Osthole, a Natural Plant Derivative Inhibits MRGPRX2 Induced Mast Cell Responses

Osthole, a Natural Plant Derivative Inhibits MRGPRX2 Induced Mast Cell Responses

Mast cells are tissue-resident innate immune cells known for their prominent role in mediating allergic reactions. MAS-related G-protein coupled receptor-X2 (MRGPRX2) is a promiscuous G-protein coupled receptor (GPCR) expressed on mast cells that is activated by several ligands that share cationic a...

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Bibliographic Details
Main Authors: Brianna N. Callahan, Ananth K. Kammala, Meesum Syed, Canchai Yang, Christopher J. Occhiuto, Rithvik Nellutla, Alena P. Chumanevich, Carole A. Oskeritzian, Rupali Das, Hariharan Subramanian
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
mast cells
pseudo-allergic reactions
osthole
MAS-related G-protein coupled receptor-X2
MrgprB2
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00703/full

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