regurgitation |
| topic | Right ventricular strain Global longitudinal strain Speckle tracking Feature tracking Cardiac magnetic resonance |
| url | https://doi.org/10.1186/s44156-022-00011-8 |
| work_keys_str_mv | AT justinjohannesen directcomparisonofechocardiographyspeckletrackingandcardiacmagneticresonancefeaturetrackingforquantificationofrightventricularstrainaprospectiveintermodalitystudyinfunctionalmitralregurgitation AT renafukuda directcomparisonofechocardiographyspeckletrackingandcardiacmagneticresonancefeaturetrackingforquantificationofrightventricularstrainaprospectiveintermodalitystudyinfunctionalmitralregurgitation AT davidtzhang directcomparisonofechocardiographyspeckletrackingandcardiacmagneticresonancefeaturetrackingforquantificationofrightventricularstrainaprospectiveintermodalitystudyinfunctionalmitralregurgitation AT katherinetak directcomparisonofechocardiographyspeckletrackingandcardiacmagneticresonancefeaturetrackingforquantificationofrightventricularstrainaprospectiveintermodalitystudyinfunctionalmitralregurgitation AT rachelmeier directcomparisonofechocardiographyspeckletrackingandcardiacmagneticresonancefeaturetrackingforquantificationofrightventricularstrainaprospectiveintermodalitystudyinfunctionalmitralregurgitation AT hannahagoglia directcomparisonofechocardiographyspeckletrackingandcardiacmagneticresonancefeaturetrackingforquantificationofrightventricularstrainaprospectiveintermodalitystudyinfunctionalmitralregurgitation AT evelynhorn directcomparisonofechocardiographyspeckletrackingandcardiacmagneticresonancefeaturetrackingforquantificationofrightventricularstrainaprospectiveintermodalitystudyinfunctionalmitralregurgitation AT richardbdevereux directcomparisonofechocardiographyspeckletrackingandcardiacmagneticresonancefeaturetrackingforquantificationofrightventricularstrainaprospectiveintermodalitystudyinfunctionalmitralregurgitation AT jonathanwweinsaft directcomparisonofechocardiographyspeckletrackingandcardiacmagneticresonancefeaturetrackingforquantificationofrightventricularstrainaprospectiveintermodalitystudyinfunctionalmitralregurgitation AT jiwonkim directcomparisonofechocardiographyspeckletrackingandcardiacmagneticresonancefeaturetrackingforquantificationofrightventricularstrainaprospectiveintermodalitystudyinfunctionalmitralregurgitation |